目的:我们进行了一项中风发病率试验研究,专注于可行性和纳入顾问报告指南,对未来基于人群的研究的设计进行建模,旨在最终确定中风发病率,前身,治疗,和结果。
方法:前瞻性卒中发生率研究(初步研究)。
方法:所有居住在南澳大利亚和北领地邮政编码定义地区的15岁或以上的人(885472人,包括45127名原住民[5.1%])在2015年10月1日至12月31日期间首次诊断为中风,并入住公立医院或中风和短暂性脑缺血发作诊所。
方法:前瞻性人群卒中发生率研究的可行性。
结果:在123名第一次中风的参与者中,10人为土著人(8%);土著人的平均年龄为45岁(四分位数间距[IQR],33-55岁),73岁的非土著居民(IQR,62-84岁)。对于原住民来说,卒中的年龄标准化发生率为104(95%置信区间[CI],84-124)每100000人年,非土著人民每100000人年33人(95%CI,22-44)。我们发现,在土著人中进行基于人群的前瞻性卒中发病率研究是可行的,包括建立足够的样本量,诊断确认,识别中风事件,确认中风亚型,建立稳定的统计人口,与其他卒中发生率研究比较的标准化数据报告,和伦理研究报告,符合考虑准则。
结论:较大的,以人群为基础的原住民卒中发生率研究既可行,也需要提供对卒中发生率的可靠估计。前身,治疗和结果,以帮助指导减少原住民卒中风险和结果的策略。
We performed a pilot stroke incidence
study, focused on feasibility and inclusion of the CONSIDER reporting guidelines, to model the design of a future population-based
study aiming to definitively determine stroke incidence, antecedents, treatment, and outcomes.
Prospective stroke incidence
study (pilot
study).
All people aged 15 years or older who lived in postcode-defined areas of South Australia and Northern Territory (885 472 people, including 45 127 Aboriginal people [5.1%]) diagnosed with stroke for the first time during 1 October - 31 December 2015 and admitted to public hospitals or stroke and transient ischaemic attack clinics.
Feasibility of a prospective population-based stroke incidence
study.
Of the 123 participants with first strokes, ten were Aboriginal (8%); the median age of Aboriginal people was 45 years (interquartile range [IQR], 33-55 years), of non-Indigenous people 73 years (IQR, 62-84 years). For Aboriginal people, the age-standardised incidence of stroke was 104 (95% confidence interval [CI], 84-124) per 100 000 person-years, for non-Indigenous people 33 (95% CI, 22-44) per 100 000 person-years. We found that a prospective population-based stroke incidence
study in Aboriginal people was feasible, including with respect to establishing an adequate sample size, diagnostic confirmation, identification of incident stroke, confirming stroke subtypes, establishing a stable statistical population, standardising data reporting for comparison with other stroke incidence studies, and ethical research reporting that conforms to CONSIDER guidelines.
A larger, population-based study of the incidence of stroke in Aboriginal people is both feasible and needed to provide robust estimates of stroke incidence, antecedents, treatments and outcomes to help guide strategies for reducing the risk of and outcomes of stroke in Aboriginal people.