■探讨FGA基因多态性与川崎病冠状动脉病变的相关性。
■230名川崎病患儿(KD组),纳入200例健康儿童(正常组)和208例非KD发热儿童(发热组)。一般临床指标,血清MMPs的浓度,TIMP-1,FG-α,纤维蛋白原水平,分子功能(FMPV/ODmax)和FGAThr312Ala多态性在早晨禁食后通过检测外周静脉血单独检测。
■三组之间的平均年龄没有显着差异,3.03±1.22年,3.17±1.30年,3.21±1.31年,分别。与发热组相比,白细胞计数(WBC)的水平,血小板计数(PLT),降钙素原(PCT),C反应蛋白(CRP),红细胞沉降率(ESR),白细胞介素-6(IL-6),单核细胞趋化蛋白-1(MCP-1),KD组纤维蛋白原(Fg)水平明显升高。红细胞计数(RBC)和血红卵白(Hb)程度显著下降(p<0.05)。血清MMPs的浓度,KD组和发热组TIMP-1、FG-α明显高于正常组(p<0.05)。KD组MMP-2、MMP-3、MMP-9、MMP-13、TIMP-1、FG-α浓度明显高于发热组(p<0.05)。KD组分为两个亚组,55例合并CAL的患者和179例未合并CAL的患者。联合CAL组血浆纤维蛋白原浓度明显高于非联合CAL组和正常组(p<0.01)。三组间FMPV/ODmax差异无统计学意义(p>0.05)。与正常组相比,FGAGG,GA,AA基因型和G,FGA基因多态性的A等位基因频率在KD组中无显著差别(p>0.05)。在KD组,CAL儿童中最常见的类型是GA,而无CAL儿童中最常见的类型是GG。
■在KD患者中MMPs和FG-α显著上调。CAL患儿FGA基因型的比例明显高于无CAL患儿,提示FGA基因多态性影响KD患儿冠状动脉病变。
UNASSIGNED: To investigate the correlation between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease.
UNASSIGNED: Two hundred and thirty four children with Kawasaki disease (KD group), 200 healthy children (normal group) and 208 children with non-KD fever (fever group) were enrolled. General clinical indicators, the concentration of serum MMPs, TIMP-1, FG-α,fibrinogen level, molecular function (FMPV/ODmax) and FGA Thr312Ala polymorphism were detected individually by testing peripheral venous blood after fasting in the morning.
UNASSIGNED: There was no significant difference in average age among the three groups, which were 3.03 ± 1.22 years, 3.17 ± 1.30 years, and 3.21 ± 1.31 years, respectively. Compared with those in the fever group, the levels of white blood cell count (WBC), platelet count (PLT), procalcitonin (PCT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and fibrinogen (Fg) levels were significantly increased in the KD group. Red blood cell count (RBC) and hemoglobin (Hb) levels were significantly decreased (p < 0.05).The concentration of serum MMPs, TIMP-1, and FG-α in the KD and fever groups were significantly higher than those in the normal group (p < 0.05). The concentration of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and FG-α in the KD group were significantly higher than those in the fever group (p < 0.05).The KD group was divided into two subgroups,55 patients with combined CAL and 179 patients without combined CAL. The plasma fibrinogen concentration in the combined CAL group was significantly higher than that in the non-combined CAL and normal groups (p < 0.01). There was no statistically significant difference in FMPV/ODmax among the three groups (p > 0.05). Compared with normal group, the FGA GG, GA, and AA genotype and G, A allele frequency of the FGA gene polymorphism in the KD group showed no significant difference (p > 0.05). In the KD group, the most common type in children with CAL was GA, while the most common type in children without CAL was GG.
UNASSIGNED: MMPs and FG-α were significantly upregulated in KD patients. The proportion of FGA genotype GA in children with CAL was significantly higher than that in children without CAL, suggesting that FGA gene polymorphisms affect coronary artery lesion in children with KD.