未经证实:Janus激酶抑制剂(JAKi)是通过抑制细胞膜上的各种细胞因子受体来抑制Janus激酶-信号转导和转录激活因子(JAK-STAT)途径的抗炎药物。JAK和STAT蛋白的突变和多态性可导致免疫系统平衡失调,并最终导致自身免疫性疾病。
UNASSIGNED:记录和总结JAKi在各种自身免疫性疾病如斑秃(AA)中的总体疗效和安全性,寻常型银屑病(PV),银屑病关节炎(PsA),特应性皮炎(AD),白癜风,化脓性汗腺炎(HS),扁平苔藓(LP),和坏疽性脓皮病(PG)。
未经评估:对PubMed和GoogleScholar关于荟萃分析的文章进行了全面审查,系统评价,临床试验和案例研究评估自身免疫性疾病的治疗,如AA,PV,PsA,AD,白癜风,LP,HS,和PG与JAKI。重复数据和动物实验或体外/离体研究被排除。
UNASSIGNED:所有综述的文章都报道了托法替尼和鲁索替尼在治疗上述具有自身免疫易感性的疾病中的有益作用。
UNASSIGNED:托法替尼和鲁索替尼在治疗几种自身免疫性疾病方面显示出潜在的疗效。根据审查的研究记录,两种药物均具有可接受的安全性;然而,建议医生在每种特定情况下使用此类治疗的风险和收益。
UNASSIGNED: Janus kinase inhibitors (JAKi) are anti-inflammatory medications suppressing Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway by inhibiting various cytokines receptors on the membrane of cells. Mutations and polymorphisms on JAK and STAT proteins can cause dysregulation in the balance of immune system, and ultimately result in autoimmune disorders.
UNASSIGNED: To record and summarize the overall efficacy and safety of JAKi in various autoimmune conditions such as alopecia areata (AA), psoriasis vulgaris (PV), psoriatic arthritis (PsA), atopic dermatitis (AD), vitiligo, hidradenitis suppurative (HS), lichen planus (LP), and pyoderma gangrenosum (PG).
UNASSIGNED: A thorough
review of articles was performed across PubMed and Google Scholar on meta-analyses, systematic reviews, clinical trials and case studies evaluating the treatment of autoimmune disorders such as AA, PV, PsA, AD, vitiligo, LP, HS, and PG with JAKi. Duplicated data and animal experiments or in vitro/ex vivo studies were excluded.
UNASSIGNED: All the reviewed articles reported beneficial effects of tofacitinib and ruxolitinib application in the treatment of disorders mentioned above with the autoimmune predisposition.
UNASSIGNED: Tofacitinib and ruxolitinib showed potential efficacy in treating several autoimmune disorders. Based on records in the reviewed studies, both medications had acceptable safety profiles; however, physicians are recommended to outweigh the risks and benefits of such treatments for each specific condition.