关键词: Candida auris antifungal biofilm infection novel therapy resistance

Mesh : Antifungal Agents / chemistry pharmacology therapeutic use Azoles / pharmacology Candida / drug effects isolation & purification Candidiasis / drug therapy microbiology Drug Resistance, Fungal / drug effects Drug Therapy, Combination Echinocandins / pharmacology Humans Mycology / methods Polyenes / pharmacology Treatment Failure

来  源:   DOI:10.3390/ijms22094470   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported.
摘要:
耳念珠菌是一种新型的主要真菌病原体,在过去十年中引发了几次爆发。治疗真菌疾病的少数药物,这种酵母具有很高的多药耐药率和误导性鉴定的发生,和形成生物膜的能力(自然对药物更有抗性)使得治疗金黄色葡萄球菌感染变得非常困难。本文旨在快速说明C.auris鉴定中的主要问题,可用的治疗方法和相关的耐药机制,以及最近报道的新型和替代治疗和药物(天然和合成)。
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