目的:探讨不同肿瘤浸润方式对T3声门型喉癌手术治疗预后的影响。
方法:我们对91例T3声门型喉癌患者的临床资料进行回顾性分析。
结果:我们发现后侵犯与环状软骨椎板的受累显著相关(P<0.001),类软骨(P=0.001),和声门下(P=0.001)。全喉切除术(TL)组与部分喉切除术(PL)组的生存结局无统计学差异,但在PL组,前侵犯肿瘤的5年DFS优于后侵犯肿瘤(HR:4.681,95%CI:1.337-16.393,P=0.016),声门下受累与LRRFS恶化相关(HR:3.931,95%CI:1.054-14.658,P=0.041)。同时,我们发现环状软骨层受累是PL患者术后喉狭窄的独立危险因素(HR:11.67,95%CI:1.89-71.98,P=0.008).
结论:选择性进行PL也可以获得与TL相当的良好肿瘤学结果。后侵犯和声门下受累是T3声门型喉癌术后PL复发的独立预后因素,环状软骨层的受累与术后喉狭窄有关。喉癌患者的肿瘤侵袭模式应进一步细分,以选择更个性化的治疗方案。
OBJECTIVE: To investigate the prognostic impact of different tumor invasion patterns in the surgical treatment of T3 glottic laryngeal cancer.
METHODS: We conducted a retrospective analysis of clinical data of 91 patients with T3 glottic laryngeal cancer.
RESULTS: We found that the posterior invasion being significantly associated with involvement of the lamina of cricoid cartilage (P < 0.001), arytenoid cartilage (P = 0.001), and subglottic (P = 0.001). There was no statistical difference in survival outcomes between the total laryngectomy (TL) group and the partial laryngectomy (PL) group, but in the PL group, tumors with anterior invasion were associated with a better 5-year DFS than tumors with posterior invasion (HR: 4.681, 95% CI: 1.337-16.393, P = 0.016), and subglottic involvement was associated with worse LRRFS (HR: 3.931, 95% CI: 1.054-14.658, P = 0.041). At the same time, we found that involvement of the lamina of cricoid cartilage was an independent risk factor for postoperative laryngeal stenosis in PL patients (HR: 11.67, 95% CI: 1.89-71.98, P = 0.008).
CONCLUSIONS: Selectively performed PL can also achieve favorable oncological outcomes comparable to those of TL. Posterior invasion and subglottic involvement are independent prognostic factors for recurrence after PL in T3 glottic laryngeal cancer, and involvement of the lamina of cricoid cartilage is associated with postoperative laryngeal stenosis. The tumor invasion pattern of patients with laryngeal cancer should be further subdivided to allow for selection of a more individualized treatment plan.