在过去的几十年里，微核试验已被认为是监测暴露于许多不同职业因素的人群的合适生物标志物，生活方式,环境条件,辐射暴露,和农药的有害影响。这项工作的目的是指导未来实地研究的设计，以评估儿童暴露于环境诱变剂的风险。辐射,和杀虫剂。这篇评论寻求有关儿童口腔细胞微核分析的可用信息。研究DNA损伤的文献搜索，遗传损伤,口腔细胞,口腔细胞,遗传毒性，诱变和微核始于2000年，计划于5月结束，2022年。简而言之，搜索PubMed,MEDLINE,和谷歌学者为各种文章进行了表演。结果表明，针对暴露于最多样化环境条件的儿童口腔细胞微核的研究仍然很少。只有环境污染与儿童口腔细胞基因组的损害有关。因此,研究人员需要在细胞分析中进行校准，实地研究方案的标准化以及使用微核试验作为儿童生物监测工具对儿童进行评估的新研究的发展。
In the last decades, the micronucleus assay has been recognized as a suitable biomarker for monitoring populations exposed to many different occupational factors, lifestyle, environmental conditions, radiation exposure, and deleterious effects of pesticides. The objective of this work is to direct the design of future field studies in the assessment of the risk of children exposed to environmental mutagens, radiation, and pesticides. This review sought available information on the analysis of micronuclei in oral cells in children. A literature search for papers investigating DNA damage, genetic damage, oral cells, buccal cells, genotoxicity, mutagenicity and micronucleus was begun in 2000 and is scheduled to be concluded in May, 2022. Briefly, a search of PubMed, MEDLINE, and Google Scholar for a variety of articles was performed. The results showed that there are still few studies that addressed micronuclei of oral cells in children exposed to the most diverse environmental conditions. Only environmental pollution was associated with damage to the genome of oral cells in children. Therefore, researchers need to be calibrated in cell analysis, standardization of field study protocols and the development of new research in the evaluation of children using the micronucleus test as a tool in child biomonitoring.
