目的:就影像组学工作流程的不同方面的定义达成共识,以支持其转化为临床应用。此外,评估专家对成功实施临床工作流程的重要挑战的观点。
方法:通过多阶段过程达成共识。第一阶段包括定义筛选,对22个工作流定义中的术语进行语义映射的回顾性分析,以及初始基线定义的编译。第2阶段和第3阶段包括Delphi过程,来自参加德国研究基金会(DFG)优先计划2177的站点的45名专家。第二阶段旨在就定义提案达成广泛共识,而第三阶段确定了翻译挑战的重要性。
结果:分析了22种出版物(2012-2020年出版)的工作流定义。提取了69个定义术语,映射,和语义歧义(例如,同义和同义术语)被识别和解决。共识定义是通过Delphi过程开发的。包括七个阶段和37个方面的最终定义达成了较高的总体共识(>89%的专家“同意”或“强烈同意”)。两个方面没有达成强烈共识。此外,Delphi流程从参与专家的角度确定并描述了影像组学工作流程中的十大最重要挑战。
结论:为了克服现有定义之间的语义不一致,并提供定义良好的,广泛,可引用的术语,我们为基于影像组学的设置编制了一致的工作流程定义,并将术语映射到现有文献.此外,对临床应用最相关的挑战进行了表征.
■缺乏标准化是影像组学成功临床翻译的一个主要障碍。这里,我们报告了关于影像组学研究不同方面的共识工作流程定义,并强调了推进影像组学临床应用的重要挑战.
结论:已发布的放射组学工作流程术语不一致,阻碍标准化和翻译。开发了具有高度一致性的共识放射组学工作流定义提案。供科学界进一步开发的公开成果资源。
OBJECTIVE: Achieving a consensus on a definition for different aspects of radiomics workflows to support their translation into clinical usage. Furthermore, to assess the perspective of experts on important challenges for a successful clinical workflow implementation.
METHODS: The
consensus was achieved by a multi-stage process. Stage 1 comprised a definition screening, a retrospective analysis with semantic mapping of terms found in 22 workflow definitions, and the compilation of an initial baseline definition. Stages 2 and 3 consisted of a Delphi process with over 45 experts hailing from sites participating in the German Research Foundation (DFG) Priority Program 2177. Stage 2 aimed to achieve a broad consensus for a definition proposal, while stage 3 identified the importance of translational challenges.
RESULTS: Workflow definitions from 22 publications (published 2012-2020) were analyzed. Sixty-nine definition terms were extracted, mapped, and semantic ambiguities (e.g., homonymous and synonymous terms) were identified and resolved. The
consensus definition was developed via a Delphi process. The final definition comprising seven phases and 37 aspects reached a high overall consensus (> 89% of experts \"agree\" or \"strongly agree\"). Two aspects reached no strong
consensus. In addition, the Delphi process identified and characterized from the participating experts\' perspective the ten most important challenges in radiomics workflows.
CONCLUSIONS: To overcome semantic inconsistencies between existing definitions and offer a well-defined, broad, referenceable terminology, a consensus workflow definition for radiomics-based setups and a terms mapping to existing literature was compiled. Moreover, the most relevant challenges towards clinical application were characterized.
UNASSIGNED: Lack of standardization represents one major obstacle to successful clinical translation of radiomics. Here, we report a
consensus workflow definition on different aspects of radiomics studies and highlight important challenges to advance the clinical adoption of radiomics.
CONCLUSIONS: Published radiomics workflow terminologies are inconsistent, hindering standardization and translation. A
consensus radiomics
workflow definition proposal with high agreement was developed. Publicly available result resources for further exploitation by the scientific community.