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Abstract：
OBJECTIVE: To evaluate the relationships between serum plasminogen activator (PA) and D-dimer levels, the severity of Kawasaki disease (KD) in children, and their ability to predict coronary artery lesions (CAL).
METHODS: This retrospective study analyzed the clinical data of 102 children diagnosed with KD at the Affiliated Hospital of Jiangnan University from January 2020 to September 2023. The cohort was divided into two groups: 31 children with CAL in the CAL group and 71 without it in the non-CAL group. The study assessed the incidence of CAL and investigated the correlations between serum PA and D-dimer levels and various inflammatory markers (white blood cell (WBC) count, platelet count, and erythrocyte sedimentation rate (ESR)). Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of these biomarkers for CAL.
RESULTS: CAL was present in 30.04% of the children. Pearson correlation analysis revealed that serum PA levels were inversely correlated with WBC count (P = 0.0187), platelet count (P = 0.0116), and ESR (P = 0.0041), while D-dimer levels were positively correlated with these markers (P < 0.001). A negative correlation between PA and D-dimer levels was also observed (P < 0.001). The combined use of PA and D-dimer levels to predict CAL achieved an area under the curve of 0.871.
CONCLUSIONS: Serum PA levels were negatively associated with the severity of KD, whereas D-dimer levels were positively associated. Together, these markers showed significant predictive value for CAL, highlighting their utility in assessing disease severity and guiding management in children with KD.
METHODS: This retrospective study analyzed the clinical data of 102 children diagnosed with KD at the Affiliated Hospital of Jiangnan University from January 2020 to September 2023. The cohort was divided into two groups: 31 children with CAL in the CAL group and 71 without it in the non-CAL group. The study assessed the incidence of CAL and investigated the correlations between serum PA and D-dimer levels and various inflammatory markers (white blood cell (WBC) count, platelet count, and erythrocyte sedimentation rate (ESR)). Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of these biomarkers for CAL.
RESULTS: CAL was present in 30.04% of the children. Pearson correlation analysis revealed that serum PA levels were inversely correlated with WBC count (P = 0.0187), platelet count (P = 0.0116), and ESR (P = 0.0041), while D-dimer levels were positively correlated with these markers (P < 0.001). A negative correlation between PA and D-dimer levels was also observed (P < 0.001). The combined use of PA and D-dimer levels to predict CAL achieved an area under the curve of 0.871.
CONCLUSIONS: Serum PA levels were negatively associated with the severity of KD, whereas D-dimer levels were positively associated. Together, these markers showed significant predictive value for CAL, highlighting their utility in assessing disease severity and guiding management in children with KD.
摘要：
目的：探讨血清纤溶酶原激活物(PA)与D-二聚体的关系。儿童川崎病（KD）的严重程度，以及它们预测冠状动脉病变（CAL）的能力。
方法：本回顾性研究分析了2020年1月至2023年9月在江南大学附属医院确诊的102例KD患儿的临床资料。该队列分为两组：CAL组中31名患有CAL的儿童，非CAL组中71名没有CAL的儿童。该研究评估了CAL的发生率，并调查了血清PA和D-二聚体水平与各种炎症标志物（白细胞（WBC）计数，血小板计数,和红细胞沉降率（ESR））。使用受试者工作特征(ROC)曲线来评估这些生物标志物对CAL的预测值。
结果：CAL存在于30.04％的儿童中。Pearson相关分析显示血清PA水平与白细胞计数呈负相关(P=0.0187)。血小板计数（P=0.0116），和ESR（P=0.0041），而D-二聚体水平与这些标志物呈正相关(P<0.001)。PA和D-二聚体水平也呈负相关(P<0.001)。联合使用PA和D-二聚体水平来预测CAL的曲线下面积为0.871。
结论：血清PA水平与KD的严重程度呈负相关，而D-二聚体水平呈正相关。一起,这些标记对CAL显示出显著的预测价值，强调其在评估KD儿童疾病严重程度和指导管理方面的效用。
方法：本回顾性研究分析了2020年1月至2023年9月在江南大学附属医院确诊的102例KD患儿的临床资料。该队列分为两组：CAL组中31名患有CAL的儿童，非CAL组中71名没有CAL的儿童。该研究评估了CAL的发生率，并调查了血清PA和D-二聚体水平与各种炎症标志物（白细胞（WBC）计数，血小板计数,和红细胞沉降率（ESR））。使用受试者工作特征(ROC)曲线来评估这些生物标志物对CAL的预测值。
结果：CAL存在于30.04％的儿童中。Pearson相关分析显示血清PA水平与白细胞计数呈负相关(P=0.0187)。血小板计数（P=0.0116），和ESR（P=0.0041），而D-二聚体水平与这些标志物呈正相关(P<0.001)。PA和D-二聚体水平也呈负相关(P<0.001)。联合使用PA和D-二聚体水平来预测CAL的曲线下面积为0.871。
结论：血清PA水平与KD的严重程度呈负相关，而D-二聚体水平呈正相关。一起,这些标记对CAL显示出显著的预测价值，强调其在评估KD儿童疾病严重程度和指导管理方面的效用。
