PDF(Pubmed)
Abstract：
UNASSIGNED: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of Schistosoma mansoni (S. mansoni) is poorly documented in the literature. We conducted a rapid literature review of the burden of respiratory symptoms and lung function abnormalities among patients with S. mansoni. We also report the immunologic and lung imaging findings from the studies reviewed.
UNASSIGNED: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023.
UNASSIGNED: A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3-63.3% (total number of patients studied, n = 149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3-80.6%, n = 338), dyspnea (1.7-100.0%, n = 200), chest pain (9.0-57.1%, n = 86), sputum production (20.0-23.3%, n = 30) and wheezing (0.0 - 20.0%, n = 1396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9/31). The commonest chest imaging findings reported were nodules (20-90%, n = 103) and interstitial infiltrates (12.5-23.0%, n = 89). Peripheral blood eosinophilia was prevalent in 72.0-100.0% of patients (n = 130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4.
UNASSIGNED: There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.
Respiratory problems in people with bilharzia Bilharzia causes significant health problems among those affected. However, little is known about respiratory problems associated with bilharzia. We systematically searched for studies published on bilharzia and respiratory problems in literature. We found that a high proportion of people with bilharzia report cough, difficulty in breathing, chest pain, sputum production and wheezing. Also, a good number have lung function impairment and abnormalities on X-ray imaging. Blood eosinophils tended to be associated with the respiratory symptoms and imaging abnormalities which suggests that eosinophils may be involved in causing respiratory problems. We conclude that lung problems are common among people with bilharzia although the studies reviewed were small and mostly among people with acute infection. Larger studies are needed to further characterise lung problems in Bilharzia.
UNASSIGNED: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023.
UNASSIGNED: A total of 2243 patients with S. mansoni were reported from 24 case reports, 11 cross-sectional studies, 7 case series, 2 cohort studies and 2 randomized controlled trials. The prevalence of any respiratory symptom was 13.3-63.3% (total number of patients studied, n = 149). The prevalence of the individual symptoms among patients with S. mansoni in whom respiratory symptoms were sought for was as follows: cough (8.3-80.6%, n = 338), dyspnea (1.7-100.0%, n = 200), chest pain (9.0-57.1%, n = 86), sputum production (20.0-23.3%, n = 30) and wheezing (0.0 - 20.0%, n = 1396). The frequency of the symptoms tended to be higher in acute schistosomiasis. Restrictive lung disease was prevalent in 29.0% (9/31). The commonest chest imaging findings reported were nodules (20-90%, n = 103) and interstitial infiltrates (12.5-23.0%, n = 89). Peripheral blood eosinophilia was prevalent in 72.0-100.0% of patients (n = 130) with acute schistosomiasis and correlated with symptoms and imaging abnormalities. Three case reports in chronic S. mansoni reported elevated C-reactive protein, leucocyte, neutrophil and absolute eosinophil counts, eosinophil percentage, IgE and IgG4.
UNASSIGNED: There is a high prevalence of respiratory morbidity among patients with S. mansoni, particularly in the acute stage of the infection, although the studies are relatively small. Larger studies are needed to characterize respiratory morbidity in chronic schistosomiasis and determine the underlying clinical and immunological mechanisms.
Respiratory problems in people with bilharzia Bilharzia causes significant health problems among those affected. However, little is known about respiratory problems associated with bilharzia. We systematically searched for studies published on bilharzia and respiratory problems in literature. We found that a high proportion of people with bilharzia report cough, difficulty in breathing, chest pain, sputum production and wheezing. Also, a good number have lung function impairment and abnormalities on X-ray imaging. Blood eosinophils tended to be associated with the respiratory symptoms and imaging abnormalities which suggests that eosinophils may be involved in causing respiratory problems. We conclude that lung problems are common among people with bilharzia although the studies reviewed were small and mostly among people with acute infection. Larger studies are needed to further characterise lung problems in Bilharzia.
摘要：
■血吸虫病在全球范围内贡献了250万残疾调整生命年。曼氏血吸虫的急性和慢性呼吸道发病率（S.mansoni)在文献中的记载很少。我们对曼氏链球菌患者的呼吸道症状和肺功能异常的负担进行了快速文献综述。我们还报告了所审查研究的免疫学和肺部影像学发现。
■从数据库建立到2023年3月13日，我们在Embase和MEDLINE中进行了全面的文献检索。
■从24例病例报告中，共报告了2243例曼氏球菌患者，11个横断面研究，7个案例系列，2项队列研究和2项随机对照试验。任何呼吸道症状的患病率为13.3-63.3%(研究的患者总数，n=149）。在寻求呼吸道症状的曼氏链球菌患者中，个体症状的患病率如下：咳嗽（8.3-80.6％，n=338),呼吸困难（1.7-100.0%，n=200),胸痛（9.0-57.1%，n=86),痰液产量(20.0-23.3%，n=30)和喘息(0.0-20.0%，n=1396）。急性血吸虫病的症状频率往往较高。限制性肺病患病率为29.0%(9/31)。报告的最常见的胸部影像学发现是结节（20-90％，n=103)和间质渗透(12.5-23.0%，n=89）。72.0-100.0％的急性血吸虫病患者（n=130）普遍存在外周血嗜酸性粒细胞增多，并与症状和影像学异常有关。3例慢性曼氏链球菌报告C反应蛋白升高，白细胞,中性粒细胞和绝对嗜酸性粒细胞计数，嗜酸性粒细胞百分比，IgE和IgG4。
■曼氏链球菌患者的呼吸系统发病率很高，特别是在感染的急性期，虽然研究相对较小。需要更大规模的研究来描述慢性血吸虫病的呼吸道发病率，并确定潜在的临床和免疫机制。
BilharziaBilharzia患者的呼吸系统问题会导致受影响者的严重健康问题。然而,对与bilharzia相关的呼吸问题知之甚少。我们系统地搜索了文献中有关bilharzia和呼吸问题的研究。我们发现很高比例的bilharzia患者报告咳嗽，呼吸困难,胸痛,痰和喘息。此外，相当数量的患者有肺功能受损和X线成像异常.血液嗜酸性粒细胞倾向于与呼吸道症状和影像学异常有关，这表明嗜酸性粒细胞可能与引起呼吸道问题有关。我们得出的结论是，尽管所审查的研究规模很小，而且主要是在急性感染人群中，但肺部问题在bilharzia患者中很常见。需要更大规模的研究来进一步描述Bilharzia的肺部问题。
■从数据库建立到2023年3月13日，我们在Embase和MEDLINE中进行了全面的文献检索。
■从24例病例报告中，共报告了2243例曼氏球菌患者，11个横断面研究，7个案例系列，2项队列研究和2项随机对照试验。任何呼吸道症状的患病率为13.3-63.3%(研究的患者总数，n=149）。在寻求呼吸道症状的曼氏链球菌患者中，个体症状的患病率如下：咳嗽（8.3-80.6％，n=338),呼吸困难（1.7-100.0%，n=200),胸痛（9.0-57.1%，n=86),痰液产量(20.0-23.3%，n=30)和喘息(0.0-20.0%，n=1396）。急性血吸虫病的症状频率往往较高。限制性肺病患病率为29.0%(9/31)。报告的最常见的胸部影像学发现是结节（20-90％，n=103)和间质渗透(12.5-23.0%，n=89）。72.0-100.0％的急性血吸虫病患者（n=130）普遍存在外周血嗜酸性粒细胞增多，并与症状和影像学异常有关。3例慢性曼氏链球菌报告C反应蛋白升高，白细胞,中性粒细胞和绝对嗜酸性粒细胞计数，嗜酸性粒细胞百分比，IgE和IgG4。
■曼氏链球菌患者的呼吸系统发病率很高，特别是在感染的急性期，虽然研究相对较小。需要更大规模的研究来描述慢性血吸虫病的呼吸道发病率，并确定潜在的临床和免疫机制。
BilharziaBilharzia患者的呼吸系统问题会导致受影响者的严重健康问题。然而,对与bilharzia相关的呼吸问题知之甚少。我们系统地搜索了文献中有关bilharzia和呼吸问题的研究。我们发现很高比例的bilharzia患者报告咳嗽，呼吸困难,胸痛,痰和喘息。此外，相当数量的患者有肺功能受损和X线成像异常.血液嗜酸性粒细胞倾向于与呼吸道症状和影像学异常有关，这表明嗜酸性粒细胞可能与引起呼吸道问题有关。我们得出的结论是，尽管所审查的研究规模很小，而且主要是在急性感染人群中，但肺部问题在bilharzia患者中很常见。需要更大规模的研究来进一步描述Bilharzia的肺部问题。
