PDF(Pubmed)
Abstract：
Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions and treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) in oxygen transport due to their similar oxygen-carrying capacities. However, applications of HBOCs are hindered by vasoactivity, oxidative toxicity, and a relatively short circulatory half-life. With advancements in nanotechnology, Hb encapsulation, absorption, bioconjugation, entrapment, and attachment to nanomaterials have been used to prepare nanomaterial-related HBOCs to address these challenges and pend their application in several biomedical and therapeutic contexts. This review focuses on the progress of this class of nanomaterial-related HBOCs in the fields of hemorrhagic shock, ischemic stroke, cancer, and wound healing, and speculates on future research directions. The advancements in nanomaterial-related HBOCs are expected to lead significant breakthroughs in blood substitutes, enabling their widespread use in the treatment of clinical diseases.
摘要：
氧气是生命所必需的，在维持正常生理功能和治疗疾病中起着关键的作用。已经研究并开发了基于血红蛋白的氧载体（HBOC），因为它们具有相似的携氧能力，可以替代氧气运输中的红细胞（RBC）。然而,HBOCs的应用受到血管活性的阻碍，氧化毒性，和相对较短的循环半衰期。随着纳米技术的进步，Hb封装，吸收，生物缀合，诱捕,和附着到纳米材料已被用于制备纳米材料相关的HBOCs，以解决这些挑战，并在一些生物医学和治疗环境中的应用。本文就该类纳米材料相关HBOCs在失血性休克领域的研究进展作一综述。缺血性卒中,癌症,伤口愈合，并对未来的研究方向进行了推测。与纳米材料相关的HBOCs的进步有望在血液替代品方面取得重大突破，使其广泛用于临床疾病的治疗。
