传统药用植物已经在民间药物中使用了数十年,用于治疗和管理包括糖尿病在内的多种疾病和疾病。疼痛,溃疡,癌症,和伤口,在其他人中。这项研究的重点是肯尼亚常用的抗糖尿病药用物种的植物化学和抗糖尿病活性。这些物种的植物化学分析显示,类黄酮和萜类化合物是据报道的主要化学类别,与针对上述疾病的强大生物活性有关。在其他人中。然而,在选定的22个物种中,许多天然产物分离研究只关注少数物种,正如研究中强调的那样。来自13种抗糖尿病物种的所有检查过的粗提物均通过抑制α-葡萄糖苷酶和α-淀粉酶等机制表现出强的抗糖尿病活性,而9个尚未评估其抗糖尿病活性。分离化合物S-甲基半胱氨酸亚砜,槲皮素,AlliuacideG,2-(3,4-二羟基苯甲酰基)-2,4,6-三羟基-3(2H)-苯并呋喃酮,木犀草素-7-O-D-吡喃葡萄糖苷,槲皮素,1,3,11α-三羟基-9-(3,5,7-三羟基-4H-1-苯并吡喃-7-2-基)-5α-(3,4-二羟基-苯基)-5,6,11-六氢-5,6,11-三氧萘并-12-酮和[1,3,11α-三羟基-4-四羟基-(3,5-三羟基肯尼亚有大量的成年人患有糖尿病,现有的治疗方法昂贵但效果不佳,本研究通过记录常用的抗糖尿病药用植物,突出了替代疗法。Further,该研究支持这些植物的抗糖尿病使用现有的药理学概况,并突出了研究空白。因此,迫切需要对肯尼亚常用的抗糖尿病物种进行天然产物分离工作,并评估其抗糖尿病活性,在体外和体内,验证它们的抗糖尿病用途并提出新的抗糖尿病药物。
Traditional medicinal plants have been used for decades in folk medicines in the treatment and management of several ailments and diseases including diabetes, pain, ulcers, cancers, and wounds, among others. This study focused on the phytochemical and antidiabetic activity of the commonly used antidiabetic medicinal species in
Kenya. Phytochemical profiling of these species revealed flavonoids and terpenoids as the major chemical classes reported which have been linked with strong biological activities against the aforementioned diseases, among others. However, out of the selected twenty-two species, many of the natural product isolation studies have focused on only a few species, as highlighted in the study. All of the examined crude extracts from thirteen antidiabetic species demonstrated strong antidiabetic activities by inhibiting α-glucosidase and α-amylase among other mechanisms, while nine are yet to be evaluated for their antidiabetic activities. Isolated compounds S-Methylcysteine sulfoxide, quercetin, alliuocide G, 2-(3,4-Dihydroxybenzoyl)-2,4,6-trihydroxy-3 (2H)-benzofuranone, Luteolin-7-O-D-glucopyranoside, quercetin, 1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one and [1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one]-4\'-O-D-gluco-pyranoside from Allium cepa have been found to exhibit significant antidiabetic activities. With the huge number of adults living with diabetes in
Kenya and the available treatment methods being expensive yet not so effective, this study highlights alternative remedies by documenting the commonly used antidiabetic medicinal plants. Further, the study supports the antidiabetic use of these plants with the existing pharmacological profiles and highlights research study gaps. Therefore, it is urgent to conduct natural products isolation work on the selected antidiabetic species commonly used in
Kenya and evaluate their antidiabetic activities, both in vitro and in vivo, to validate their antidiabetic use and come up with new antidiabetic drugs.