PDF(Pubmed)
Abstract：
BACKGROUND: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition affecting multiple systems. Cardiovascular morbidity is a significant concern, with around 25% of SLE patients experiencing cardiac complications.
OBJECTIVE: This study aims to determine the prevalence of cardiovascular morbidity in SLE patients in King Fahad Medical City (KFMC) in Riyadh, Saudi Arabia.
METHODS: This retrospective record-based research was conducted at KFMC from January 2015 to October 2023. A review of the medical files of all SLE patients was accomplished.
RESULTS: The vast majority of the patients (90.9%) were females. The mean age for the patients was 36.5 years. The most common comorbidities were lupus nephritis (34.6%), hypothyroidism (18.4%), and anti-phospholipid syndrome (9.2%). The most commonly used medications were hydroxychloroquine (81.8%), corticosteroids (prednisolone) (43.0%), and mycophenolate mofetil (27.9%). Around 45.2% (n= 176) of the patients with SLE developed cardiovascular complications. The most commonly reported cardiovascular diseases that developed after diagnosing patients with SLE were hypertension (22.4%), valvular heart diseases (13.2%), and dyslipidemia (9.2%). The study also found that anti-dsDNA antibodies can reduce the likelihood of developing hypertension by 40%. This research contributes to the medical literature on SLE and sets the stage for future research on personalized healthcare strategies for managing SLE and its complications.
CONCLUSIONS: This study highlights that a considerable proportion of SLE patients(~50%) develop cardiovascular complications, with hypertension, valvular heart diseases, and dyslipidemia being the most common. We also discovered that anti-double-stranded deoxyribonucleic acid antibodies (Anti-dsDNA) reduce the likelihood of developing hypertension.
OBJECTIVE: This study aims to determine the prevalence of cardiovascular morbidity in SLE patients in King Fahad Medical City (KFMC) in Riyadh, Saudi Arabia.
METHODS: This retrospective record-based research was conducted at KFMC from January 2015 to October 2023. A review of the medical files of all SLE patients was accomplished.
RESULTS: The vast majority of the patients (90.9%) were females. The mean age for the patients was 36.5 years. The most common comorbidities were lupus nephritis (34.6%), hypothyroidism (18.4%), and anti-phospholipid syndrome (9.2%). The most commonly used medications were hydroxychloroquine (81.8%), corticosteroids (prednisolone) (43.0%), and mycophenolate mofetil (27.9%). Around 45.2% (n= 176) of the patients with SLE developed cardiovascular complications. The most commonly reported cardiovascular diseases that developed after diagnosing patients with SLE were hypertension (22.4%), valvular heart diseases (13.2%), and dyslipidemia (9.2%). The study also found that anti-dsDNA antibodies can reduce the likelihood of developing hypertension by 40%. This research contributes to the medical literature on SLE and sets the stage for future research on personalized healthcare strategies for managing SLE and its complications.
CONCLUSIONS: This study highlights that a considerable proportion of SLE patients(~50%) develop cardiovascular complications, with hypertension, valvular heart diseases, and dyslipidemia being the most common. We also discovered that anti-double-stranded deoxyribonucleic acid antibodies (Anti-dsDNA) reduce the likelihood of developing hypertension.
摘要：
背景：系统性红斑狼疮（SLE）是一种影响多个系统的自身免疫性炎症。心血管发病率是一个重要的问题，约25%的SLE患者出现心脏并发症。
目的：本研究旨在确定利雅得法哈德国王医疗城（KFMC）SLE患者的心血管疾病患病率，沙特阿拉伯。
方法：这项基于记录的回顾性研究于2015年1月至2023年10月在KFMC进行。完成了对所有SLE患者的医疗档案的审查。
结果：绝大多数患者（90.9%）为女性。患者的平均年龄为36.5岁。最常见的合并症是狼疮性肾炎(34.6%),甲状腺功能减退（18.4%），和抗磷脂综合征(9.2%)。最常用的药物是羟氯喹（81.8%），皮质类固醇（泼尼松龙）（43.0%），和霉酚酸酯（27.9%）。约45.2％（n=176）的SLE患者发生心血管并发症。诊断为SLE患者后最常见的心血管疾病是高血压（22.4%）。心脏瓣膜病（13.2%），和血脂异常(9.2%)。该研究还发现，抗dsDNA抗体可以将患高血压的可能性降低40％。这项研究有助于SLE的医学文献，并为未来研究SLE及其并发症的个性化医疗保健策略奠定了基础。
结论：这项研究强调，相当比例的SLE患者（约50％）发生心血管并发症，患有高血压，心脏瓣膜病,和血脂异常是最常见的。我们还发现抗双链脱氧核糖核酸抗体(Anti-dsDNA)降低了发生高血压的可能性。
目的：本研究旨在确定利雅得法哈德国王医疗城（KFMC）SLE患者的心血管疾病患病率，沙特阿拉伯。
方法：这项基于记录的回顾性研究于2015年1月至2023年10月在KFMC进行。完成了对所有SLE患者的医疗档案的审查。
结果：绝大多数患者（90.9%）为女性。患者的平均年龄为36.5岁。最常见的合并症是狼疮性肾炎(34.6%),甲状腺功能减退（18.4%），和抗磷脂综合征(9.2%)。最常用的药物是羟氯喹（81.8%），皮质类固醇（泼尼松龙）（43.0%），和霉酚酸酯（27.9%）。约45.2％（n=176）的SLE患者发生心血管并发症。诊断为SLE患者后最常见的心血管疾病是高血压（22.4%）。心脏瓣膜病（13.2%），和血脂异常(9.2%)。该研究还发现，抗dsDNA抗体可以将患高血压的可能性降低40％。这项研究有助于SLE的医学文献，并为未来研究SLE及其并发症的个性化医疗保健策略奠定了基础。
结论：这项研究强调，相当比例的SLE患者（约50％）发生心血管并发症，患有高血压，心脏瓣膜病,和血脂异常是最常见的。我们还发现抗双链脱氧核糖核酸抗体(Anti-dsDNA)降低了发生高血压的可能性。
