Abstract:
Iatrogenic laryngotracheal stenosis (iLTS) is a pathological condition characterized by the narrowing of the laryngeal and tracheal structures due to the formation of abnormal scar tissue. The core of iLTS lies in the fibrosis of the laryngotracheal tissue, and recent research has unveiled novel discoveries regarding the underlying mechanisms of fibrosis. This review provides an overview of the recent advancements in understanding the mechanisms of fibrosis in iLTS. It encompasses various aspects, such as immune system dysregulation, changes in the extracellular matrix (ECM), metabolic alterations, and the role of microbial flora. The review also explores the interplay and relationships between these new mechanisms, establishing a theoretical foundation for the development of multi-target therapies and combination therapies for iLTS.
摘要:
医源性喉气管狭窄(iLTS)是一种病理状况,其特征是由于异常瘢痕组织的形成而导致喉和气管结构变窄。iLTS的核心在于喉气管组织的纤维化,最近的研究揭示了关于纤维化潜在机制的新发现。这篇综述概述了在理解iLTS纤维化机制方面的最新进展。它包括各个方面,比如免疫系统失调,细胞外基质(ECM)的变化,代谢改变,和微生物菌群的作用。审查还探讨了这些新机制之间的相互作用和关系,为开发iLTS的多靶点疗法和联合疗法奠定了理论基础。