Food safety has garnered global attention, necessitating advanced methods for the quick and accurate detection of contaminants. Sensors, notable for their ease of use, high sensitivity, and fast analysis, are prominent. Two-dimensional (2D) nanomaterials have been employed to improve sensor performance. Particularly, black phosphorus (BP) stands out with its multifunctional capabilities, attributed to unique layered structure, ultra-high charge mobility, easy surface functionalization, enhanced optical absorption, and tunable direct bandgap. These characteristics suggest that BP could significantly enhance sensor selectivity, sensitivity, and response speed for contaminant detection. Despite numerous studies on BP-based sensors in food safety, few reviews have been comprehensively summarized. Moreover, challenges in BP\'s preparation and stability restrict its wider use. This paper reviews recent research on BP\'s role in food safety, covering preparation, passivation, and applications. Through analysis of challenges and prospects, this review aims to provide insightful guidance for upcoming research in this area.

In many rapidly urbanizing and industrializing countries, atmospheric pollution causes severe environmental problems and compromises the health of humans and ecosystems. Atmospheric emissions, which encompass gases and particulate matter, can be transported back to the earth\'s surface through atmospheric deposition. Atmospheric deposition supplies chemical species that can serve as nutrients and/or toxins to aquatic ecosystems, resulting in wide-ranging responses of aquatic organisms. Among the aquatic organisms, phytoplankton is the basis of the aquatic food web and is a key player in global primary production. Atmospheric deposition alters nutrient availability and thus influences phytoplankton species abundance and composition. This review provides a comprehensive overview of the physiological responses of phytoplankton resulting from the atmospheric deposition of trace metals, nitrogen-containing compounds, phosphorus-containing compounds, and sulfur-containing compounds in particulate matter into aquatic ecosystems. Knowledge gaps and critical areas for future studies are also discussed.

The application of artificial neural networks (ANNs) in the treatment of wastewater has achieved increasing attention, as it enhances the efficiency and sustainability of wastewater treatment plants (WWTPs). This paper explores the application of ANN-based models in WWTPs, focusing on the latest published research work, by presenting the effectiveness of ANNs in predicting, estimating, and treatment of diverse types of wastewater. Furthermore, this review comprehensively examines the applicability of the ANNs in various processes and methods used for wastewater treatment, including membrane and membrane bioreactors, coagulation/flocculation, UV-disinfection processes, and biological treatment systems. Additionally, it provides a detailed analysis of pollutants viz organic and inorganic substances, nutrients, pharmaceuticals, drugs, pesticides, dyes, etc., from wastewater, utilizing both ANN and ANN-based models. Moreover, it assesses the techno-economic value of ANNs, provides cost estimation and energy analysis, and outlines promising future research directions of ANNs in wastewater treatment. AI-based techniques are used to predict parameters such as chemical oxygen demand (COD) and biological oxygen demand (BOD) in WWTP influent. ANNs have been formed for the estimation of the removal efficiency of pollutants such as total nitrogen (TN), total phosphorus (TP), BOD, and total suspended solids (TSS) in the effluent of WWTPs. The literature also discloses the use of AI techniques in WWT is an economical and energy-effective method. AI enhances the efficiency of the pumping system, leading to energy conservation with an impressive average savings of approximately 10%. The system can achieve a maximum energy savings state of 25%, accompanied by a notable reduction in costs of up to 30%.

Integrating algae into constructed wetlands (CWs) enhances wastewater treatment, although the results vary. This review evaluates the role of algae in CWs and the performance of different algae-CW (A-CW) configurations based on literature and meta-analysis. Algae considerably improve N removal, although their impact on other parameters varies. Statistical analysis revealed that 70 % of studies report improved treatment efficiencies with A-CWs, achieving average removal rates of 75 % for chemical oxygen demand (COD), 74 % for total nitrogen and ammonium nitrogen, and 79 % for total phosphorus (TP). This review identifies hydraulic retention times, which average 3.1 days, and their varied impact on treatment efficacy. Mixed-effects models showed a slight increase in COD and TP removal efficiencies of 0.6 % every ten days in the A-CWs. Future research should focus on robust experimental designs, adequate algal storage and separation techniques, and advanced modeling to optimize the treatment potential of algae in CWs.

Calcium (Ca) and phosphorus (P) are minerals involved in biological functions and essential structural components of the skeleton. The body tightly regulates Ca and P to maintain homeostasis. Maternal needs for Ca and P increase during gestation and lactation to support conceptus growth and milk synthesis. Litter size and litter average daily gain (ADG) have a large effect on Ca and P requirements for sows because as they increase, the requirements increase due to a greater need from the sow. The objective of this review was to summarize published literature on Ca and P requirements in gestating and lactating sows derived from empirical data and factorial models. A total of nine empirical studies and seven factorial models were reviewed for determining the Ca and P requirements in gestation. For lactation, there were six empirical studies and seven factorial models reviewed. Empirical studies determined requirements based on the observed effect of Ca and P on bone mineralization, sow and litter performance, and milk characteristics. Factorial models generated equations to estimate Ca and P requirements using the main components of maintenance, fetal and placental growth, and maternal retention in gestation. The main components for factorial equations in lactation include maintenance and milk production. In gestation, the standardized total tract digestible phosphorus (STTD P) requirement estimates from empirical studies range from 5.4 to 9.5 g/d with total Ca ranging from 12.9 to 18.6 g/d to maximize bone measurements or performance criteria. According to the factorial models, the requirements increase throughout gestation to meet the needs of the growing fetuses and range from 7.6 to 10.6 g/d and 18.4 to 38.2 g/d of STTD P and total Ca, respectively, on day 114 of gestation for parity 1 sows. During lactation, STTD P requirement estimates from empirical studies ranged from 8.5 to 22.1 g/d and total Ca ranged from 21.2 to 50.4 g/d. For the lactation factorial models, STTD P requirements ranged from 14.2 to 25.1 g/d for STTD P and 28.4 to 55.6 g/d for total Ca for parity 1 sows with a litter size of 15 pigs. The large variation in requirement estimates makes it difficult to define Ca and P requirements; however, a minimum level of 6.0 and 22.1 g/d of STTD P during gestation and lactation, respectively, appears to be adequate to meet basal requirements. The limited data and high variation indicate a need for future research evaluating Ca and P requirements for gestating and lactating sows.

The increasing trend of using agricultural wastes follows the concept of \"waste to wealth\" and is closely related to the themes of sustainable development goals (SDGs). Carbon-neutral technologies for waste management have not been critically reviewed yet. This paper reviews the technological trend of agricultural waste utilization, including composting, thermal conversion, and anaerobic digestion. Specifically, the effects of exogenous additives on the contents, fractionation, and fate of phosphorus (P) and potentially toxic elements (PTEs) during the composting process have been comprehensively reviewed in this article. The composting process can transform biomass-P and additive-born P into plant available forms. PTEs can be passivated during the composting process. Biochar can accelerate the passivation of PTEs in the composting process through different physiochemical interactions such as surface adsorption, precipitation, and cation exchange reactions. The addition of exogenous calcium, magnesium and phosphate in the compost can reduce the mobility of PTEs such as copper, cadmium, and zinc. Based on critical analysis, this paper recommends an eco-innovative perspective for the improvement and practical application of composting technology for the utilization of agricultural biowastes to meet the circular economy approach and achieve the SDGs.

Wastewater serves as a vital resource for sustainable fertilizer production, particularly in the recovery of nitrogen (N) and phosphorus (P). This comprehensive study explores the recovery chain, from technology to final product reuse. Biomass growth is the most cost-effective method, valorizing up to 95 % of nutrients, although facing safety concerns. Various techniques enable the recovery of 100 % P and up to 99 % N, but challenges arise during the final product crystallization due to the high solubility of ammonium salts. Among these techniques, chemical precipitation and ammonia stripping/ absorption have achieved full commercialization, with estimated recovery costs of 6.0-10.0 EUR kgP-1 and 4.4-4.8 £ kgN-1, respectively. Multiple technologies integrating biomass thermo-chemical processing and P and/or N have also reached technology readiness level TRL = 9. However, due to maturing regulatory of waste-derived products, not all of their products are commercially available. The non-homogenous nature of wastewater introduces impurities into nutrient recovery products. While calcium and iron impurities may impact product bioavailability, some full-scale P recovery technologies deliver products containing this admixture. Recovered mineral nutrient forms have shown up to 60 % higher yield biomass growth compared to synthetic fertilizers. Life cycle assessment studies confirm the positive environmental outcomes of nutrient recycling from wastewater to agricultural applications. Integration of novel technologies may increase wastewater treatment costs by a few percent, but this can be offset through renewable energy utilization and the sale of recovered products. Moreover, simultaneous nutrient recovery and energy production via bio-electrochemical processes contributes to carbon neutrality achieving. Interdisciplinary cooperation is essential to offset both energy and chemicals inputs, increase their cos-efficiency and optimize technologies and understand the nutrient release patterns of wastewater-derived products on various crops. Addressing non-technological factors, such as legal and financial support, infrastructure redesign, and market-readiness, is crucial for successfully implementation and securing the global food production.

Burosumab, a monoclonal antibody directed against the fibroblast growth factor 23 (FGF23), has been approved for the treatment of X-linked hypophosphatemia (XLH). We conducted a systematic review to compare the efficacy and safety of burosumab versus conventional therapy (phosphorus and calcitriol) on XLH treatment. After a comprehensive literature search on MEDLINE/PubMed and Embase, we found nine studies for inclusion in the analysis. Risk of bias was assessed, and a random-effects model was used to determine the effect size. Clinical, biochemical, and radiological parameters of disease severity before and after treatment were analyzed and expressed in standardized mean difference (SMD). Burosumab resulted in normalization of phosphate homeostasis with an increase in renal tubular phosphate reabsorption and significant resolution of skeletal lesions (change in Thacher\'s total rickets severity score SMD: -1.46, 95% confidence interval [CI]: -1.76 to -1.17, p < 0.001, improvement in deformities, and decline in serum alkaline phosphatase levels [SMD: 130.68, 95% CI: 125.26-136.1, p < 0.001)]. Conventional therapy led to similar improvements in all these parameters but to a lower degree. In adults, burosumab normalized phosphorus levels (SMD: 1.23, 95% CI: 0.98-1.47, p < 0.001) with resultant clinical improvement. Burosumab treatment was well tolerated, with only mild treatment-related adverse effects. The present review indicates a potential role for burosumab in improving rickets, deformities, and growth in children with XLH. Given its superior efficacy and safety profile, burosumab could be an effective therapeutic option in children. We suggest further studies comparing burosumab versus conventional therapy in children and adults with XLH.

BACKGROUND: Bariatric surgery (BS) is the most effective treatment for severe obesity and it has beneficial effects on glycemic control and metabolism outcomes. However, the effects of BS on nutritional outcomes are controversial. Therefore, we aimed to evaluate the changes in several nutritional outcomes after Roux-en-Y gastric bypass (RYGB).
METHODS: A comprehensive search was performed using the following databases: PubMed, Embase, Web of Science, Cochrane Library, WanFang and Chinese National Knowledge Infrastructure. The following outcomes were evaluated: vitamin A, 25-hydroxyvitamin D [25(OH)D], calcium, phosphorus, parathormone (PTH), iron, ferritin, vitamin B12, folate, and zinc. The pooled outcomes were expressed as standard mean difference (SMD) and 95% confidence interval (CI) using a random effects model.
RESULTS: Fifty-six studies including 5645 individuals with obesity met the inclusion criteria. Serum 25(OH)D (SMD = 0.78, 95%CI 0.38 to 1.20, P < 0.001), phosphorus (SMD = 0.48, 95%CI 0.22 to 0.74, P < 0.001), PTH (SMD = 0.35, 95%CI 0.11 to 0.59, P = 0.005), vitamin B12 (SMD = 1.11, 95%CI 0.41 to 1.80, P = 0.002), and folate (SMD = 1.53, 95%CI 0.77 to 2.28, P < 0.001) significantly increased after RYGB compared with the baseline. Serum ferritin (SMD =  - 1.67, 95%CI - 2.57 to - 0.77, P < 0.001), vitamin A (SMD =  - 0.64, 95%CI - 0.99 to - 0.29, P < 0.001), and plasma zinc (SMD =  - 0.58, 95%CI - 1.09 to - 0.06, P = 0.027) significantly decreased after RYGB. No significant changes in serum calcium (SMD =  - 0.14, 95%CI - 0.40 to 0.11, P = 0.219) and iron (SMD = 0.26, 95%CI - 0.11 to 0.64, P = 0.165) were observed after RYGB.
CONCLUSIONS: Despite the increased levels of 25(OH)D, phosphorus, vitamin B12 and folate, this meta-analysis revealed the unfavorable nutritional consequences after RYGB.

Some of the biggest changes in mineral nutrition for pigs that have occurred due to recent research were caused by the understanding that there is a loss of endogenous Ca and P into the intestinal tract of pigs. This resulted in development of the concept of formulating diets based on standardized total tract digestibility (STTD) rather than apparent total tract digestibility because the values for STTD of these minerals are additive in mixed diets. There are, however, no recent summaries of research on digestibility and requirements of macro- and microminerals and vitamin D for pigs. Therefore, the objective of this review was to summarize selected results of research conducted over the last few decades to determine the digestibility and requirements of some minerals and vitamin D fed to sows and growing pigs. Benefits of microbial phytase in terms of increasing the digestibility of most minerals have been demonstrated. Negative effects on the growth performance of pigs of over-feeding Ca have also been demonstrated, and frequent analysis of Ca in complete diets and raw materials is, therefore, recommended. There is no evidence that current requirements for vitamin D for weanling or growing-finishing pigs are not accurate, but it is possible that gestating and lactating sows need more vitamin D than currently recommended. Vitamin D analogs and metabolites such as 1(OH)D3 and 25(OH)D3 have beneficial effects when added to diets for sows in combination with vitamin D3. Recent research on requirements for macrominerals other than Ca and P is scarce, but it is possible that Mg in diets containing low levels of soybean meal is marginal. Some of the chelated microminerals have increased digestibility compared with sulfate forms, and hydroxylated forms of Cu and Zn appear to be superior to sulfate or oxide forms. Likewise, dicopper oxide and Cu methionine hydroxy analog have a greater positive effect on the growth performance of growing pigs than copper sulfate. The requirement for Mn may need to be increased whereas there appears to be no benefits of providing Fe above current requirements. In conclusion, diets for pigs should be formulated based on values for STTD of Ca and P and there are negative effects of providing excess Ca in diets. It is possible vitamin D analogs and metabolites offer benefits over vitamin D3 in diets for sows. Likewise, chelated forms of microminerals or chemical forms of minerals other than sulfates or oxides may result in improved pig performance.