nontuberculous mycobacteria (ntm)

非结核分枝杆菌 ( NTM )
  • 文章类型: Case Reports
    免疫重建炎症综合征(IRIS)是一种潜在的威胁生命的现象,与人类免疫缺陷病毒(HIV)感染导致的获得性免疫缺陷综合征患者开始抗逆转录病毒治疗有关。它被认为是对现有病原体或甚至其抗原的夸大的炎症反应。我们在最近开始接受治疗的年轻HIV感染患者中介绍了由于非结核分枝杆菌感染引起的IRIS病例。这个案例强调了做出这样的诊断的挑战以及与肺部和感染性疾病的多学科团队讨论对这些患者的最佳管理的重要性。
    Immune reconstitution inflammatory syndrome (IRIS) is a potentially life-threatening phenomenon associated with the initiation of antiretroviral therapy in patients with acquired immunodeficiency syndrome due to a human immunodeficiency virus (HIV) infection. It is thought to be an exaggerated inflammatory response to an existing pathogen or even its antigen. We present a case of IRIS due to a non-tuberculous mycobacteria infection in a young patient with HIV infection who was recently started on therapy. This case highlights the challenges of making such a diagnosis and the importance of multidisciplinary team discussions with pulmonary and infectious diseases for optimal management of these patients.
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  • 文章类型: Journal Article
    建筑活动是导致水性病原体在建筑水系统中生长和传播的已知风险。该研究的目的是整合对社区和医疗机构中导致水传播疾病的建筑活动风险因素进行分类的证据,确定这些风险因素的严重程度,并确定知识差距。使用系统的审查,纳入标准是:1)对怀疑与建筑活动和水传播病原体有关的疾病病例的研究,and2)activeconstructionworkdescribedinacommunityorhealthcaresetting.在所有研究中,每个建筑活动风险因素都与疾病病例和死亡数量相关,以确定风险严重程度。资格审查和定量综合产生了31项纳入研究(社区,n=7和医疗保健,n=24)。从1965年到2016年,共有894例疾病病例,包括112例死亡,与9个建筑活动危险因素和水传播病原体有关。目前的研究结果支持建筑业主的需要,水管理团队和公共卫生专业人员在正在进行的水管理计划范围内解决施工活动风险因素和当前知识缺陷的分析。建筑活动对水传播疾病的影响是可以预防的,不应再被视为偶然或偶然的。
    Construction activities are a known risk contributing to the growth and spread of waterborne pathogens in building water systems. The purpose of the study is to integrate evidence for categorizing construction activity risk factors contributing to waterborne disease in community and healthcare settings, establish severity of such risk factors and identify knowledge gaps. Using a systematic review, the inclusion criteria were: 1) studies with disease cases suspected to be associated with construction activities and waterborne pathogens, and 2) active construction work described in a community or healthcare setting. Each construction activity risk factor was correlated across all studies with the number of disease cases and deaths to establish risk severity. The eligibility review and quantitative synthesis yielded 31 studies for inclusion (community, n = 7 and healthcare, n = 24). From 1965 to 2016, a total of 894 disease cases inclusive of 112 deaths were associated with nine construction activity risk factors and waterborne pathogens. The present study findings support the need for building owners, water management teams and public health professionals to address construction activity risk factors and the analysis of current knowledge deficiencies within the scope of an ongoing water management program. The impact of construction activities on waterborne disease is preventable and should no longer be considered incidental nor accidental.
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