背景:婴儿血管瘤(IH)是婴儿期最常见的良性肿瘤,但是有关其发病机制的信息有限。这项研究的目的是确定IH的孕产妇和围产期危险因素。
方法:在2017年至2020年期间,共有1033例IH患者被纳入研究。IH患者按性别与对照组相匹配。训练有素的调查人员从参与者那里收集了详细信息。采用Logistic回归模型进行多因素分析。
结果:统计分析表明流产史(比值比[OR]=4.275;95%置信区间[CI][3.195,5.720]),妊娠期贫血(OR=4.228;95%CI[3.083,5.799]),早产胎膜早破(PPROM)(OR=3.182;95%CI[1.359,7.454]),前置胎盘(OR=2.440;95%CI[1.787,3.333]),先兆流产(OR=2.290;95%CI[1.726,3.039]),胎膜早破(PROM)(OR=1.785;P<0.05),孕酮用量(OR=1.614;P<0.001)和羊水量异常(OR=1.499;P<0.05)是IH的独立危险因素。妊娠期糖尿病(GDM)(OR=0.607;95%CI[0.464,0.794]),多胎妊娠(OR=0.407;95%CI[0.232,0.713]),甲状腺功能减退(OR=0.407;95%CI[0.227,0.730])和子宫肌瘤(OR=0.393;95%CI[0.250,0.618])可降低IH的风险。
结论:母婴因素与IH的发生密切相关。我们的研究为指导进一步探索IH的发病机制提供了可靠的线索。
背景:ClinicalTrials.gov,NCT03331744。婴幼儿血管瘤是儿童最常见的良性肿瘤,严重影响外观和功能,甚至威胁生命。发病机制尚不明确,大样本量的孕产妇和围产期的详细病例对照研究将有助于制定个性化和精确的治疗方案,对高危儿童进行早期及时干预,改善预后。我们的研究发现流产史,妊娠期贫血,早产胎膜早破(PPROM),前置胎盘,威胁流产,胎膜早破(PROM),孕酮使用和羊水量异常是IH的独立危险因素。
BACKGROUND: Infantile hemangioma (IH) is the most common benign tumor in infancy, but information about its pathogenesis is limited. The aim of this
study was to determine maternal and perinatal risk factors for IH.
METHODS: A total of 1033 IH patients were enrolled in the
study between 2017 and 2020. IH patients were matched with controls by sex. Trained investigators collected detailed information from the participants. Logistic regression models were used for multivariate analysis.
RESULTS: The statistical analysis demonstrated that miscarriage history (odds ratio [OR] = 4.275; 95% confidence interval [CI] [3.195, 5.720]), anemia in pregnancy (OR = 4.228; 95% CI [3.083, 5.799]), preterm premature rupture of membranes (PPROM) (OR = 3.182; 95% CI [1.359, 7.454]), placenta previa (OR = 2.440; 95% CI [1.787, 3.333]), threatened miscarriage (OR = 2.290; 95% CI [1.726, 3.039]), premature rupture of membranes (PROM) (OR = 1.785; P < 0.05), progesterone use (OR = 1.614; P < 0.001) and abnormal amniotic fluid volume (OR = 1.499; P < 0.05) were independent risk factors for IH. Gestational diabetes mellitus (GDM) (OR = 0.607; 95% CI [0.464, 0.794]), multiple gestations (OR = 0.407; 95% CI [0.232, 0.713]), hypothyroidism (OR = 0.407; 95% CI [0.227, 0.730]) and uterine fibroids (OR = 0.393; 95% CI [0.250, 0.618]) may reduce the risk of IH.
CONCLUSIONS: Maternal and perinatal factors are closely associated with IH occurrence. Our
study provides reliable clues to guide further exploration of the pathogenesis of IH.
BACKGROUND: ClinicalTrials.gov, NCT03331744. Infantile hemangioma is the most common benign tumor in children, which seriously affects appearance and function and even threatens life. The pathogenesis is not clear, a detailed case-control
study of the maternal and perinatal periods with a large sample size will facilitate the development of individualized and precise treatment, early and timely interventions for high-risk children and improvement of prognosis. Our
study found that miscarriage history, anemia in pregnancy, preterm premature rupture of membranes (PPROM), placenta previa, threatened miscarriage, premature rupture of membranes (PROM), progesterone use and abnormal amniotic fluid volume were independent risk factors for IH.