UNASSIGNED:鼻甲手术是药物治疗难治性过敏性鼻炎(AR)的有效治疗方法。然而,鼻甲手术的长期结局尚不清楚,尚未通过荟萃分析和文献系统综述得到证实.
UNASSIGNED:通过荟萃分析研究鼻甲手术在AR中的长期结局和安全性。
未经批准:MEDLINE,Embase,Cochrane图书馆,和ClinicalTrials.gov在2021年4月进行了搜索。
未经评估:仅分析鼻甲手术的研究,随访时间超过1年,检查鼻甲手术的长期疗效,目前使用的鼻甲手术方法,并发表在同行评审的期刊上。全文审阅由2名独立审阅者进行。冲突由第三位审稿人解决。
UNASSIGNED:提取了描述性和定量数据;在随机效应模型下合成了加权平均差(WMD)。使用Q统计量和I2度量来评估异质性。这项研究是根据系统评价和荟萃分析(PRISMA)报告指南的首选报告项目进行的。
UNASSIGNED:鼻甲手术对主观鼻部症状和客观参数的长期结果。
未经评估:在检索到的3962篇引文中,包括1411名患者的18项研究。研究结果表明,鼻塞的症状评分显着降低(WMD,4.60,95%CI,3.43-5.76),鼻漏(大规模杀伤性武器,3.12;95%CI,1.97-4.28),打喷嚏(大规模杀伤性武器,2.64;95%CI,1.74-3.54),瘙痒(大规模杀伤性武器,1.75;95%CI,1.20-2.30),和鼻阻力(大规模杀伤性武器,0.16;95%CI,0.08-0.24)和显著增加的总鼻腔容积(WMD,0.96;95%CI,0.73-1.19)。任何并发症的发生都没有显着差异。手术后1年以上,鼻塞的改善(大规模杀伤性武器,5.18;95%CI,3.00-7.37),鼻漏(大规模杀伤性武器,3.57;95%CI,1.78-5.37),和打喷嚏(大规模杀伤性武器,2.95;95%CI,1.58-4.32)保持不变。
未经评估:在本系统综述和荟萃分析中,鼻甲手术与AR的阳性结局相关,并且在长期随访期间维持了这种相关性.并发症的发生率也很低。这些发现可以指导考虑进行鼻甲手术的AR患者的术前咨询。
Turbinate surgery is an effective treatment for allergic rhinitis (AR) refractory to medical treatment. However, the long-term outcomes of turbinate surgery are still unclear and have not yet been confirmed by a meta-analysis and systematic
review of the literature.
To investigate the long-term outcomes and safety of turbinate surgery in AR by performing a meta-analysis.
MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.gov were searched through April 2021.
Studies that analyzed turbinate surgery alone, had a follow-up period of more than 1 year, examined long-term efficacy of turbinate surgery, used current turbinate surgery methods, and were published in a peer-reviewed journal were included. Full-text reviews were performed by 2 independent reviewers. Conflicts were resolved by a third reviewer.
Descriptive and quantitative data were extracted; weighted mean difference (WMD) was synthesized under a random-effects model. Heterogeneity was assessed using the Q statistic and the I2 metric. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines.
The long-term outcomes of turbinate surgery on subjective nasal symptoms and objective parameters.
Of the 3962 citations retrieved, 18 studies comprising 1411 patients were included. Findings showed significantly decreased symptom scores in nasal obstruction (WMD, 4.60, 95% CI, 3.43-5.76), rhinorrhea (WMD, 3.12; 95% CI, 1.97-4.28), sneezing (WMD, 2.64; 95% CI, 1.74-3.54), itching (WMD, 1.75; 95% CI, 1.20-2.30), and nasal resistance (WMD, 0.16; 95% CI, 0.08-0.24) and a significant increased total nasal volume (WMD, 0.96; 95% CI, 0.73-1.19). There was no significant difference in the occurrence of any complication. More than 1 year after surgery, the improvements in nasal obstruction (WMD, 5.18; 95% CI, 3.00-7.37), rhinorrhea (WMD, 3.57; 95% CI, 1.78-5.37), and sneezing (WMD, 2.95; 95% CI, 1.58-4.32) were maintained.
In this systematic
review and meta-analysis, turbinate surgery was associated with positive outcomes in AR and maintained the association during long-term follow-up. The rate of complications is also low. These findings can guide the preoperative counseling of patients with AR being considered for turbinate surgery.