目的:研究寻常型痤疮患者眼表疾病和泪液功能的变化,探讨寻常型痤疮与干眼症的潜在关系。
方法:这项横断面研究包括53例寻常痤疮患者和54例健康对照的右眼。参与者完成了眼表疾病指数(OSDI)问卷。测量了以下眼表相关参数:泪液半月板高度(TMH),非侵入性泪液破裂时间(NIBUT),SchirmerI测试(SIT),泪膜的脂质层厚度(LLT)评分,美布得分,睑板腺孔阻塞评分,睑板腺丢失的比率,结膜充血评分,和角膜荧光素染色(CFS)评分。
结果:寻常痤疮患者泪膜稳定性下降。在痤疮组中,TMH和NIBUT较低,而OSDI,美布得分,睑板腺孔阻塞评分,睑板腺丢失的比率,结膜充血评分高于对照组(P<0.05)。CFS评分无显著差异,坐下,或LLT评分组间比较(P>0.05)。在两个干眼症组中,TMH,NIBUT,痤疮干眼症(acne-DE)组LLT评分较低,和Meibum得分,睑板腺孔阻塞评分,痤疮-DE组睑板腺丢失率和结膜充血评分较高(P<0.05)。OSDI之间没有显着差异,坐下,CFS评分(P>0.05)。
结论:患有中度至重度寻常痤疮的患者比没有寻常痤疮的患者更容易出现干眼。在中度至重度痤疮和干眼患者中,泪膜稳定性降低和睑板腺结构功能障碍更为明显。
OBJECTIVE: To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.
METHODS: This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy controls. The participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The following ocular surface-related parameters were measured: tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), Schirmer I test (SIT), lipid layer thickness (LLT) score of the tear film, meibum score, meibomian gland orifice obstruction score, the ratio of meibomian gland loss, conjunctival hyperemia score, and corneal fluorescein staining (CFS) score.
RESULTS: The stability of the tear film decreased in acne vulgaris patients. In the acne group, the TMH and NIBUT were lower, whereas the OSDI, meibum score, meibomian gland orifice obstruction score, ratio of meibomian gland loss, and conjunctival hyperemia score were higher compared with controls (P<0.05). There were no significant differences in the CFS score, SIT, or LLT score between the groups (P>0.05). In two dry eye groups, the TMH, NIBUT, and LLT score were lower in the acne with dry eye (acne-DE) group, and the meibum score, meibomian gland orifice obstruction score, ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher (P<0.05). There were no significant differences between OSDI, SIT, and CFS score (P>0.05).
CONCLUSIONS: Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne vulgaris. Reduced tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.