溶栓治疗引起的缺血性中风和缺血/再灌注(I/R)损伤是高死亡率和严重的长期身体和认知障碍的疾病。它们对全球公共卫生产生重大影响。这些疾病与大脑微循环的多次损伤有关,包括活性氧(ROS)过量生产,白细胞粘附和浸润,脑血屏障(BBB)破坏,毛细血管灌注不足,最终导致组织水肿,出血,脑损伤和迟发性神经元损伤。中药已在中国使用,韩国,日本和其他亚洲国家用于治疗多种疾病。在中国,复方中药制剂治疗脑血管疾病的使用可以追溯到汉代。甚至在几千年前,医学处方集记录了许多治疗脑I/R相关疾病的经典处方。本文综述了有关复方中药制剂改善作用的最新信息和潜在机制。中药,和I/R诱导的大脑微循环障碍的活性成分,脑损伤和神经元损伤。
Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in
China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In
China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.