背景:盐酸特比萘芬(TEB)是一种广谱抗真菌药物,常用于治疗皮肤真菌感染。本研究设计了一种由离子电渗系统辅助的水凝胶贴剂,以增强TEB的经皮渗透性,能够更深地渗透到皮肤层。方法:电流强度的影响,pH值,使用自适应离子电渗系统对TEB水凝胶贴片的渗透性和药物浓度进行了探索。药代动力学特征,通过离子电渗疗法促进经皮渗透,通过微透析技术的应用进行了分析。采用扫描电子显微镜和透射电子显微镜来评估离子电渗系统对皮肤完整性的影响。结果:TEB水凝胶贴剂8小时内的累积药物积累,在离子电渗疗法的辅助下,是对照组中没有离子电渗辅助和TEB乳膏的2.9倍和7.9倍,分别。离子导入辅助的TEB水凝胶贴剂能显著增加TEB的通透性,AUC(0-8小时)分别是3.4和5.4倍,而Cmax比没有离子电渗的TEB水凝胶贴片高4.2和7.3倍,分别。该系统对深层细胞没有显著影响。结论:该系统可为深部抗真菌感染的局部治疗提供安全有效的临床策略。
Background: Terbinafine hydrochloride (TEB) is a broad-spectrum antifungal medication commonly used to treat fungal infections of the skin. This study designed a hydrogel patch assisted by an
iontophoresis system to enhance the transdermal permeability of TEB, enabling deeper penetration into the skin layers. Methods: The influences of current intensity, pH levels, and drug concentration on the TEB hydrogel patch\'s permeability were explored using an adaptive ion electroosmosis system. The pharmacokinetic profile, facilitated by
iontophoresis for transdermal permeation, was analyzed through the application of microdialysis technology. Scanning electron microscopy and transmission electron microscopy were employed to assess the impact of ion electroosmotic systems on skin integrity. Results: The cumulative drug accumulation within 8 h of the TEB hydrogel patches, assisted by
iontophoresis, was 2.9 and 7.9 times higher than without
iontophoresis assistance and TEB cream in the control group, respectively. TEB hydrogel patches assisted by
iontophoresis can significantly increase the permeability of TEB, and the AUC(0-8 h) was 3.4 and 5.4 times higher, while the Cmax was 4.2 and 7.3 times higher than the TEB hydrogel patches without iontophoresis, respectively. This system has no significant impact on deep-layer cells. Conclusions: This system may offer a safe and effective clinical strategy for the local treatment of deep antifungal infections.