背景与目的牙本质过敏(DH)治疗是牙医在日常临床实践中面临的主要挑战之一。当前的疗法仅提供暂时的缓解,需要多次应用才能显示结果,并且缺乏与这些药物的长期影响相关的证据。纳米羟基磷灰石(n-HA)和pro-argin(8.0%精氨酸-碳酸钙)最近已用于一次性办公室应用的牙本质脱敏,但影响是暂时的。然而,标准治疗方案需要明确或持久的结果。由于离子电渗会放大中性和离子化药物跨膜的运输,这些脱敏剂与离子电渗疗法一起使用可能有利于获得令人满意的结果。进行这项研究是为了评估离子电渗疗法是否可以使纳米羟基磷灰石和前精氨酸更好地渗透到牙本质中,提高和延长他们的治疗效果。材料和方法包括45名20至60岁年龄段的牙本质过敏者。在每个个体中,选择四颗宫颈病变的牙齿(每个象限中的一颗),并随机分为四组:I组:含有纳米羟基磷灰石的脱敏糊剂,第二组:含纳米羟基磷灰石离子导入脱敏膏,第三组:含有pro-argin的脱敏糊剂,和IV组:含有前精氨酸的脱敏糊剂,离子电渗疗法;然后一次性使用药物。通过触觉评估敏感性,鼓风,以及在应用之前和之后立即进行的冷分级热测试(CGTT),一周后,在第一个结束时,第三,第六个月。统计学分析通过重复测量ANOVA进行统计学分析以用于组内比较。使用单因素方差分析和Tukey的事后检验进行组间比较。结果所有组均显示牙本质过敏的统计学显着降低(p<0.001)。通过触觉评估,各组超敏反应的降低可以分为II组(3.578/1.800/1.556)>IV组(3.367/1.755/1.555)>I组(2.3781/1.022/0.822)>III组(2.222/0.911/0.778)。鼓风,和冷分级热测试,分别。在长达6个月的时间内,第二组和第四组的敏感性水平显着降低。结论纳米羟基磷灰石和前精氨酸可有效降低牙本质过敏。离子电渗疗法可以是改善分娩的有价值的辅助手段,提高和延长其有效性。
Background and objectives Dentin hypersensitivity (DH) treatment is one of the main challenges dentists face in their daily clinical practice. Current therapies provide only temporary relief and require multiple applications to exhibit results, and there is a lack of evidence related to the long-term effects of these agents. Nano-hydroxyapatite (n-HA) and pro-argin (8.0% arginine-calcium carbonate) have recently been used for dentin desensitization with a one-time in-office application, but the effects are interim. However, a standard treatment protocol demands definitive or enduring results. Since
iontophoresis amplifies the transport of neutral and ionized drugs across a membrane, the use of these desensitizing agents with
iontophoresis may be beneficial to accomplish satisfactory results. This
study was conducted to evaluate whether
iontophoresis could enable better penetration of nano-hydroxyapatite and pro-argin into the dentin, enhancing and prolonging their therapeutic effect. Materials and methods Forty-five participants with dentin hypersensitivity in the age group of 20 to 60 years were included. In each individual, four teeth with cervical lesions (one from each quadrant) were selected and divided randomly into four groups: group I: desensitizing paste containing nano-hydroxyapatite, group II: desensitizing paste containing nano-hydroxyapatite with iontophoresis, group III: desensitizing paste containing pro-argin, and group IV: desensitizing paste containing pro-argin with
iontophoresis; followed by one-time application of the agents. Sensitivity was assessed by tactile, air blast, and cold-graded thermal tests (CGTTs) before and immediately after application, after one week, and at the end of the first, third, and sixth months. Statistical analysis Statistical analysis was done by repeated measures ANOVA for within-group comparison. Intergroup comparison was done using one-way ANOVA and Tukey\'s post-hoc test. Results All the groups showed a statistically significant reduction in dentin hypersensitivity (p<0.001). The reduction in hypersensitivity in various groups can be graded as group II (3.578/1.800/1.556) > group IV (3.367/1.755/1.555) > group I (2.3781/1.022/0.822) > group III (2.222/0.911/0.778) as evaluated by tactile, air blast, and cold-graded thermal tests, respectively. Group II and group IV presented a significant reduction in sensitivity levels consistent for up to six months. Conclusion Nano-hydroxyapatite and pro-argin can be used effectively for reducing dentin hypersensitivity.
Iontophoresis can be a valuable adjunct for their improved delivery, enhancing and prolonging their effectiveness.