未经评估:为了描述患病率,危险因素,和玻璃体视网膜界面(VRI)异常在一项基于人群的老年人研究中的关联。
未经评估:队列研究参与者的横断面分析。
未经评估:在1149名参与者中(平均年龄,76.1±6.9年)在2007年至2009年的15年蓝山眼科研究随访检查中,905(1791只眼)对至少1只眼的黄斑进行了可分级的时域或谱域OCT扫描。
UASSIGNED:OCT扫描根据VRI异常的国际玻璃体牵引研究组分类系统进行分级。记录最佳矫正视力(BCVA)。
未经批准:VRI的流行率。
未经评估:总的来说,451名参与者显示任何VRI异常(49.8%)。VRI异常的患病率为:玻璃体黄斑粘连(VMA),33.6%;玻璃体黄斑牵引(VMT),1.6%;视网膜前膜(ERM),21.4%;全厚度黄斑裂孔(FTMH),0.7%;和层状黄斑裂孔(LMH),0.7%。22%的VMA是局灶性的,78%是广泛的;76%的VMT是局灶性的,24%是基础广泛的。观察到的所有FTMHs都很大(>400μm),平均孔径为573μm(范围,459-771μm)。年龄增加与较高的ERM和较低的VMA患病率相关(两者均P<0.001)。假性晶状体眼和近视与ERM相关(年龄和性别调整后的比值比[ORs],1.48[95%置信区间(CI),1.01-2.17]和1.72[95%CI,1.05-2.81],分别)。中度或重度ERM和FTMH与9.2个早期治疗糖尿病视网膜病变研究(ETDRS)字母(95%CI,3.4-15.0ETDRS字母;P=0.008)和26.0个ETDRS字母(95%CI,10.9-41.1ETDRS字母;P=0.001)的不良BCVA相关,分别。
未经评估:VRI异常的患病率在老年人中很高。视网膜前膜与年龄增长有关,假晶状体,和近视。视网膜膜和FTMH可能是受影响眼睛的明显视力丧失。这项研究提供了有关老年人VRI异常患病率的有用人群数据。
UNASSIGNED: To describe the prevalence, risk factors, and associations of vitreoretinal interface (VRI) abnormalities in a population-based
study of older adults.
UNASSIGNED: Cross-sectional analysis of cohort
study participants.
UNASSIGNED: Of the 1149 participants (mean age, 76.1 ± 6.9 years) in the 15-year Blue Mountains Eye
Study follow-up examination from 2007 through 2009, 905 (1791 eyes) had gradable time-domain or spectral-domain OCT scans of the macula from at least 1 eye.
UNASSIGNED: OCT scans were graded according to the International Vitreomacular Traction
Study Group classification system of VRI abnormalities. Best-corrected visual acuity (BCVA) was recorded.
UNASSIGNED: Prevalence of VRIs.
UNASSIGNED: Overall, 451 participants showed any VRI abnormality (49.8%). Prevalence of VRI abnormality by person was: vitreomacular adhesion (VMA), 33.6%; vitreomacular traction (VMT), 1.6%; epiretinal membrane (ERM), 21.4%; full-thickness macular hole (FTMH), 0.7%; and lamellar macular hole (LMH), 0.7%. Twenty-two percent of VMAs were focal, and 78% were broad based; 76% of VMTs were focal, and 24% were broad based. All FTMHs observed were large (>400 μm), with mean aperture size of 573 μm (range, 459-771 μm). Increased age was associated with higher ERM and lower VMA prevalence (P < 0.001 for both). Pseudophakia and myopia were associated with ERM (age- and sex-adjusted odds ratios [ORs], 1.48 [95% confidence interval (CI), 1.01-2.17] and 1.72 [95% CI, 1.05-2.81], respectively). Moderate or severe ERM and FTMH were associated with worse BCVA of 9.2 Early Treatment Diabetic Retinopathy
Study (ETDRS) letters (95% CI, 3.4-15.0 ETDRS letters; P = 0.008) and 26.0 ETDRS letters (95% CI, 10.9-41.1 ETDRS letters; P = 0.001), respectively.
UNASSIGNED: The prevalence of VRI abnormalities is high in older individuals. Epiretinal membrane was associated with increasing age, pseudophakia, and myopia. Epiretinal membrane and FTMH may account for significant visual loss in the affected eye. This study provided useful population-based data on the prevalence of VRI abnormalities in older individuals.