Abstract：
Acne is a common chronic inflammatory disorder of the sebaceous gland in the hair follicle. Commonly used external medications cause skin irritation, and the transdermal capacity is weak, making it difficult to penetrate the cuticle skin barrier. Hair follicles can aid in the breakdown of this barrier. As nanomaterials progress, polymer-based nanocarriers are routinely used for hair follicle drug delivery to treat acne and other skin issues. Based on the physiological and anatomical characteristics of hair follicles, this paper discusses factors affecting hair follicle delivery by polymer nanocarriers, summarizes the common combination technology to improve the targeting of hair follicles by carriers, and finally reviews the most recent research progress of different polymer nanodrug-delivery systems for the treatment of acne by targeting hair follicles.
摘要：
痤疮是毛囊皮脂腺常见的慢性炎症性疾病。常用的外用药物会引起皮肤刺激，透皮能力较弱，使其难以穿透角质层皮肤屏障。毛囊可以帮助打破这种屏障。随着纳米材料的进步,基于聚合物的纳米载体通常用于毛囊药物递送以治疗痤疮和其他皮肤问题。根据毛囊的生理解剖特征,本文讨论了影响聚合物纳米载体毛囊传递的因素，总结了提高载体对毛囊靶向性的常用组合技术,最后综述了不同聚合物纳米给药系统靶向毛囊治疗痤疮的最新研究进展。
