关键词： Electroretinogram Ocriplasmin Vitreomacular traction

Mesh ： Acute Disease Blindness / chemically induced diagnosis physiopathology Electroretinography Eye Diseases / drug therapy physiopathology Female Fibrinolysin / adverse effects Fibrinolytic Agents / adverse effects Follow-Up Studies Humans Intravitreal Injections Middle Aged Peptide Fragments / adverse effects Retinal Perforations / drug therapy physiopathology Tomography, Optical Coherence Visual Acuity / drug effects Vitreous Body / drug effects physiopathology

来  源：   DOI：10.1007/s10633-015-9517-7

Abstract：
BACKGROUND: Ocriplasmin is a human plasmin fragment indicated for vitreomacular traction treatment. With its increasing use, several reported cases have suggested possible toxicity to the retina.
METHODS: We describe a case of a 55-year-old woman with symptomatic vitreomacular traction and a macular hole in the right eye who showed an acute decrease in visual acuity after an intravitreal ocriplasmin injection. Spectral-domain optical coherence tomography showed an alteration in the ellipsoid layer. Significant retinal vessel constriction was observed by angiography. The visual acuity improved to 20/100, and the electroretinogram progressively improved after the 1-year follow-up and following pars plana vitrectomy.
CONCLUSIONS: A decrease in visual acuity and an enlargement of the macular hole were observed while studying this patient. This study shows the recovery of adverse effects caused by intravitreal injection of ocriplasmin for 1-year follow-up.
摘要：
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