天然产物在癌症免疫疗法中的新兴作用。
关键词: AKT, alpha-serine/threonine-specific protein kinase Adoptive immune-cells transfer immunotherapy B2M, beta-2-microglobulin BMDCs, bone marrow dendritic cells BPS, basil polysaccharide BTLA, B- and T-lymphocyte attenuator CAFs, cancer-associated fibroblasts CCL22, C–C motif chemokine 22 CIKs, cytokine-induced killer cells COX-2, cyclooxygenase-2 CRC, colorectal cancer CTL, cytotoxic T cell CTLA-4, cytotoxic T lymphocyte antigen-4 Cancer immunotherapy Cancer vaccines DAMPs, damage-associated molecular patterns DCs, dendritic cells FDA, US Food and Drug Administration HCC, hepatocellular carcinoma HER-2, human epidermal growth factor receptor-2 HIF-1α, hypoxia-inducible factor-1α HMGB1, high-mobility group box 1 HSPs, heat shock proteins ICD, Immunogenic cell death ICTs, immunological checkpoints IFN-γ, interferon γ IL-10, interleukin-10 Immuno-check points Immunosuppressive microenvironment LLC, Lewis lung cancer MDSCs, myeloid-derived suppressor cells MHC, major histocompatibility complex class MITF, melanogenesis associated transcription factor MMP-9, matrix metalloprotein-9 Mcl-1, myeloid leukemia cell differentiation protein 1 NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NKTs, natural killer T cells NSCLC, non-small cell lung cancer Natural products OVA, ovalbumin PD-1, programmed death-1 PD-L1, programmed death receptor ligand 1 PGE-2, prostaglandin E2 PI3K, phosphoinositide 3-kinase ROS, reactive oxygen species STAT3, signal transducer and activator of transcription 3 TAMs, tumor-associated macrophages TAP, transporters related with antigen processing TGF-β, transforming growth factor-β TILs, tumor infiltration lymphocytes TLR, Toll-like receptor TNF-α, tumor necrosis factor α TSA, tumor specific antigens Teffs, effective T cells Th1, T helper type 1 Tregs, regulatory T cells VEGF, vascular endothelial growth factor bFGF, basic fibroblast growth factor mTOR, mechanistic target of rapamycin
来 源:
DOI:10.1016/j.apsb.2021.08.020
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