关键词： AKT, alpha-serine/threonine-specific protein kinase Adoptive immune-cells transfer immunotherapy B2M, beta-2-microglobulin BMDCs, bone marrow dendritic cells BPS, basil polysaccharide BTLA, B- and T-lymphocyte attenuator CAFs, cancer-associated fibroblasts CCL22, C–C motif chemokine 22 CIKs, cytokine-induced killer cells COX-2, cyclooxygenase-2 CRC, colorectal cancer CTL, cytotoxic T cell CTLA-4, cytotoxic T lymphocyte antigen-4 Cancer immunotherapy Cancer vaccines DAMPs, damage-associated molecular patterns DCs, dendritic cells FDA, US Food and Drug Administration HCC, hepatocellular carcinoma HER-2, human epidermal growth factor receptor-2 HIF-1α, hypoxia-inducible factor-1α HMGB1, high-mobility group box 1 HSPs, heat shock proteins ICD, Immunogenic cell death ICTs, immunological checkpoints IFN-γ, interferon γ IL-10, interleukin-10 Immuno-check points Immunosuppressive microenvironment LLC, Lewis lung cancer MDSCs, myeloid-derived suppressor cells MHC, major histocompatibility complex class MITF, melanogenesis associated transcription factor MMP-9, matrix metalloprotein-9 Mcl-1, myeloid leukemia cell differentiation protein 1 NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NKTs, natural killer T cells NSCLC, non-small cell lung cancer Natural products OVA, ovalbumin PD-1, programmed death-1 PD-L1, programmed death receptor ligand 1 PGE-2, prostaglandin E2 PI3K, phosphoinositide 3-kinase ROS, reactive oxygen species STAT3, signal transducer and activator of transcription 3 TAMs, tumor-associated macrophages TAP, transporters related with antigen processing TGF-β, transforming growth factor-β TILs, tumor infiltration lymphocytes TLR, Toll-like receptor TNF-α, tumor necrosis factor α TSA, tumor specific antigens Teffs, effective T cells Th1, T helper type 1 Tregs, regulatory T cells VEGF, vascular endothelial growth factor bFGF, basic fibroblast growth factor mTOR, mechanistic target of rapamycin

来  源：   DOI：10.1016/j.apsb.2021.08.020   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Cancer immunotherapy has become a new generation of anti-tumor treatment, but its indications still focus on several types of tumors that are sensitive to the immune system. Therefore, effective strategies that can expand its indications and enhance its efficiency become the key element for the further development of cancer immunotherapy. Natural products are reported to have this effect on cancer immunotherapy, including cancer vaccines, immune-check points inhibitors, and adoptive immune-cells therapy. And the mechanism of that is mainly attributed to the remodeling of the tumor-immunosuppressive microenvironment, which is the key factor that assists tumor to avoid the recognition and attack from immune system and cancer immunotherapy. Therefore, this review summarizes and concludes the natural products that reportedly improve cancer immunotherapy and investigates the mechanism. And we found that saponins, polysaccharides, and flavonoids are mainly three categories of natural products, which reflected significant effects combined with cancer immunotherapy through reversing the tumor-immunosuppressive microenvironment. Besides, this review also collected the studies about nano-technology used to improve the disadvantages of natural products. All of these studies showed the great potential of natural products in cancer immunotherapy.
摘要：
肿瘤免疫治疗已成为新一代抗肿瘤治疗,但是它的适应症仍然集中在对免疫系统敏感的几种类型的肿瘤上。因此,扩大适应证、提高疗效的有效策略成为肿瘤免疫治疗进一步发展的关键要素。据报道，天然产物对癌症免疫疗法有这种作用，包括癌症疫苗，免疫检查点抑制剂，和过继免疫细胞疗法。其机制主要归因于肿瘤免疫抑制微环境的重塑，是帮助肿瘤避免免疫系统和癌症免疫疗法识别和攻击的关键因素。因此,这篇综述总结并总结了据报道可改善癌症免疫治疗的天然产物，并研究了其机制。我们发现皂苷，多糖，黄酮类化合物主要是三类天然产物，这反映了通过逆转肿瘤免疫抑制微环境与癌症免疫治疗相结合的显着效果。此外,这篇综述还收集了有关纳米技术用于改善天然产物缺点的研究。所有这些研究都显示了天然产物在癌症免疫疗法中的巨大潜力。
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