respiratory symptoms

呼吸道症状
  • 文章类型: Journal Article
    背景:我们进行了范围审查,以概述急诊医学中即时护理肺超声(LUS)的证据。通过强调临床主题,时间趋势,研究设计,以及主要结果的范围,我们为医生和研究人员提供地图,以指导他们未来的计划。
    目的:已发表的LUS在急诊医学研究中报告了哪些研究设计和主要结局?
    方法:我们在PubMed/MEDLINE进行了系统搜索,EMBASE,WebofScience,Scopus,和2023年5月13日之前发表的LUS研究的Cochrane图书馆数据库。定量合成了研究特征。所有论文中的主要结果都分为Fryback和Thornbury级别。
    结果:共筛选了4,076篇论文,在选择和手工搜索之后,包括406篇论文。从2020年1月到2023年5月,出版物数量翻了一番(204至406篇论文)。研究设计主要是观察性的(375,92%),其次是随机(18,4%)和病例系列(13,3%)。主要结果指标涉及319篇论文(79%)的诊断准确性,32例(8%)的诊断思维,治疗性变化4(1%),和患者的结果在14(3%)。随着时间的推移,没有观察到随机对照试验的比例或主要结局指标的范围增加。创建了一个免费的交互式数据库,使读者能够搜索任何给定的兴趣(https://public。tableau.com/app/profile/blinded/viz/LUSinEM_240216/INFO)。
    结论:已经进行了大量的观察性诊断研究,探索临床效用的研究很少。值得注意的是,在对患者获益进行进一步研究之前,探索LUS是否会导致临床决策发生变化的研究势在必行.
    BACKGROUND: This scoping review was conducted to provide an overview of the evidence of point-of-care lung ultrasound (LUS) in emergency medicine. By emphasizing clinical topics, time trends, study designs, and the scope of the primary outcomes, a map is provided for physicians and researchers to guide their future initiatives.
    OBJECTIVE: Which study designs and primary outcomes are reported in published studies of LUS in emergency medicine?
    METHODS: We performed a systematic search in the PubMed/MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library databases for LUS studies published prior to May 13, 2023. Study characteristics were synthesized quantitatively. The primary outcomes in all papers were categorized into the hierarchical Fryback and Thornbury levels.
    RESULTS: A total of 4,076 papers were screened and, following selection and handsearching, 406 papers were included. The number of publications doubled from January 2020 to May 2023 (204 to 406 papers). The study designs were primarily observational (n = 375 [92%]), followed by randomized (n = 18 [4%]) and case series (n = 13 [3%]). The primary outcome measure concerned diagnostic accuracy in 319 papers (79%), diagnostic thinking in 32 (8%), therapeutic changes in 4 (1%), and patient outcomes in 14 (3%). No increase in the proportions of randomized controlled trials or the scope of primary outcome measures was observed with time. A freely available interactive database was created to enable readers to search for any given interest (https://public.tableau.com/app/profile/blinded/viz/LUSinEM_240216/INFO).
    CONCLUSIONS: Observational diagnostic studies have been produced in abundance, leaving a paucity of research exploring clinical utility. Notably, research exploring whether LUS causes changes to clinical decisions is imperative prior to any further research being made into patient benefits.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Systematic Review
    呼吸系统疾病是一个巨大的全球负担,需要有效的诊断方法进行及时干预。基于音频的数字生物标志物,声学,和上下呼吸系统发出的声音,以及声音,已成为呼吸功能的有价值指标。机器学习(ML)算法的最新进展为通过分析和处理此类基于音频的生物标志物来识别和诊断呼吸系统疾病提供了有希望的途径。越来越多的研究采用ML技术从音频生物标志物中提取有意义的信息。除了疾病识别,这些研究探索了不同的方面,例如在环境噪声中识别咳嗽声音,分析呼吸音,以检测呼吸道症状,如喘息和裂纹,以及语音/语音的分析,用于评估人类语音异常。为了提供更深入的分析,这篇综述审查了75项相关的音频分析研究,涉及三个不同的领域,涉及呼吸道疾病的症状:(a)咳嗽检测,(b)下呼吸道症状识别,和(c)来自语音和语音的诊断。此外,提供了该领域常用的公共可用数据集。据观察,研究趋势受到大流行的影响,随着对COVID-19诊断的研究激增,移动数据采集,和远程诊断系统。
    Respiratory diseases represent a significant global burden, necessitating efficient diagnostic methods for timely intervention. Digital biomarkers based on audio, acoustics, and sound from the upper and lower respiratory system, as well as the voice, have emerged as valuable indicators of respiratory functionality. Recent advancements in machine learning (ML) algorithms offer promising avenues for the identification and diagnosis of respiratory diseases through the analysis and processing of such audio-based biomarkers. An ever-increasing number of studies employ ML techniques to extract meaningful information from audio biomarkers. Beyond disease identification, these studies explore diverse aspects such as the recognition of cough sounds amidst environmental noise, the analysis of respiratory sounds to detect respiratory symptoms like wheezes and crackles, as well as the analysis of the voice/speech for the evaluation of human voice abnormalities. To provide a more in-depth analysis, this review examines 75 relevant audio analysis studies across three distinct areas of concern based on respiratory diseases\' symptoms: (a) cough detection, (b) lower respiratory symptoms identification, and (c) diagnostics from the voice and speech. Furthermore, publicly available datasets commonly utilized in this domain are presented. It is observed that research trends are influenced by the pandemic, with a surge in studies on COVID-19 diagnosis, mobile data acquisition, and remote diagnosis systems.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    血吸虫病在全球范围内贡献了250万残疾调整生命年。曼氏血吸虫的急性和慢性呼吸道发病率(S.mansoni)在文献中的记载很少。我们对曼氏链球菌患者的呼吸道症状和肺功能异常的负担进行了快速文献综述。我们还报告了所审查研究的免疫学和肺部影像学发现。
    从数据库建立到2023年3月13日,我们在Embase和MEDLINE中进行了全面的文献检索。
    从24例病例报告中,共报告了2243例曼氏球菌患者,11个横断面研究,7个案例系列,2项队列研究和2项随机对照试验。任何呼吸道症状的患病率为13.3-63.3%(研究的患者总数,n=149)。在寻求呼吸道症状的曼氏链球菌患者中,个体症状的患病率如下:咳嗽(8.3-80.6%,n=338),呼吸困难(1.7-100.0%,n=200),胸痛(9.0-57.1%,n=86),痰液产量(20.0-23.3%,n=30)和喘息(0.0-20.0%,n=1396)。急性血吸虫病的症状频率往往较高。限制性肺病患病率为29.0%(9/31)。报告的最常见的胸部影像学发现是结节(20-90%,n=103)和间质渗透(12.5-23.0%,n=89)。72.0-100.0%的急性血吸虫病患者(n=130)普遍存在外周血嗜酸性粒细胞增多,并与症状和影像学异常有关。3例慢性曼氏链球菌报告C反应蛋白升高,白细胞,中性粒细胞和绝对嗜酸性粒细胞计数,嗜酸性粒细胞百分比,IgE和IgG4。
    曼氏链球菌患者的呼吸系统发病率很高,特别是在感染的急性期,虽然研究相对较小。需要更大规模的研究来描述慢性血吸虫病的呼吸道发病率,并确定潜在的临床和免疫机制。
    BilharziaBilharzia患者的呼吸系统问题会导致受影响者的严重健康问题。然而,对与bilharzia相关的呼吸问题知之甚少。我们系统地搜索了文献中有关bilharzia和呼吸问题的研究。我们发现很高比例的bilharzia患者报告咳嗽,呼吸困难,胸痛,痰和喘息。此外,相当数量的患者有肺功能受损和X线成像异常.血液嗜酸性粒细胞倾向于与呼吸道症状和影像学异常有关,这表明嗜酸性粒细胞可能与引起呼吸道问题有关。我们得出的结论是,尽管所审查的研究规模很小,而且主要是在急性感染人群中,但肺部问题在bilharzia患者中很常见。需要更大规模的研究来进一步描述Bilharzia的肺部问题。
    UNASSIGNED: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of Schistosoma mansoni (S. mansoni) is poorly documented in the literature. We conducted a rapid literature review of the burden of respiratory symptoms and lung function abnormalities among patients with S. mansoni. We also report the immunologic and lung imaging findings from the studies reviewed.
    UNASSIGNED: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023.
    UNASSIGNED: A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3-63.3% (total number of patients studied, n = 149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3-80.6%, n = 338), dyspnea (1.7-100.0%, n = 200), chest pain (9.0-57.1%, n = 86), sputum production (20.0-23.3%, n = 30) and wheezing (0.0 - 20.0%, n = 1396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9/31). The commonest chest imaging findings reported were nodules (20-90%, n = 103) and interstitial infiltrates (12.5-23.0%, n = 89). Peripheral blood eosinophilia was prevalent in 72.0-100.0% of patients (n = 130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4.
    UNASSIGNED: There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.
    Respiratory problems in people with bilharzia Bilharzia causes significant health problems among those affected. However, little is known about respiratory problems associated with bilharzia. We systematically searched for studies published on bilharzia and respiratory problems in literature. We found that a high proportion of people with bilharzia report cough, difficulty in breathing, chest pain, sputum production and wheezing. Also, a good number have lung function impairment and abnormalities on X-ray imaging. Blood eosinophils tended to be associated with the respiratory symptoms and imaging abnormalities which suggests that eosinophils may be involved in causing respiratory problems. We conclude that lung problems are common among people with bilharzia although the studies reviewed were small and mostly among people with acute infection. Larger studies are needed to further characterise lung problems in Bilharzia.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:电子烟(电子烟)的使用在成年人中越来越受欢迎。监测电子烟引起的呼吸道症状对于临床和监管目的都至关重要。我们系统地回顾了当前的文献,以了解独家电子烟使用者中呼吸道症状的患病率,双用户,以前的吸烟者。
    方法:搜索的数据库包括PubMed、CINAHL,科克伦图书馆,Embase,还有Scopus.我们包括所有的英语,探索电子烟相关呼吸道症状患病率的实证定量文章。随机效应模型用于进行荟萃分析。使用NIH研究质量评估工具评估已确定研究的质量。本研究在PROSPERO(#CRD42020165973)注册。
    结果:文献检索确定了1240篇参考文献。删除重复项并筛选资格后,最终审查中纳入了168项研究。大多数纳入的研究报告了广泛的不良呼吸道症状。呼吸道症状在独家电子烟使用者中普遍存在,双用户,以及那些从可燃香烟转向电子香烟的人。Further,在RCT研究中,5被评为质量好,而3人被评为公平。在观察性研究中,24被评为质量好,9人被评为公平。两项实验研究均被评为质量一般。
    结论:继续监测电子烟使用者的呼吸道症状是必要的。由于研究之间的异质性和不一致性,这限制了结果的解释,并强调了评估因果推断的研究的必要性,使用稳健的研究设计进行进一步的研究是必不可少的。这将为临床医生提供有关使用电子烟的潜在呼吸风险的全面知识。
    BACKGROUND: Electronic cigarette (e-cigarette) use is gaining popularity among adults. Monitoring e-cigarette-induced respiratory symptoms is crucial for both clinical and regulatory purposes. We systematically reviewed the current literature to understand the prevalence of respiratory symptoms among exclusive e-cigarette users, dual users, and former smokers.
    METHODS: Databases searched included PubMed, CINAHL, Cochrane Library, Embase, and Scopus. We included all English-language, empirical quantitative articles that explored the prevalence of e-cigarette-related respiratory symptoms. Random-effects models were utilized in conducting the meta-analyses. The quality of identified studies was evaluated using the NIH Study Quality Assessment Tools. This study is registered with PROSPERO(#CRD42020165973).
    RESULTS: The literature search identified 1240 references. After removing duplicates and screening for eligibility, 168 studies were included in the final review. The majority of included studies reported a wide range of adverse respiratory symptoms. The respiratory symptoms were prevalent among the exclusive e-cigarette users, dual users, and those who switched from combustible cigarettes to e-cigarettes. Further, out of the RCT studies, 5 were rated as good quality, while 3 were rated as fair. Among the observational studies, 24 were rated as good quality, and 9 were rated as fair. The two experimental studies were both rated as fair quality.
    CONCLUSIONS: Continued monitoring of respiratory symptoms among e-cigarette users is warranted. Due to the heterogeneity and inconsistencies among studies, which limit result interpretation and highlight the need for studies assessing causal inference, further research using robust study designs is essential. This will provide clinicians with comprehensive knowledge about the potential respiratory risks of e-cigarette use.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Systematic Review
    越来越多的证据表明,儿童也可以发展长型Covid。然而,没有明确的评论对报告的呼吸道症状和潜在诊断进行了描述.
    我们在Pubmed上进行了一项对18岁以下儿童进行的研究,这些儿童以前患有SARS-CoV-2感染,抱怨持续的呼吸道症状;我们审查的目的是表征发病率,儿科人群急性感染后呼吸道症状的模式和持续时间。
    儿童会出现持续的呼吸道症状,正如几项随访研究所记录的那样,包括或不包括未感染儿童的对照组。然而,所分析研究的方法学差异不允许提供关于该比率的确切结论,持续呼吸道症状儿童的类型和最佳诊断。未来的研究应该在更大的儿科队列中研究非侵入性诊断和新的生物标志物的作用,以及在急性感染期间或确诊LongCovid时研究治疗选择。
    There is increasing evidence that also children can develop Long Covid. However, there are no specific reviews providing a clear description of reported respiratory symptoms and potential diagnostics.
    We performed on PubMed a systematic search of studies conducted on children aged less than 18 years with previous SARS-CoV-2 infection complaining about persistent respiratory symptoms; the aim of our review is to characterize the incidence, pattern and duration of respiratory symptoms after the acute infection in pediatric population.
    Children can develop persisting respiratory symptoms, as documented by several follow-up studies both including or not control groups of non-infected children. However, the methodological variabilities of the analyzed studies does not allow to provide firm conclusions about the rate, type and best diagnostics for children with persistent respiratory symptoms. Future studies should investigate on larger pediatric cohorts the role of noninvasive diagnostics and new biomarkers as well as investigating therapeutic options both during acute infection or when Long Covid has been diagnosed.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    来自不同来源的环境大气中生物气溶胶的排放是人类健康和环境的关注原因。生物气溶胶是微生物和花粉等生物物质的组合。本综述强调对各种生物气溶胶来源的理解(工业,城市固体废物,和医疗设施),他们的组件,以及它们对人类健康的影响。生物气溶胶的研究是非常重要的,因为估计大量的人在全球范围内暴露。在不同的工作环境中暴露生物气溶胶会导致健康问题,例如传染病,过敏,毒性作用,和呼吸问题。因此,敦促进行广泛的研究,以建立对工作场所生物气溶胶暴露的有效评估,涉及的风险,分布,和验证。本综述旨在探讨生物气溶胶在大气中的暴露及其对人类健康的影响之间的关系。一些初步发现,根据我们对垃圾填埋场和海德拉巴废物转运站的城市固体废物产生的生物气溶胶的分析,印度,这里也讨论了。
    The emission of bioaerosols in the ambient atmosphere from different sources is a cause of concern for human health and the environment. Bioaerosols are a combination of biotic matter like microbes and pollens. The present review emphasizes the understanding of various sources of bioaerosols (industries, municipal solid waste, and medical facilities), their components, and their impact on human health. The study of bioaerosols is of great importance as large numbers of people are estimated to be exposed on the global scale. Bioaerosols exposure in different work environments results in health issues such as infectious diseases, allergies, toxic effects, and respiratory problems. Hence, extensive research is urged to establish an effective assessment of bioaerosols exposure in the workplace, risks involved, distribution, and validation. The present review is intended to explore the relationship between bioaerosols exposure to the atmosphere and its impacts on human health. Some of the preliminary findings, based on our analysis of bioaerosols arising from municipal solid waste at a landfill site and a waste transfer station in Hyderabad, India, are also discussed herein.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    UNASSIGNED: Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti-inflammatory effects.
    UNASSIGNED: The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non-English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included.
    UNASSIGNED: Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications.
    UNASSIGNED: Consequently, the findings of the current review demonstrate that Curcumin\'s modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    UNASSIGNED:来自多个工作场所的多项研究报告,暴露于清洁或消毒剂的工人中哮喘和哮喘样呼吸道症状增加。医院工作人员进行许多清洁和消毒活动,并且可能容易受到这些药物引起的呼吸道和皮肤症状的影响。这项系统评价和荟萃分析旨在量化暴露于清洁/消毒剂的医院工作人员患哮喘和哮喘样症状的风险。次要目的是评估这些研究中皮肤症状的相关风险。
    未经批准:MEDLINE,EMBASE,CDSR,中部,CINAHL数据库,并检索了相关评论文章的参考文献。NHLBI质量评估工具用于评估纳入研究的质量。共检索到2550篇文章,34项研究符合纳入标准。使用软件R版本4.0.5进行荟萃分析。由于研究内异质性,随机效应模型用于汇集结果。
    UNASSIGNED:10项评估职业清洁暴露与哮喘之间关联的研究的荟萃分析显示,暴露的医院工作人员的风险增加了35%(meta-RR=1.35,95%CI:1.09-1.68)。与未接触工人相比,暴露于漂白剂的工人患哮喘的风险增加(meta-RR=1.51,95%CI:0.54-4.18),但没有统计学意义。两项研究调查了呼吸道和皮肤症状之间的关系,并产生了混合的结果。
    UNASSIGNED:结果表明,需要采取预防措施,以降低暴露于职业清洁/消毒剂的医院工作人员患哮喘和哮喘样症状的风险。试用注册号:CRD42020137804。
    UNASSIGNED: Several studies from multiple work settings have reported an increase in asthma and asthma-like respiratory symptoms in workers exposed to cleaning or disinfecting agents. Hospital workers perform many cleaning and disinfecting activities and may be vulnerable to respiratory and skin symptoms caused by these agents. This systematic review and meta-analysis aim to quantify the risk of asthma and asthma-like symptoms in hospital workers exposed to cleaning/disinfecting agents. A secondary aim is to assess associated risks of skin symptoms in those studies.
    UNASSIGNED: MEDLINE, EMBASE, CDSR, CENTRAL, CINAHL databases, and references of relevant review articles were searched. NHLBI quality assessment tools were used to assess the quality of the included studies. A total of 2550 articles were retrieved and 34 studies met criteria to be included. The software R version 4.0.5 was used to perform the meta-analysis. The random-effects model was used to pool the results due to within-studies heterogeneity.
    UNASSIGNED: Meta-analysis of 10 studies evaluating the association between occupational cleaning exposures and asthma demonstrated a 35% increased risk in exposed hospital workers (meta-RR = 1.35, 95% CI: 1.09-1.68). The risk of asthma increased when workers were exposed to bleach compared with nonexposed workers (meta-RR = 1.51, 95% CI: 0.54-4.18), but was not statistically significant. Two studies investigated the relationship between respiratory and skin symptoms and produced mixed results.
    UNASSIGNED: The results suggest a need for preventive practices to reduce the risk of asthma and asthma-like symptoms in hospital workers exposed to occupational cleaning/disinfecting agents. Trial registration number: CRD42020137804.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    哮喘和慢性阻塞性肺疾病(COPD)是非常普遍的慢性肺部疾病,需要持续的自我管理,本身往往是次优的。因此,远程监测已被用来帮助患者测量他们的症状,与医疗保健提供商共享数据,并接受教育和反馈,以改善疾病管理。在这项研究中,我们对有关成人哮喘和COPD远程监测有效性的最新证据进行了叙述性综述.在13项确定的研究中,11个关注COPD,2个关注哮喘。审查了所有研究,比较干预组和照常护理组的效果。在研究干预中,七个在至少一个结果指标上显示出积极的结果,其中6项在任何一项结果衡量标准上都没有显著结果。所有取得积极成果的干预措施都包括教育部分,而没有积极结果的六项干预措施中只有一项包括教育部分。我们得出的结论是,如果对哮喘和COPD的远程监测干预措施包括有关自我管理的不同方面的教育内容,则它们似乎更有效。
    Asthma and chronic obstructive pulmonary diseases (COPD) are highly prevalent chronic lung diseases that require ongoing self-management, which itself is often suboptimal. Therefore, telemonitoring has been used to help patients measure their symptoms, share data with healthcare providers and receive education and feedback to improve disease management. In this study, we conducted a narrative review of recent evidence on the effectiveness of telemonitoring for asthma and COPD in adults. Of the thirteen identified studies, eleven focused on COPD and two focused on asthma. All studies were reviewed, and effects were compared between intervention and care as usual groups. Of the study interventions, seven showed a positive outcome on at least one outcome measure, and six had no significant results on any of the outcome measures. All of the interventions with a positive outcome included an educational component, while only one of the six interventions without positive outcomes included an educational component. We conclude that telemonitoring interventions for asthma and COPD seem more effective if they included an educational component regarding different aspects of self-management.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    BACKGROUND: The long-term impact of COVID-19 is still unknown. This study aimed to explore post COVID-19 effects on patients chest computed tomography (CT), lung function, respiratory symptoms, fatigue, functional capacity, health-related quality of life (HRQoL), and the ability to return to work beyond 3 months post infection.
    METHODS: A systematic search was performed on PubMed, Web of Science, and Ovid MEDLINE on 22 May 2021, to identify studies that reported persistent effects of COVID-19 beyond 3 months follow-up. Data on the proportion of patients who had the outcome were collected and analyzed using a one-group meta-analysis.
    RESULTS: Data were extracted from 24 articles that presented information on a total of 5323 adults, post-infection, between 3 to 6 months after symptom onset or hospital discharge. The pooled prevalence of CT abnormalities was 59% (95% CI 44-73, I2 = 96%), abnormal lung function was 39% (95% CI 24-55, I2 = 94%), fatigue was 38% (95% CI 27-49, I2 = 98%), dyspnea was 32% (95% CI 24-40, I2 = 98%), chest paint/tightness was 16% (95% CI 12-21, I2 = 94%), and cough was 13%, (95% CI 9-17, I2 = 94%). Decreased functional capacity and HRQoL were found in 36% (95% CI 22-49, I2 = 97%) and 52% (95% CI 33-71, I2 = 94%), respectively. On average, 8 out of 10 of the patients had returned to work or reported no work impairment.
    CONCLUSIONS: Post-COVID-19 patients may experience persistent respiratory symptoms, fatigue, decreased functional capacity and decreased quality of life up to 6 months after infection. Further studies are needed to establish the extent to which post-COVID-19 effects continue beyond 6 months, how they interact with each other, and to clarify their causes and their effective management.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Sci-hub)

       PDF(Pubmed)

公众号