PDF(Pubmed)
Abstract：
UNASSIGNED: Systemic lupus erythematosus (SLE) is an autoimmune disease caused by genetic and environmental factors such as viral infections. Genomic and serologic tests were applied to detect significant blood-borne viruses in SLE patients to determine whether there was a possible association between viral infections and SLE.
UNASSIGNED: Antibodies (Abs) against HHV-8, HCMV, EBV, HIV, HBV, and HCV in SLE patients suffering from SLE were assessed by ELISA. In addition, HHV-8 DNA and HIV-1 RNA were quantified by real-time PCR, and the HCV and HBV genomes were detected using nested PCR.
UNASSIGNED: Compared to those in the control group, a high prevalence of anti-HHV-8 (p < 0.0001), anti-HCMV (p = 0.014), and anti-EBV (p = 0.017) Abs was detected in SLE patients. HHV-8, HIV, HCV, and HBV genomic tests were negative in both groups, while only 1.1 %, 2.2 %, and 1.1 % of SLE patients were positive for anti-HIV, anti-HCV Abs, and HBsAg, respectively. The most frequent major complaint in patients was arthralgia (76.7 %).
UNASSIGNED: The increased prevalence of anti-HHV-8 Abs may not be related to the natural history of infection but to molecular mimicry. Increased anti-HCMV and anti-EBV Abs may also be associated with the development of SLE and may play direct or indirect roles in such infections or molecular mimicry. Since arthralgia is the most common symptom in SLE patients, the presence of these symptoms in any patient is a suggestive clue for the diagnosis of SLE. Defining the typical pattern of SLE in divergent nations with distinct environmental and geographical factors can be beneficial for obtaining a prompt diagnosis.
UNASSIGNED: Antibodies (Abs) against HHV-8, HCMV, EBV, HIV, HBV, and HCV in SLE patients suffering from SLE were assessed by ELISA. In addition, HHV-8 DNA and HIV-1 RNA were quantified by real-time PCR, and the HCV and HBV genomes were detected using nested PCR.
UNASSIGNED: Compared to those in the control group, a high prevalence of anti-HHV-8 (p < 0.0001), anti-HCMV (p = 0.014), and anti-EBV (p = 0.017) Abs was detected in SLE patients. HHV-8, HIV, HCV, and HBV genomic tests were negative in both groups, while only 1.1 %, 2.2 %, and 1.1 % of SLE patients were positive for anti-HIV, anti-HCV Abs, and HBsAg, respectively. The most frequent major complaint in patients was arthralgia (76.7 %).
UNASSIGNED: The increased prevalence of anti-HHV-8 Abs may not be related to the natural history of infection but to molecular mimicry. Increased anti-HCMV and anti-EBV Abs may also be associated with the development of SLE and may play direct or indirect roles in such infections or molecular mimicry. Since arthralgia is the most common symptom in SLE patients, the presence of these symptoms in any patient is a suggestive clue for the diagnosis of SLE. Defining the typical pattern of SLE in divergent nations with distinct environmental and geographical factors can be beneficial for obtaining a prompt diagnosis.
摘要：
■系统性红斑狼疮（SLE）是由遗传和环境因素如病毒感染引起的自身免疫性疾病。应用基因组和血清学测试来检测SLE患者中重要的血液传播病毒，以确定病毒感染与SLE之间是否存在可能的关联。
■抗HHV-8、HCMV、EBV,艾滋病毒,HBV,通过ELISA评估患有SLE的SLE患者的HCV。此外,通过实时PCR定量HHV-8DNA和HIV-1RNA,使用巢式PCR检测HCV和HBV基因组。
■与对照组相比，抗HHV-8的高患病率（p<0.0001），抗HCMV（p=0.014），在SLE患者中检测到抗EBV（p=0.017）Abs。HHV-8HIV,HCV,和HBV基因组测试是阴性的两组，虽然只有1.1%，2.2%,1.1%的SLE患者抗HIV阳性，抗HCVAb，和HBsAg，分别。患者最常见的主要主诉是关节痛（76.7％）。
■抗HHV-8Ab的患病率增加可能与感染的自然史无关，而是与分子模仿有关。增加的抗HCMV和抗EBVAb也可能与SLE的发展有关，并且可能在此类感染或分子模仿中起直接或间接作用。由于关节痛是SLE患者最常见的症状，任何患者出现这些症状都是诊断SLE的提示线索.在具有不同环境和地理因素的不同国家中定义SLE的典型模式可能有助于获得及时诊断。
■抗HHV-8、HCMV、EBV,艾滋病毒,HBV,通过ELISA评估患有SLE的SLE患者的HCV。此外,通过实时PCR定量HHV-8DNA和HIV-1RNA,使用巢式PCR检测HCV和HBV基因组。
■与对照组相比，抗HHV-8的高患病率（p<0.0001），抗HCMV（p=0.014），在SLE患者中检测到抗EBV（p=0.017）Abs。HHV-8HIV,HCV,和HBV基因组测试是阴性的两组，虽然只有1.1%，2.2%,1.1%的SLE患者抗HIV阳性，抗HCVAb，和HBsAg，分别。患者最常见的主要主诉是关节痛（76.7％）。
■抗HHV-8Ab的患病率增加可能与感染的自然史无关，而是与分子模仿有关。增加的抗HCMV和抗EBVAb也可能与SLE的发展有关，并且可能在此类感染或分子模仿中起直接或间接作用。由于关节痛是SLE患者最常见的症状，任何患者出现这些症状都是诊断SLE的提示线索.在具有不同环境和地理因素的不同国家中定义SLE的典型模式可能有助于获得及时诊断。
