背景:由于非结核性分枝杆菌肺病(NTM-PD)常见于有骨质疏松症风险的中年/老年苗条女性,我们假设NTM-PD可能与骨质疏松症相关.该研究旨在评估NTM-PD患者与普通人群中骨质疏松症的患病率,并确定受试者中与骨质疏松症相关的因素。包括血清雌二醇(E2)和25-羟基维生素D(25OHD)水平。
方法:我们从庆应义大学医院的一项前瞻性队列研究中招募了228名连续的NTM-PD成年患者,无骨质疏松或骨质疏松相关骨折病史,但在2017年8月至2019年9月期间接受了基于双能X线骨密度仪(BMD)评估.在165例患者中测量了E2和25OHD水平,这些患者具有可获得的储存血清样品。我们对骨量减少和骨质疏松症进行了多变量逻辑回归分析。
结果:在35.1%和36.8%的NTM-PD患者中诊断出骨质疏松(T评分≤-2.5)和骨质减少(T评分-1至-2.5),分别。与普通人群相比,骨质疏松症的比例在50-59-,60-69-,和70-79岁的女性患有NTM-PD。多变量分析显示,年龄较大(1年增长的调整比值比[aOR]=1.12;95%置信区间[CI]=1.07-1.18),女性(aOR=36.3;95%CI=7.57-174),较低的BMI(降低1kg/m2的AOR=1.37;95%CI=1.14-1.65),慢性铜绿假单胞菌(PA)感染(aOR=6.70;95%CI=1.07-41.8)与骨质疏松症独立相关。此外,对165例血清E2和25OHD水平进行多变量分析显示,低E2水平(<10pg/mL)和低25OHD水平与骨质疏松症独立相关。
结论:患有NTM-PD的中年/老年女性骨质疏松症患病率高于普通人群。在NTM-PD中应考虑BMD筛查,特别是在患有严重疾病的老年女性中,如慢性PA感染和较低的BMI,和低血清E2和25OHD水平。
BACKGROUND: Since nontuberculous mycobacterial pulmonary disease (NTM-PD) is common in middle-aged/elderly slender women at risk of osteoporosis, we hypothesized that NTM-PD could be associated with osteoporosis. The
study aimed to evaluate the prevalence of osteoporosis in patients with NTM-PD compared with that in the general population and determine the factors associated with osteoporosis in the subjects, including the serum estradiol (E2) and 25-hydroxyvitamin D (25OHD) levels.
METHODS: We have recruited 228 consecutive adult patients with NTM-PD from a prospective cohort
study at the Keio University Hospital, who had no history of osteoporosis or osteoporosis-associated bone fracture but underwent dual-energy X-ray absorptiometry-based bone mineral density (BMD) evaluation from August 2017-September 2019. The E2 and 25OHD levels were measured in 165 patients with available stored serum samples. We performed multivariable logistic regression analyses for osteopenia and osteoporosis.
RESULTS: Osteoporosis (T-score ≤ - 2.5) and osteopenia (T-score - 1 to - 2.5) were diagnosed in 35.1% and 36.8% of patients with NTM-PD, respectively. Compared with the general population, the proportion of osteoporosis was significantly higher in 50-59-, 60-69-, and 70-79-year-old women with NTM-PD. Multivariable analysis revealed that older age (adjusted odds ratio [aOR] for 1-year increase = 1.12; 95% confidence interval [CI] = 1.07-1.18), female sex (aOR = 36.3; 95% CI = 7.57-174), lower BMI (aOR for 1 kg/m2 decrease = 1.37; 95% CI = 1.14-1.65), and chronic Pseudomonas aeruginosa (PA) infection (aOR = 6.70; 95% CI = 1.07-41.8) were independently associated with osteoporosis. Additionally, multivariable analysis in 165 patients whose serum E2 and 25OHD levels were measured showed that both low E2 levels (< 10 pg/mL) and lower 25OHD levels were independently associated with osteoporosis.
CONCLUSIONS: Middle-aged/elderly women with NTM-PD have a higher prevalence of osteoporosis than the general population. BMD screening should be considered in NTM-PD, especially in older females with severe diseases such as chronic PA infection and lower BMI, and low serum E2 and 25OHD levels.