The Neoproterozoic carbonate record contains multiple carbon isotope anomalies, which are the subject of intense debate. The largest of these anomalies, the Shuram excursion (SE), occurred in the mid-Ediacaran (~574-567 Ma). Accurately reconstructing marine redox landscape is a clear path toward making sense of the mechanism that drives this δ13 C anomaly. Here, we report new uranium isotopic data from the shallow-marine carbonates of the Wonoka Formation, Flinders Ranges, South Australia, where the SE is well preserved. Our data indicate that the δ238 U trend during the SE is highly reproducible across globally disparate sections from different depositional settings. Previously, it was proposed that the positive shift of δ238 U values during the SE suggests an extensive, near-modern level of marine oxygenation. However, recent publications suggest that the fractionation of uranium isotopes in ferruginous and anoxic conditions is comparable, opening up the possibility of non-unique interpretations of the carbonate uranium isotopic record. Here, we build on this idea by investigating the SE in conjunction with additional geochemical proxies. Using a revised uranium isotope mass balance model and an inverse stochastic carbon cycle model, we reevaluate models for δ13 C and δ238 U trends during the SE. We suggest that global seawater δ238 U values during the SE could be explained by an expansion of ferruginous conditions and do not require a near-modern level of oxygenation during the mid-Ediacaran.

Photovoltaic (PV) technologies are critical for sustainable energy supply, climate change mitigation, and energy security with lower environmental impact compared to other generation alternatives. Despite the environmental benefits of PV technologies, one of these major downsides is the growing concern over the environmental impact due to risks associated with improper waste handling and disposal of decommissioned PV panels. As a result, there are strong incentives for PV panel recycling to recover valuable resources and mitigate risks caused by hazardous substances. This study proposes a reverse logistical planning framework for collecting end-of-life PV panels, which aims to support the integration of existing recycling technologies and collection schemes using a holistic approach for ensuring feasibility and reducing environmental impact. The framework reviews current recycling methodologies for PV waste and the state of PV markets, including PV uptake, waste stream forecast, collection and logistic strategies. Additionally, South Australia is used as the context of analysis for a case study where the framework is applied to identify the potential strategies for handling and collection of end-of-life PV panels based on current PV uptake and waste stream forecast. As a result, capital, transportation and operation costs can be reduced, contributing to lower overall recycling cost for the PV waste treatment and a more efficient reverse logistic system.

Exposure to extreme temperatures is associated with increased emergency department (ED) presentations. The resulting burden on health service costs and the potential impact of climate change is largely unknown. This study examines the temperature-EDs/cost relationships in Adelaide, South Australia and how this may be impacted by increasing temperatures.
A time series analysis using a distributed lag nonlinear model was used to explore the exposure-response relationships. The net-attributable, cold-attributable and heat-attributable ED presentations for temperature-related diseases and costs were calculated for the baseline (2014-2017) and future periods (2034-2037 and 2054-2057) under three climate representative concentration pathways (RCPs).
The baseline heat-attributable ED presentations were estimated to be 3600 (95% empirical CI (eCI) 700 to 6500) with associated cost of $A4.7 million (95% eCI 1.8 to 7.5). Heat-attributable ED presentations and costs were projected to increase during 2030s and 2050s with no change in the cold-attributable burden. Under RCP8.5 and population growth, the increase in heat-attributable burden would be 1.9% (95% eCI 0.8% to 3.0%) for ED presentations and 2.5% (95% eCI 1.3% to 3.7%) for ED costs during 2030s. Under the same conditions, the heat effect is expected to increase by 3.7% (95% eCI 1.7% to 5.6%) for ED presentations and 5.0% (95% eCI 2.6% to 7.1%) for ED costs during 2050s.
Projected climate change is likely to increase heat-attributable emergency presentations and the associated costs in Adelaide. Planning health service resources to meet these changes will be necessary as part of broader risk mitigation strategies and public health adaptation actions.

Since commercial polybrominated diphenyl ethers (PBDEs) have been globally banned or restricted in 2000s, alternative halogenated flame retardants (AHFRs) appear increasingly dominant over PBDEs in many countries/regions. In this study, low levels of AHFRs were unexpectedly observed in the indoor dust from Adelaide, South Australia. Anti-dechlorane plus (anti-DP) was the most frequently detected AHFR with a median concentration of 1.28 ng/g, while other AFHRs were less detected (detection frequency < 50%). The levels of ΣPBDEs (496 ng/g, median) and ΣAHFRs (160 ng/g) and the ratio of ΣAHFRs/ΣPBDEs (0.32) were much lower than those investigated in Australian indoor dust previously. The findings were different to the trend for PBDEs and AHFRs from other countries over the past two decades. No significant correlation was determined between DP and PBDE congeners, indicating their different sources in dust. The human exposure assessment suggested that dust ingestion was the predominant pathway of PBDEs and AHFRs exposure for toddlers, while dermal absorption may be the dominant pathway for adults. The estimated daily intake (EDI) suggested low health risks via dust ingestion and dermal contact for general populations in Adelaide. This study contributes to the knowledge on region-specific FR contamination in indoor environments and related human exposure risk.

Marine sponges are an ideal source for isolating as yet undiscovered microorganisms with some sponges having about 50% of their biomass composed of microbial symbionts. This study used a variety of approaches to investigate the culturable diversity of the sponge-associated bacterial community from samples collected from the South Australian marine environment. Twelve sponge samples were selected from two sites and their bacterial population cultivated using seven different agar media at two temperatures and three oxygen levels over 3 months. These isolates were identified using microscopic, macroscopic, and 16S rRNA gene analysis. A total of 1234 bacterial colonies were isolated which consisted of four phyla: Actinobacteria, Firmicutes, Proteobacteria, and Bacteroidetes, containing 21 genera. The diversity of the bacterial population was demonstrated to be influenced by the type of isolation medium, length of the incubation period and temperature, sponge type, and oxygen level. The findings of this study showed that marine sponges of South Australia can yield considerable bacterial culturable diversity if a comprehensive isolation strategy is implemented. Two sponges, with the highest and the lowest diversity of culturable isolates, were examined using next-generation sequencing to better profile the bacterial population. A marked difference in terms of phyla and genera was observed using culture-based and culture-independent approaches. This observed variation displays the importance of utilizing both methods to reflect a more complete picture of the microbial population of marine sponges. KEY POINTS: Improved bacterial diversity due to long incubations, 2 temperatures, and 3 oxygen levels. Isolates identified by morphology, restriction digests, and 16S rRNA gene sequencing. At least 70% of culturable genera were not revealed by NGS methods.

To examine sociodemographic characteristics and caring experiences associated with being an older rather than younger carer of an adult with a chronic health condition.
The population-based cross-sectional South Australian Health Omnibus survey was administered in 2016. Multiple logistic regression was used to identify sociodemographic characteristics and caring experiences associated with being an older (≥65 years) versus younger (<65 years) carer of one or more adult(s) with a chronic health condition.
Of 988 survey respondents who self-identified as carers, 198(20%) were 65 years or over. Characteristics associated with being an older carer included having a partner, having poor physical health, being born outside Australia, have no formal qualification, living in a household of 1-2 people, have an annual household income ≤$60,000, and owning one\'s home. Carer experiences associated with older carer status included providing ≥40 h of care per week, perceived control over caring, and caring for someone with a neurological condition, whereas caring for someone with a mental illness, reporting poor mental health of their own, and providing personal care were inversely associated.
Interventions directed at older carers should consider the increased likelihood that they may be investing large amounts of time in caring for someone with a neurological condition, and be culturally and linguistically diverse.

The misuse and overuse of antibiotics have led to the emergence of multidrug-resistant microorganisms, which decreases the chance of treating those infected with existing antibiotics. This resistance calls for the search of new antimicrobials from prolific producers of novel natural products including marine sponges. Many of the novel active compounds reported from sponges have originated from their microbial symbionts. Therefore, this study aims to screen for bioactive metabolites from bacteria isolated from sponges. Twelve sponge samples were collected from South Australian marine environments and grown on seven isolation media under four incubation conditions; a total of 1234 bacterial isolates were obtained. Of these, 169 bacteria were tested in media optimized for production of antimicrobial metabolites and screened against eleven human pathogens. Seventy bacteria were found to be active against at least one test bacterial or fungal pathogen, while 37% of the tested bacteria showed activity against Staphylococcus aureus including methicillin-resistant strains and antifungal activity was produced by 21% the isolates. A potential novel active compound was purified possessing inhibitory activity against S. aureus. Using 16S rRNA, the strain was identified as Streptomyces sp. Our study highlights that the marine sponges of South Australia are a rich source of abundant and diverse bacteria producing metabolites with antimicrobial activities against human pathogenic bacteria and fungi.

Although many studies have investigated the correlations between injury severities and seat positions, few researchers explored the correlates of injury severities (e.g., seat positions) within a crash that results in multiple occupant injuries. Therefore, we examine the injury correlates within and between crashes, and study the correlations between seat positions and occupant injury severity by constructing a hierarchical ordered probit model. A total of 20,327 occupant injuries in 16,405 motor vehicle crashes in South Australia (2012 - 2016) are used. The results of this study indicate that the rear left passenger seat is associated with a 7.66% higher chance of getting injured (including moderate and severe injury), and the front left passenger seat is associated with a 2.94% higher chance of getting injured compared with the driver seat. Besides, the higher injury chances for other passenger seats including the rear right and rear middle seats are 4.97% and 4.74%, respectively, compared with the driver seat. Thus, this study offers passengers insightful suggestions about how to protect themselves by choosing the right passenger seat in a vehicle.

The relation of snoring to risks of stroke and other major cardiovascular (CV) events is uncertain.
We aimed to determine associations of snoring patterns and major CV events in relation to OSA among participants of the international Sleep Apnea cardiovascular Endpoints (SAVE) trial.
Post hoc analyses of the SAVE trial, which involved 2,687 patients with coexisting moderate-to-severe OSA and established coronary or cerebral CV disease, who were randomly allocated to CPAP treatment plus usual care or usual care alone, and followed-up for a median 3.5 years. Associations of self-reported snoring patterns (frequency and loudness) and breathing pauses collected on the Berlin questionnaire at baseline and multiple times during follow-up, and adjudicated composites of CV outcomes (primary, CV death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for unstable angina, heart failure, or transient ischemic attack; and separately of cardiac and cerebral events), were evaluated in time-dependent Cox proportional hazards models adjusted for various confounders including the apnea-hypopnea index.
Increase (per category) of snoring frequency (adjusted hazard ratio [HR], 1.10; 95% CI, 1.02-1.20; P = .015), loudness (HR, 1.16; 95% CI, 1.06-1.27; P = .001), and breathing pauses (HR, 1.16; 95% CI, 1.08-1.25; P < .001) at any time point during follow-up were each associated with the primary composite CV outcome. These associations were driven by significant associations for cerebral rather than cardiac events, and positive interactions between the three snoring patterns for cerebral events. There was no significant interaction between CPAP treatment and snoring variables for cerebral events.
Snoring in patients with OSA with established CV disease is associated with greater risks of cerebral but not cardiac events, independent of CPAP treatment and frequency of apnea and hypopnea events.
ClinicalTrials.gov; No.: NCT00738179; URL: www.clinicaltrials.gov.

This study aimed to investigate the occurrences of a suite of thirty-one organophosphate tri-esters (tri-OPEs) and six di-esters (di-OPEs) in house dust collected from Adelaide, South Australia. The results demonstrate ubiquitous presence of most OPEs in Adelaide house dust, with median concentration of 40,200 and 5260 ng/g dry weight for ∑tri-OPEs and ∑di-OPEs, respectively. A number of emerging OPEs with chemical structures resembling that of triphenyl phosphate (TPHP), including bisphenol A bis(diphenyl phosphate) (BPA-BDPP), cresyl diphenyl phosphate (CDP), isodecyl diphenyl phosphate (IDDPP), resorcinol-bis(diphenyl)- phosphate (RDP), as well as a suite of isopropylated or tert-butylated triarylphosphate ester isomers (ITPs or TBPPs), were frequently detected with combined levels surpassing that of TPHP. The investigated di-OPEs, predominated by DPHP, consisted of approximately 13% of the ∑tri-OPEs concentrations. Median concentration ratios of diphenyl phosphate (DPHP) and bis(2-ethylhexyl) phosphate (BEHP) to their respective tri-OPEs [i.e., TPHP and tris(2-ethylhexyl) phosphate (TEHP)] were determined to be 1.8 and 2.0, respectively, indicating possible commercial applications for these two di-OPEs. The estimated human intakes of dust-associated OPEs via dust ingestion and dermal contact were much lower than the reference doses. However, the risks of human exposure to OEPs may be complicated by quickly expanding family of OPEs containing various analogues and isomers as well as additional exposure pathways. Therefore, elucidation of human exposure to OPEs and associated risks requires extensive efforts in analytical, environmental, toxicological, and epidemiological investigations.