Abstract：
Iontophoretic transdermal drug delivery (TDD) devices are known to enhance the transdermal transport of drugs. However, conventional transdermal iontophoretic devices require external power sources, wired connections, or mechanical parts, which reduce the comfort level for patients during extended use. In this work, a self-powered, wearable transdermal iontophoretic patch (TIP) is proposed by harvesting ambient humidity for energy generation, enabling controlled TDD. This patch primarily uses moist-electric generators (MEGs) as its power source, thus obviating the need for complex power management modules and mechanical components. A single MEG unit can produce an open-circuit voltage of 0.80 V and a short-circuit current of 11.65 µA under the condition of 80% relative humidity. Amplification of the electrical output is feasible by connecting multiple generator units in series and parallel, facilitating the powering of certain commercial electronic devices. Subsequently, the MEG array is integrated with the TDD circuit to create the wearable TIP. After 20 min of application, the depth of drug penetration through the skin is observed to increase threefold. The effective promotion effect of TIP on the transdermal delivery of ionized drugs is corroborated by simulations and experiments. This wearable TIP offers a simple, noninvasive solution for TDD.
摘要：
已知离子电渗经皮药物递送(TDD)装置增强药物的经皮运输。然而,传统的经皮离子电渗设备需要外部电源，有线连接，或机械零件，这降低了患者在长期使用期间的舒适度。在这项工作中,一个自我供电的，可穿戴经皮离子电渗贴剂（TIP）是通过收集环境湿度来产生能量，启用受控TDD。该补丁主要使用湿电发电机（MEG）作为电源，从而避免了对复杂的电源管理模块和机械部件的需要。单个MEG单元在80％相对湿度的条件下可产生0.80V的开路电压和11.65µA的短路电流。通过串联和并联连接多个发电机组来放大电力输出是可行的，促进某些商业电子设备的供电。随后，MEG阵列与TDD电路集成以创建可穿戴TIP。施用20分钟后，观察到药物穿透皮肤的深度增加了三倍。通过模拟和实验证实了TIP对离子化药物经皮递送的有效促进作用。这个可穿戴的TIP提供了一个简单的，TDD的无创解决方案。
