曲霉属。是新兴的非皮肤癣菌霉菌甲癣(NDMO)的病原体。新曲霉属。最近被描述为导致指甲感染。诊断由曲霉属引起的甲癣需要以下标准。:(1)直接显微镜阳性和(2)曲霉属的重复培养或分子检测。,前提是没有分离出皮肤癣菌。对42项流行病学研究的回顾表明,由曲霉属引起的甲癣。在普通人群中,所有甲癣病例的<1%至35%之间变化,在占71%的糖尿病人群和老年人中更高;在儿童和青少年中非常罕见。曲霉属。占NDMO比例的7.7-100%。涉及脚趾甲的频率是手指甲的25倍。A.黄花,A.terreus和A.niger是最常见的病原物种;描述的其他稀有和新兴物种包括A.tubingensis,A.sydowii,A.alliaceus,A.坎迪斯,A.杂色,A.Unguis,A.Persii,A.硬核,A.uvarum,A.Melleus,A.tamarii和A.nomius。曲霉菌引起的甲癣的临床表现。是非特异性的,但通常是甲真菌病的远端外侧模式。具有阳性KOH的阴性培养物可以指向包括曲霉属物种的NDM。,作为甲癣的病原体。治疗包括特比萘芬或伊曲康唑的全身治疗。
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A
review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence. Aspergillus spp. constitutes 7.7-100% of the proportion of NDMO. The toenails are involved 25 times more frequently than fingernails. A. flavus, A. terreus and A. niger are the most common aetiologic species; other rare and emerging species described include A. tubingensis, A. sydowii, A. alliaceus, A. candidus, A. versicolor, A. unguis, A. persii, A. sclerotiorum, A. uvarum, A. melleus, A. tamarii and A. nomius. The clinical presentation of onychomycosis due to Aspergillus spp. is non-specific but commonly distal-lateral pattern of onychomycosis. A negative culture with a positive KOH may point to a NDM including Aspergillus spp., as the causative agent of onychomycosis. Treatment consists of systemic therapy with terbinafine or itraconazole.