微流体技术已经成为研究动脉血栓形成的强大工具,允许研究人员构建人造血管并复制血流的血液动力学。该技术在理解血栓形成和血小板粘附和聚集方面取得了重大进展。微流体模型具有各种类型和功能,通过研究微流控芯片的制作方法和工作原理,可根据具体需要选择适用的方法。微流控集成系统和模块化微流控系统的快速发展使得动脉血栓研究更加多样化和自动化,但其标准化仍亟待解决。微流体技术的一个关键优势是能够精确控制微通道中的流体流动并分析在不同剪切力和流速下的血小板行为。这使研究人员能够研究血液流动的生理和病理过程,阐明动脉血栓形成的潜在机制。总之,微流控技术通过构建人造血管和准确再现血液动力学,彻底改变了动脉血栓形成的研究。在未来,微流体将更加重视多功能性和自动化,在推进抗血栓治疗和预防措施方面大有希望。
背景是什么?为了研究动脉血栓形成的机制,包括血小板粘附和聚集行为以及凝血过程。微流体技术通常用于研究血栓形成。微流控技术可以在体外微观尺度上模拟真实的生理环境,具有高吞吐量,低成本,和快速的速度。作为一个创新的实验平台,微流控技术已经取得了显著的进步,并在生物和医学领域得到了应用。本文综述了微流体的不同制造方法,并比较了这些方法的优缺点。微流体集成系统和模块化微流体系统的最新发展已导致未来更多样化和自动化的微流体芯片。总结了微流控模型的不同类型和功能。血小板粘附聚集和凝血过程,以及动脉血栓相关的剪切力变化和力学行为,通过构建人工血管和再现血流动力学进行了研究。微流控技术可为制定个性化血栓治疗策略提供依据。通过分析现有药物的作用机制,使用微流控技术进行药物的高通量筛选和药物疗效评估,可以开发更多的药物治疗可能性。有什么影响?这篇综述利用微流体技术进一步推进动脉血栓形成的研究,微流体也有望在未来的生物医学领域发挥更大的作用。
Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of blood flow. This technology has led to significant advancements in understanding thrombosis and platelet adhesion and aggregation. Microfluidic models have various types and functions, and by studying the fabrication methods and working principles of microfluidic chips, applicable methods can be selected according to specific needs. The rapid development of microfluidic integrated system and modular microfluidic system makes arterial thrombosis research more diversified and automated, but its standardization still needs to be solved urgently. One key advantage of microfluidic technology is the ability to precisely control fluid flow in microchannels and to analyze platelet behavior under different shear forces and flow rates. This allows researchers to study the physiological and pathological processes of blood flow, shedding light on the underlying mechanisms of arterial thrombosis. In conclusion, microfluidic technology has revolutionized the study of arterial thrombosis by enabling the construction of artificial blood vessels and accurately reproducing hemodynamics. In the future, microfluidics will place greater emphasis on versatility and automation, holding great promise for advancing antithrombotic therapeutic and prophylactic measures.
What is the context? To study the mechanism of arterial thrombosis, including the platelet adhesion and aggregation behavior and the coagulation process.Microfluidic technology is commonly used to study thrombosis. Microfluidic technology can simulate the real physiological environment on the microscopic scale in vitro, with high throughput, low cost, and fast speed.As an innovative experimental platform, microfluidic technology has made remarkable progress and has found applications in the fields of biology and medicine.What is new? This review summarizes the different fabrication methods of microfluidics and compares the advantages and disadvantages of these methods. Recent developments in microfluidic integrated systems and modular microfluidic systems have led to more diversified and automated microfluidic chips in the future.The different types and functions of microfluidic models are summarized. Platelet adhesion aggregation and coagulation processes, as well as arterial thrombus-related shear force changes and mechanical behaviors, were investigated by constructing artificial blood vessels and reproducing hemodynamics.Microfluidics can provide a basis for the development of personalized thrombosis treatment strategies. By analyzing the mechanism of action of existing drugs, using microfluidic technology for high-throughput screening of drugs and evaluating drug efficacy, more drug therapy possibilities can be developed.What is the impact?This review utilizes microfluidics to further advance the study of arterial thrombosis, and microfluidics is also expected to play a greater role in the biomedical field in the future.