Digital technologies

数字技术
  • 文章类型: Journal Article
    背景:数字健康干预(DHIs)已显示出治疗慢性伤口的有希望的结果。然而,与常规护理相比,其有效性以及干预类型的差异是否会影响伤口结局尚不清楚.
    目的:主要目的是确定DHIs对成年慢性伤口患者伤口愈合结果的有效性。次要目标是评估各种类型的DHI之间的伤口愈合结果是否存在任何变化。
    方法:总共,截至2023年8月1日,共检索了9个数据库的文献。随机对照试验(RCT),队列研究,纳入了比较DHIs与对照组在改善慢性伤口成年患者伤口结局方面的功效的准实验研究。研究选择,数据提取,偏倚风险评估由2名评审员独立进行.我们评估了每个RCT的质量,队列研究,分别使用Cochrane偏差风险工具进行准实验研究,Robins-I,和JoannaBriggs研究所关键评估工具清单。使用随机效应模型将相对风险(RR)和95%CI合并,异质性由I2统计量评估。同时进行亚组分析和敏感性分析。
    结果:本系统综述共纳入25项研究,共8125例患者,而只有20项包含6535例患者的研究被纳入荟萃分析.RCT的疗效结果显示,DHI组和对照组在伤口愈合(RR1.02,95%CI0.93-1.12;P=.67)和1年左右的全因死亡率(RR1.08,95%CI0.55-2.12;P=.83)方面没有显着差异。与对照组相比,DHIs的使用与不良事件的显著变化相关(RR0.44,95%CI0.22-0.89;P=.02).亚组分析表明,数字平台在改善伤口愈合方面具有积极作用(RR2.19,95%CI1.35-3.56;P=.002)。尽管在伤口大小方面无法进行荟萃分析,成本分析,患者满意度,和伤口报告率,大多数研究仍然表明,DHI在处理慢性伤口方面并不逊色于常规护理。
    结论:我们的研究结果证明了采用DHI治疗慢性伤口的可行性。然而,更突出,需要高质量的RCT来加强证据,需要更详细的临床疗效研究。
    背景:PROSPEROCRD42023392415;https://tinyurl.com/4ybz6bs9。
    BACKGROUND: Digital health interventions (DHIs) have shown promising results for the management of chronic wounds. However, its effectiveness compared to usual care and whether variability in the type of intervention affects wound outcomes are unclear.
    OBJECTIVE: The main objective was to determine the effectiveness of DHIs on wound healing outcomes in adult patients with chronic wounds. The secondary objectives were to assess if there was any variation in wound healing outcomes across the various types of DHIs.
    METHODS: In total, 9 databases were searched for the literature up to August 1, 2023. Randomized controlled trials (RCTs), cohort studies, and quasi-experimental studies comparing the efficacy of DHIs with controls in improving wound outcomes in adult patients with chronic wounds were included. Study selection, data extraction, and risk of bias assessment were conducted independently by 2 reviewers. We assessed the quality of each RCT, cohort study, and quasi-experimental study separately using the Cochrane risk of bias tool, ROBINS-I, and the Joanna Briggs Institute Critical Appraisal tools checklists. Relative risks (RRs) and 95% CIs were pooled using the random effects model, and heterogeneity was assessed by the I2 statistic. Subgroup analysis and sensitivity analysis were also performed.
    RESULTS: A total of 25 studies with 8125 patients were included in this systematic review, while only 20 studies with 6535 patients were included in the meta-analysis. Efficacy outcomes in RCTs showed no significant differences between the DHIs and control groups in terms of wound healing (RR 1.02, 95% CI 0.93-1.12; P=.67) and all-cause mortality around 1 year (RR 1.08, 95% CI 0.55-2.12; P=.83). Compared with the control group, the use of DHIs was associated with significant changes in adverse events (RR 0.44, 95% CI 0.22-0.89; P=.02). Subgroup analysis suggested a positive effect of the digital platforms in improving wound healing (RR 2.19, 95% CI 1.35-3.56; P=.002). Although meta-analysis was not possible in terms of wound size, cost analysis, patient satisfaction, and wound reporting rates, most studies still demonstrated that DHIs were not inferior to usual care in managing chronic wounds.
    CONCLUSIONS: The findings of our study demonstrate the viability of adopting DHIs to manage chronic wounds. However, more prominent, high-quality RCTs are needed to strengthen the evidence, and more detailed clinical efficacy research is required.
    BACKGROUND: PROSPERO CRD42023392415; https://tinyurl.com/4ybz6bs9.
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  • 文章类型: Journal Article
    目的:探讨矿化牙本质基质(MDM)对冠状动脉切除术后骨再生和保留根迁移的预后影响。
    方法:根据冠状动脉切除术后的植骨类型将患者分为三组:C组(n=20,胶原蛋白),T组(n=20,磷酸三钙(TCP)胶原蛋白),和D组(n=20,MDM+胶原)。CBCT扫描,手术后立即和6个月进行,使用数字软件进行了分析。主要结果,包括骨缺损深度和保留根迁移距离的变化,术后6个月进行评估。
    结果:6个月后,与C组相比,D组和T组的骨缺损减少更大,保留的根迁移减少更少(p<0.001)。D组远端2mm的再生骨体积更大(73mm3vs.57mm3,p=0.011)和较小的根部迁移(2.18mmvs.2.96mm,p<0.001)高于T组。D组完全骨包埋保留根的比例也高于C组(70.0%vs.42.1%,p=0.003)。
    结论:MDM是改善骨缺损愈合和减少冠状动脉切除术后保留的根部迁移的合适移植材料。
    结论:MDM是一种自生材料制备的椅子,这可以显着改善骨愈合,并降低保留根重新萌出的风险。MDM有望成为M3M冠状动脉切除术后的常规骨替代材料。
    OBJECTIVE: To investigate the impact of mineralized dentin matrix (MDM) on the prognosis on bone regeneration and migration of retained roots after coronectomy.
    METHODS: Patients were divided into three groups based on the type of bone graft after coronectomy: Group C (n = 20, collagen), Group T (n = 20, tricalcium phosphate (TCP) + collagen), and Group D (n = 20, MDM + collagen). CBCT scans, conducted immediately and 6 months after surgery, were analyzed using digital software. Primary outcomes, including changes in bone defect depth and retained root migration distance, were evaluated 6 months after surgery.
    RESULTS: After 6 months, both Groups D and T exhibited greater reduction of the bone defect and lesser retained root migration than Group C (p < 0.001). Group D had greater regenerated bone volume in the distal 2 mm (73 mm3 vs. 57 mm3, p = 0.011) and lesser root migration (2.18 mm vs. 2.96 mm, p < 0.001) than Group T. The proportion of completely bone embedded retained roots was also greater in Group D than in Group C (70.0% vs. 42.1%, p = 0.003).
    CONCLUSIONS: MDM is an appropriate graft material for improving bone defect healing and reducing retained root migration after coronectomy.
    CONCLUSIONS: MDM is an autogenous material prepared chairside, which can significantly improve bone healing and reduce the risk of retained root re-eruption. MDM holds promise as a routine bone substitute material after M3M coronectomy.
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  • 文章类型: Journal Article
    背景:通过智能手机扫描应用程序(SSA)进行的面部扫描越来越多地用于具有成本效益的医疗应用,椅子的方法。然而,缺乏临床验证。这篇综述旨在解决:(1)哪种SSA可以进行面部扫描?(2)哪种SSA可以在临床上使用?(3)哪些SSA已被报道并经过科学验证可用于医疗应用?
    方法:在Google上对设计用于面部或物体扫描的SSA进行了技术搜索,苹果AppStore,和GooglePlay商店从2022年8月到2023年12月。文献检索在PubMed上进行,科克伦,EMBASE,MEDLINE,Scopus,IEEEXplore,ACM数字图书馆,Clinicaltrials.gov,ICTRP(WHO)和截至2023年的预印本。资格标准包括英语撰写的科学文章,其中至少包含一种用于临床目的的SSA。SSA选择和数据提取由一名审阅者执行,通过秒验证,第三审稿人因不一致而被咨询。
    结果:检索了63个用于三维物体扫描的应用程序,52目前提供面部扫描功能。56篇科学论文,包括两份病例报告,分析了16项概念验证和38项实验研究。13个应用程序(123DCatch,3D造物主,Bellus3D牙科专业版,Bellus3DFace应用程序,Bellus3DFaceMaker,捕获,Heges,Metascan,Polycam,ScandyPro,Scaniverse,Taptap和Trnio)在文献中报道了数字工作流集成,比较或概念验证研究。
    结论:52种SSA目前可以进行面部扫描,可用于临床,提供成本效益,便携性和用户友好性。尽管临床验证至关重要,只有13个SSA得到了科学验证,潜在的陷阱和局限性的潜在认识。
    BACKGROUND: Facial scanning through smartphone scanning applications (SSA) is increasingly being used for medical applications as cost-effective, chairside method. However, clinical validation is lacking. This review aims to address: (1) Which SSA could perform facial scanning? (2) Which SSA can be clinically used? (3) Which SSA have been reported and scientifically validated for medical applications?
    METHODS: Technical search for SSA designed for face or object scanning was conducted on Google, Apple App Store, and Google Play Store from August 2022 to December 2023. Literature search was performed on PubMed, Cochrane, EMBASE, MEDLINE, Scopus, IEEE Xplore, ACM Digital Library, Clinicaltrials.gov, ICTRP (WHO) and preprints up to 2023. Eligibility criteria included English-written scientific articles incorporating at least one SSA for clinical purposes. SSA selection and data extraction were executed by one reviewer, validated by second, with third reviewer being consulted for discordances.
    RESULTS: Sixty-three applications designed for three-dimensional object scanning were retrieved, with 52 currently offering facial scanning capabilities. Fifty-six scientific articles, comprising two case reports, 16 proof-of-concepts and 38 experimental studies were analysed. Thirteen applications (123D Catch, 3D Creator, Bellus 3D Dental Pro, Bellus 3D Face app, Bellus 3D Face Maker, Capture, Heges, Metascan, Polycam, Scandy Pro, Scaniverse, Tap tap tap and Trnio) were reported in literature for digital workflow integration, comparison or proof-of-concept studies.
    CONCLUSIONS: Fifty-two SSA can perform facial scanning currently and can be used clinically, offering cost-effectiveness, portability and user-friendliness. Although clinical validation is crucial, only 13 SSA were scientifically validated, underlying awareness of potential pitfalls and limitations.
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  • 文章类型: Journal Article
    数字技术已经成为牙科植入的变革性工具,深刻地提高了多个方面的准确性和有效性,如诊断,术前治疗计划,外科手术,和恢复交付。射线照相数据和口内数据的多重集成,有时通过虚拟计划软件使用面部扫描数据或电子脸弓,能够对硬软组织和未来修复的位置进行全面的三维可视化,导致诊断精度提高。在虚拟手术设计中,假体布置和个体解剖细节的结合使得关键程序的虚拟执行(例如,植入物放置,扩展应用程序,等。)通过分析横截面图像和三维表面模型的重建。经过验证,包括模板在内的数字技术的利用,导航,组合技术,植入机器人实现了将虚拟治疗计划无缝转移到实际手术部位,最终导致增强的手术结果和高度改进的准确性。在修复交付中,数字印模技术,阴影匹配,假体制造有了进步,实现无缝数字数据转换和临床医生和技术人员之间的有效沟通。与临床医学相比,牙科种植中的人工智能(AI)技术主要集中在诊断和预测上。人工智能支持的术前计划和手术仍处于发展阶段,由于临床病例的复杂性和伦理考虑,从而限制了广泛采用。
    Digital technology has emerged as a transformative tool in dental implantation, profoundly enhancing accuracy and effectiveness across multiple facets, such as diagnosis, preoperative treatment planning, surgical procedures, and restoration delivery. The multiple integration of radiographic data and intraoral data, sometimes with facial scan data or electronic facebow through virtual planning software, enables comprehensive 3-dimensional visualization of the hard and soft tissue and the position of future restoration, resulting in heightened diagnostic precision. In virtual surgery design, the incorporation of both prosthetic arrangement and individual anatomical details enables the virtual execution of critical procedures (e.g., implant placement, extended applications, etc.) through analysis of cross-sectional images and the reconstruction of 3-dimensional surface models. After verification, the utilization of digital technology including templates, navigation, combined techniques, and implant robots achieved seamless transfer of the virtual treatment plan to the actual surgical sites, ultimately leading to enhanced surgical outcomes with highly improved accuracy. In restoration delivery, digital techniques for impression, shade matching, and prosthesis fabrication have advanced, enabling seamless digital data conversion and efficient communication among clinicians and technicians. Compared with clinical medicine, artificial intelligence (AI) technology in dental implantology primarily focuses on diagnosis and prediction. AI-supported preoperative planning and surgery remain in developmental phases, impeded by the complexity of clinical cases and ethical considerations, thereby constraining widespread adoption.
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  • 文章类型: Journal Article
    本研究深入研究了中小型企业(SME)将数字技术嵌入其商业模式的策略,旨在达到碳中和。我们对五个高科技中小企业进行了全面分析,揭示了一个进化过程模型,突出了他们集成技术的旅程。整合过程分为三个渐进阶段。最初,数字技术被视为促进创新商业模式诞生的“推动者”,本质上转变价值创造的机制,delivery,和捕获。随着中小企业发展到中间阶段,数字技术成为“破坏者”,在如何创造价值方面重塑和重塑商业模式,已交付,并被捕获。进入成熟期,数字技术被提升为“专业知识”的角色,导致一个完善的商业模式,完善和优化这些方面的价值。这些商业模式创新对碳中和的影响是复杂的,并且随着每个阶段的变化而明显。反映数字技术和商业模式演变之间的动态相互作用。
    This study delves into the strategies employed by small and medium-sized enterprises (SMEs) to embed digital technology into their business models, aiming to reach carbon neutrality. We offer a comprehensive analysis of five high technology SMEs, unveiling an evolutionary process model that highlights their journey toward integrating technology. The integration process is delineated into three progressive stages. Initially, digital technology is seen as an \'enabler\' that promotes the birth of an innovative business model, essentially transforming the mechanisms of value creation, delivery, and capture. As SMEs evolve to an intermediate stage, digital technology becomes a \'disruptor\', reshaping and reinventing the business model in terms of how value is created, delivered, and captured. Entering the maturity stage, digital technology is elevated to the role of \'expertise\', leading to a sophisticated business model that refines and optimizes these aspects of value. The influence of these business model innovations on carbon neutrality is complex and varies distinctly with each stage, reflecting the dynamic interplay between digital technology and business model evolution.
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  • 文章类型: Journal Article
    尽管数字技术激增,但全球组织在实现可持续绩效方面仍面临挑战。面对大量的新发明,企业必须投资于数字能力,以确保可持续的市场表现。今天,确保有弹性的未来要求企业专注于数字灵巧能力(即,开采和勘探),数字化战略采用,和数字化转型。这项研究调查了数字能力和数字化战略之间的复杂动态及其对可持续业务绩效的影响。该研究采用问卷驱动的方法从行业内的管理人员那里收集数据。结果表明,数字开发和勘探能力显着提高了可持续的业务绩效。该研究还确定了采用数字化战略对企业绩效和创新的有益影响。市场驱动的商业模式创新成为关键因素,不仅推动可持续绩效,而且还充当各种数字战略与业务成功之间的中介纽带。此外,该研究强调了数字领导能力的重要性,进一步加强创新商业模式与可持续绩效的关系。调查结果强调了数字能力和战略数字化在当今数字驱动的商业环境中促进可持续和创新实践的协同效应。
    Global organizations are still facing challenges in achieving sustainable performance despite the surge in digital technologies. It is imperative that firms invest in digital capabilities to secure sustainable market performance in the face of a barrage of novel inventions. Today, ensuring a resilient future demands business to focus on digital ambidexterity capabilities (i.e., exploitation and exploration), digitalized strategy adoption, and digital transformation. This study investigates the intricate dynamics between digital capabilities and digitalization strategies and their impact on sustainable business performance. The research employed a questionnaire-driven methodology to gather data from managerial personnel within industries. Results show that digital exploitation and exploration capabilities significantly enhance sustainable business performance. The research also establishes the beneficial effect of adopting a digitalization strategy on business performance and innovation. Market-driven business model innovation emerges as a critical factor, not only driving sustainable performance but also serving as a mediating link between various digital strategies and business success. Moreover, the study highlights the importance of digital leadership capabilities, further strengthening the relationship between innovative business models and sustainable performance. The findings underscore the synergistic effect of digital competencies and strategic digitalization in promoting sustainable and innovative practices in today\'s digital-driven business landscape.
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  • 文章类型: Journal Article
    数字技术已成为产业转型和资源利用的关键驱动力。然而,关于数字技术与能源利用之间的确切关系尚未达成共识。本研究采用综合指标体系研究了数字技术对我国30个省份能源利用的影响。结果揭示了中国数字技术与能源效率之间的非线性关系(用N曲线表示),通过稳健性测试进行了验证。这表明数字技术在其最初的快速稳定发展阶段对提高能源效率产生了快速-缓慢-快速的影响。地理上,这种影响在中国东部和中部更为明显,以及能源效率较低的地区。此外,数字技术对总能耗的影响可以表现为倒N形曲线。随着区域能源效率的提高,随着数字技术的发展,能源消耗逐渐减少。这些发现可以为提高能源效率提供有价值的见解,并为制定能源和数字技术政策提供实际指导。
    Digital technology has become a key driver of industrial transformation and resource utilization. However, no consensus has been reached on the exact relationship between digital technology and energy utilization. This study adopted a comprehensive index system to investigate the impact of digital technologies on energy utilization across 30 provinces in China. The results reveal a non-linear relationship between digital technologies and energy efficiency in China (represented by an N-curve), which is validated by robustness tests. This indicates digital technology exerts a fast-slow-rapid impact on improving energy efficiency throughout its initial-rapid-stable developmental stages. Geographically, this effect is more pronounced in eastern and central China, as well as in areas with lower energy efficiency. Furthermore, the impact of digital technology on total energy consumption can be characterized by an inverted N-shaped curve. As regional energy efficiency improves, the energy consumption associated with the development of digital technologies gradually decreases. These findings can contribute valuable insights for enhancing energy efficiency and provide practical guidance for the formulation of energy and digital technology policies.
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  • 文章类型: Journal Article
    目的:研究使用矿化牙本质基质保存牙槽嵴后双壁骨缺损的骨愈合。
    方法:在12只小猎犬的一个外侧下颌骨上拔除第二和第四前磨牙(P2,P4)后,在P2和P4的剩余内侧根部的远端手术产生了两壁骨缺损(5×5×5mm)。共24个部位随机分为三组(植入材料-执行时间):矿化牙本质基质(MDM)-3m(MDM胶原膜;3个月),MDM-6m(MDM颗粒+胶原膜;6个月),和C-6m(仅胶原膜;6个月)。临床,射线照相,数字,术后3个月和6个月进行组织学检查。
    结果:与对照组相比,MDM组的骨愈合更好(总再生骨体积:25.12mm3与13.30mm3,p=.046;小梁体积/总体积:58.84%vs.39.18%,p=.001;新骨形成率:44.13%vs.31.88%,p=.047)。垂直,MDM-6m组骨缺损的放射骨水平高于C-6m组(骨缺损的垂直高度:1.55mmvs.2.74mm,p=.018)。水平,MDM组和C组之间在牙槽脊以下任何时间或任何水平的颊舌骨宽度均未发现显着差异。MDM-3m组和MDM-6m组的剩余MDM百分比均<1%。
    结论:MDM可改善双壁骨缺损的骨愈合,可被视为拔牙后使用的牙槽填充材料。
    OBJECTIVE: To study bone healing of two-wall bone defects after alveolar ridge preservation using mineralized dentin matrix.
    METHODS: After distal roots extraction of second and fourth premolars (P2, P4) on one lateral mandible in 12 beagles, two-wall bone defects (5 × 5 × 5 mm) were surgically created distally to the remaining mesial roots of P2 and P4. A total of 24 sites were randomly allocated to three groups (implant material- time of execution): mineralized dentin matrix (MDM)-3 m (MDM + collagen membrane; 3 months), MDM-6 m (MDM particles + collagen membrane; 6 months), and C-6 m (collagen membrane only; 6 months). Clinical, radiographic, digital, and histological examinations were performed 3 and 6 months after surgery.
    RESULTS: The bone healing in MDM groups were better compared to Control group (volume of bone regenerated in total: 25.12 mm3 vs. 13.30 mm3, p = .046; trabecular volume/total volume: 58.84% vs. 39.18%, p = .001; new bone formation rate: 44.13% vs. 31.88%, p = .047). Vertically, the radiological bone level of bone defect in MDM-6 m group was higher than that in C-6 m group (vertical height of bone defect: 1.55 mm vs. 2.74 mm, p = .018). Horizontally, no significant differences in buccolingual bone width were found between MDM and C groups at any time or at any level below the alveolar ridge. The percentages of remaining MDM were <1% in both MDM-3 m and MDM-6 m groups.
    CONCLUSIONS: MDM improved bone healing of two-wall bone defects and might be considered as a socket fill material used following tooth extraction.
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  • 文章类型: Journal Article
    中小型企业(SME)一直对经济的国内生产总值(GDP)做出重大贡献。通过提高生产率和优化资源利用率来减轻公司运营的不利影响,促使组织实现可持续绩效。为了实现这一目标,企业正在尽一切努力开发系统,以确保可持续的表现。基于普遍存在的研究空白,当前的研究考察了负责任的数字技术组合(DT)的作用,这提供了竞争优势,有助于实现可持续的公司业绩(SFP)。使用简单的随机抽样技术,收集了294家纺织制造业中小企业的数据,并使用AMOS第24版的结构方程模型(SEM)进行了分析。结果表明,数字技术,避税,绿色员工行为,企业社会责任促进了中小企业SFP的改善。此外,值得注意的是,连接TA和SFP的链路不受针对环境的CSR活动的影响。这个发现,然而,不应该降低TA的重要性,这值得管理层的高度重视和思考。
    Small- and medium-sized enterprises (SMEs) have consistently contributed significantly to the economy\'s gross domestic product (GDP). Organizations are motivated to achieve sustainable performance by mitigating the adverse impacts of company operations by improving productivity and optimizing resource utilization. In order to achieve this objective, the businesses are making all their efforts and developing the systems to ensure sustainable performance. Based on the prevailing research gaps, the current study examines the role of a portfolio of responsible digital technologies (DT), which provides a competitive advantage and helps achieve sustainable firm performance (SFP). Using a simple random sampling technique, data from 294 textile manufacturing SMEs is collected and analyzed using the structural equation model (SEM) in AMOS v.24. The results indicated that digital technologies, tax avoidance, green employee behavior, and corporate social responsibility facilitated improving the SFP of SMEs. Furthermore, it is worth noting that the link connecting TA and SFP is unaffected by CSR activities aimed at the environment. This finding, however, should not lessen the importance of TA, which deserves significant attention and thought from management.
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  • 文章类型: Journal Article
    化肥和农药是重要的农业临盆物资。过度使用化肥和农药会造成负面影响,如农产品质量下降和生态环境破坏。提高化肥和农药的效率是加快农业绿色转型的重要一步。使用2015年中国家庭金融调查的数据,本文分析了互联网使用对农民化肥和农药的影响,以及借助倾向得分匹配法和工具变量法的作用背后的机制。研究发现:(1)与不使用互联网的农民相比,使用互联网的农民对化肥和农药的投入更大。(2)不使用互联网的农民的化肥和农药投入将增加21.9%和47.7%,分别,如果他们在反事实假设下使用互联网。(3)在异质性分析中,互联网使用对我国东部地区化肥和农药的投入具有积极而显著的作用,和互联网使用对中西部地区农药投入的影响大于对化肥的影响。(4)互联网使用在较低的规模和较高的规模经营下对化肥和农药投入都有积极而显著的影响,并且在中等规模的运营中具有积极但不显著的效果。
    Fertilizers and pesticides are important agricultural production materials. Excessive use of fertilizers and pesticides can cause negative impacts such as decline in the quality of farm products and damage to the ecological environment. Increasing the efficiency of fertilizers and pesticides is an important step to accelerate the green transformation of agriculture. Using data from the 2015 China Household Finance Survey, this paper analyzes the impacts of Internet use on fertilizers and pesticides by farmers, and the mechanism behind the action with the help of the propensity score matching method and the instrumental variable method. The findings are: (1) Farmers who use the Internet have greater inputs of fertilizers and pesticides compared to farmers who do not use the Internet. (2) Farmers who do not use the Internet would have their inputs of fertilizers and pesticides increased by 21.9% and 47.7%, respectively, if they had used the Internet under the counterfactual hypothesis. (3) In the heterogeneity analysis, Internet use plays a positive and significant role in the inputs of fertilizer and pesticide in the eastern part of China, and Internet use has greater impact on pesticide inputs than on fertilizer in central and western regions. (4) Internet use has a positive and significant effect on fertilizer and pesticide inputs in both lower scale and higher scale operations, and a positive but not significant effect in moderate-scale operations.
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