mesh repair

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  • 文章类型: Journal Article
    疝是一种常见的医学病症,其特征是器官或组织通过弱化的肌肉壁突出,每年影响全球数百万人。历史上,使用无张力网眼修复进行开放式手术治疗,疝气修复的景观有了显著的发展。这种演变的标志是微创技术的出现和完善,包括腹腔镜和机器人辅助方法,减少术后疼痛,更短的恢复时间,与传统方法相比,改善了患者的预后。这篇全面的综述旨在阐明疝气修复技术的演变,强调从传统的网状修复过渡到先进的微创方法。通过检查疝气手术的历史进展和现状,这篇综述彻底分析了外科技术的进步,材料,和技术。此外,它探索了生物网格等新兴趋势,超声引导程序,以及3D打印在疝修补术中的应用。这些进步的临床意义在于其提高患者生活质量的潜力,尽量减少并发症,优化医疗资源利用。从这篇综述中获得的见解将告知临床医生和研究人员关于疗效,安全,和各种疝修补术的比较效果,指导未来疝气管理方向,促进外科实践创新。
    Hernias are a common medical condition characterized by the protrusion of organs or tissues through weakened muscle walls, affecting millions worldwide annually. Historically, from being treated with open surgeries using tension-free mesh repairs, the landscape of hernia repair has evolved significantly. This evolution has been marked by the advent and refinement of minimally invasive techniques, including laparoscopic and robotic-assisted approaches, which offer reduced postoperative pain, shorter recovery times, and improved patient outcomes compared to traditional methods. This comprehensive review aims to elucidate the evolution of hernia repair techniques, emphasizing the transition from conventional mesh repairs to advanced minimally invasive methodologies. By examining the historical progression and current state of hernia surgery, this review thoroughly analyzes the advancements in surgical techniques, materials, and technologies. Furthermore, it explores emerging trends such as biological meshes, ultrasound-guided procedures, and 3D printing applications in hernia repair. The clinical significance of these advancements lies in their potential to enhance the patient\'s quality of life, minimize complications, and optimize healthcare resource utilization. Insights gained from this review will inform clinicians and researchers about the efficacy, safety, and comparative effectiveness of various hernia repair approaches, guiding future directions in hernia management and fostering innovation in surgical practice.
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  • 文章类型: Journal Article
    背景:腹疝是终末期肾病(ESKD)患者中常见的手术问题,而小腹侧疝的最佳修复技术是有争议的。本研究旨在比较ESKD患者缺损大小≤2cm的小腹侧疝的开放缝合修复与生物网状修复的结果。
    方法:回顾性分析了2012年1月至2022年1月在单个机构接受选择性腹侧疝修补术且缺损大小≤2cm的ESKD患者的数据。将开放缝线修复的结果与PermacolTM网状修复进行比较。主要结果是复发率。次要结果包括术后并发症,围手术期和术后透析方案。
    结果:纳入47例腹疝修补术,其中20个是缝合修复,27个是PermacolTM网状修复。疝修补术的中位年龄为60岁(范围32-81岁)。术前,42例(89.4%)进行腹膜透析(PD)。脐旁疝(59.6%)最常见。平均疝缺损大小为15mm(范围2-20mm)。中位随访56个月(范围9-119个月),缝合修复组中更多患者出现复发(30%vs.0%,p=0.004)。中位复发时间为10个月(5-16个月)。没有伤口或网状物感染。大多数患者围手术期接受间歇性PD,并且从长远来看能够恢复PD。
    结论:腹侧疝修补术适用于ESKD患者,即使是小缺损;与缝合修补术相比,PermacolTM网片修补术的复发率较低,术后发病率较低。
    BACKGROUND: Ventral hernia is a common surgical problem among patients with end-stage kidney disease (ESKD), while the optimal repair technique for small ventral hernias is controversial. This study aimed to compare the outcomes of open suture repair versus biological mesh repair of small ventral hernias with defect size ≤2 cm in ESKD patients.
    METHODS: Data from consecutive ESKD patients who underwent elective ventral hernia repair with defect size ≤2 cm at a single institution from January 2012 to January 2022 were retrospectively reviewed. Outcomes of open suture repair were compared to PermacolTM mesh repair. The primary outcome was recurrence rate. Secondary outcomes included post-operative complications, peri-operative and post-operative dialysis regimen.
    RESULTS: Forty-seven ventral hernia repairs were included, with 20 being suture repairs and 27 being PermacolTM mesh repairs. Median age at hernia repair was 60 (range 32-81) years old. Pre-operatively, 42 patients (89.4%) were on peritoneal dialysis (PD). Paraumbilical hernia (59.6%) was most common. Median hernia defect size was 15 mm (range 2-20 mm). Upon median follow-up of 56 (range 9-119) months, more patients in the suture repair group developed recurrence (30% vs. 0%, p = 0.004). Median time to recurrence was 10 (range 5-16) months. There was no wound or mesh infection. The majority of patients underwent intermittent PD peri-operatively and were able to resume on PD in the long run.
    CONCLUSIONS: Ventral hernia repair is indicated in ESKD patients even for small defects; repair with PermacolTM mesh was associated with a lower recurrence rate when compared to suture repair and post-operative morbidity was low.
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  • 文章类型: Case Reports
    纤维瘤,虽然组织学上通常是良性的,可以表现出局部攻击行为,尤其是位于前腹壁时。本病例报告探讨了一种罕见的巨大纤维瘤并发淋巴水肿的治疗方法。强调诊断的细微差别,治疗决定,以及它们对患者生活质量的影响。病人,一名55岁的肥胖者,BMI为47,右侧脐带旁区域有25厘米的肿块,伴随着右下肢明显的淋巴水肿和相关的腹股沟淋巴结肿大。腹部CT显示右旁正中下区有明确的软组织肿块,提示硬纤维瘤。手术干预包括对5厘米外侧缘的肿块进行整体切除,包括右侧腹直肌和相关的腱神经,以及随后使用双面腹膜内合成网进行重建。术后恢复的标志是淋巴水肿的消退和受影响肢体的全部功能恢复。组织病理学检查证实了硬纤维瘤的诊断。此病例强调了根治性手术切除并具有足够的切缘和适当的重建以实现有利的长期结果的重要性。该报告为未来的研究和治疗进展提供了见解。
    Desmoid tumors, while generally benign histologically, can exhibit locally aggressive behavior, especially when located in the anterior abdominal wall. This case report explores the management of a rare giant desmoid tumor complicated by concurrent lymphedema, emphasizing the nuances of diagnosis, treatment decisions, and their impact on the patient\'s quality of life. The patient, a 55-year-old obese individual with a BMI of 47, presented with a 25 cm mass in the right paraumbilical region, alongside significant lymphedema in the right lower limb and associated inguinal lymphadenopathy. Abdominal CT revealed a well-defined soft tissue mass in the right paramedian hypogastric region, suggestive of a desmoid tumor. Surgical intervention involved a monobloc resection of the mass with a 5 cm lateral margin, including the right rectus abdominis muscle and associated aponeuroses, and subsequent reconstruction using a biface intraperitoneal synthetic mesh. Postoperative recovery was marked by the resolution of lymphedema and a return to full function of the affected limb. Histopathological examination confirmed the diagnosis of a desmoid tumor. This case underscores the importance of radical surgical resection with adequate margins and appropriate reconstruction to achieve favorable long-term outcomes. The report provides insights for future research and therapeutic advancements in the management of desmoid tumors.
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  • 文章类型: Case Reports
    弓状线疝通常是无症状的,腹膜内结构在弧线上的上升突起。文献中很少报道弓状线疝。只发现了一些出版物。也没有发表关于修复技术的明确描述。我们的目标是提供诊断图像,并说明我们修复这种疝的方法。
    An arcuate line hernia is a generally asymptomatic, ascending protrusion of intraperitoneal structures over the linea arcuata. Arcuate line herniae are scarcely reported in the literature. Only a few publications were found. No clear descriptions of the techniques for repair have been published either. We aim to provide diagnostic images and illustrate our method to repair this hernia.
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  • 文章类型: Journal Article
    背景:食管裂孔疝(HH)修复与高复发率相关。本研究旨在调查患者自我报告的GERD健康相关生活质量(HRQL)评分随时间的变化是否与长期手术结果相关。
    方法:对2018年至2022年在三级护理中心进行腹腔镜或机器人HH修复的所有患者进行了回顾性图表回顾。收集了关于初始BMI的信息,内窥镜HH测量,手术,术前和术后HRQL评分。然后评估手术修复后至少一年的重复成像是否有任何复发的证据。配对t检验用于比较术前和术后HRQL评分。使用Wilcoxon排名和检验来比较不同时间点复发队列和非复发队列之间的HRQL评分。
    结果:共有126例患者接受了HH修复,并有术前和术后HRQL评分。网格用于23次维修(18.25%)。42例患者记录HH复发(33.3%),35人没有复发的证据(27.7%),49例患者(38.9%)没有随访影像学检查。术前平均QOL评分为24.99(SD±14.95),术后2周时显著提高至5.63(SD±8.51)(p<0.0001)。这种改善在术后1年持续(平均7.86,SD±8.26,p<0.0001)。初次手术至复发的平均时间为2.1年(SD±1.10)。网状修复的复发可能性明显较小(p=0.005)。2周时QOL评分无显著差异,3个月,6个月,或术后1年之间的队列(p=NS)。
    结论:患者术后HH修复术后HRQL评分有长期显著改善,尽管复发。对HH复发患者重新干预的需要应基于其QOL评分,而不一定基于已确定的复发。
    BACKGROUND: Hiatal hernia (HH) repairs have been associated with high recurrence rates. This study aimed to investigate if changes in patient\'s self-reported GERD health-related quality of life (HRQL) scores over time are associated with long-term surgical outcomes.
    METHODS: Retrospective chart reviews were conducted on all patients who had laparoscopic or robotic HH repairs between 2018 and 2022 at a tertiary care center. Information was collected regarding initial BMI, endoscopic HH measurement, surgery, and pre- and post-operative HRQL scores. Repeat imaging at least a year following surgical repair was then evaluated for any evidence of recurrence. Paired t tests were used to compare pre- and post-operative HRQL scores. Wilcoxon ranked-sum tests were used to compare the HRQL scores between the recurrence cohort and non-recurrence cohorts at different time points.
    RESULTS: A total of 126 patients underwent HH repairs and had pre- and post-operative HRQL scores. Mesh was used in 23 repairs (18.25%). 42 patients had recorded HH recurrences (33.3%), 35 had no evidence of recurrence (27.7%), and 49 patients (38.9%) had no follow-up imaging. The average pre-operative QOL score was 24.99 (SD ± 14.95) and significantly improved to 5.63 (SD ± 8.51) at 2-week post-op (p < 0.0001). That improvement was sustained at 1-year post-op (mean 7.86, SD ± 8.26, p < 0.0001). The average time between the initial operation and recurrence was 2.1 years (SD ± 1.10). Recurrence was significantly less likely with mesh repairs (p = 0.005). There was no significant difference in QOL scores at 2 weeks, 3 months, 6 months, or 1 year postoperatively between the cohorts (p = NS).
    CONCLUSIONS: Patients had significant long-term improvement in their HRQL scores after surgical HH repair despite recurrences. The need to re-intervene in patients with HH recurrence should be based on their QOL scores and not necessarily based on established recurrence.
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  • 文章类型: Journal Article
    目标:随着日本社会的老龄化,老年食管裂孔疝(HH)患者的手术数量正在增加.在这项研究中,我们检查了可行性,安全,在老年日本HH患者中,在有或没有网状修复和/或胃底折叠术的情况下,在组织成形术中增加前胃切除术的潜在有效性。
    方法:我们回顾性评估了2010年至2021年间接受腹腔镜HH修复的39例患者。我们根据年龄将他们分为两组:“年轻”组(<75岁,n=21),和“老年”组(≥75岁,n=18)。病人的特点,术中数据,收集术后结果。
    结果:年轻和老年组的平均年龄分别为68和82岁,分别,两组之间的女性比例相似(年轻vs.年龄:67%vs.78%,p=0.44)。老年组比年轻组有更多的III/IV型HH病例(19%vs.83%,p<0.001)。老年组手术时间长于年轻组,但在失血方面没有显著差异,围手术期并发症,或术后住院时间。老年组的前胃切除术病例明显增多(0%vs.78%,p<0.001)和较少的胃底折叠(100%vs.67%,p=0.004)比年轻组。两组之间的HH复发没有显着差异(5%vs.11%,p=0.46)。
    结论:在其他手术中增加前胃切除术是可行的,安全,对日本老年HH患者可能有效。
    OBJECTIVE: As Japanese society ages, the number of surgeries performed in elderly patients with hiatal hernia (HH) is increasing. In this study, we examined the feasibility, safety, and potential effectiveness of the addition of anterior gastropexy to hiatoplasty with or without mesh repair and/or fundoplication in elderly Japanese HH patients.
    METHODS: We retrospectively evaluated 39 patients who underwent laparoscopic HH repair between 2010 and 2021. We divided them into 2 groups according to age: the \"younger\" group (< 75 years old, n = 21), and the \"older\" group (≥ 75 years old, n = 18). The patient characteristics, intraoperative data, and postoperative results were collected.
    RESULTS: The median ages were 68 and 82 years old in the younger and older groups, respectively, and the female ratio was similar between the groups (younger vs. older: 67% vs. 78%, p = 0.44). The older group had more type III/IV HH cases than the younger group (19% vs. 83%, p < 0.001). The operation time was longer in the older group than in the younger group, but there was no significant difference in blood loss, perioperative complications, or postoperative length of stay between the groups. The older group had significantly more cases of anterior gastropexy (0% vs. 78%, p < 0.001) and less fundoplication (100% vs. 67%, p = 0.004) than the younger group. There was no significant difference in HH recurrence between the groups (5% vs. 11%, p = 0.46).
    CONCLUSIONS: The addition of anterior gastropexy to other procedures is feasible, safe, and potentially effective in elderly Japanese patients with HH.
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  • 文章类型: Journal Article
    目的:切口疝(IH)是腹部手术后常见的并发症。IH的手术修复与症状的缓解和生活质量的改善有关。手术干预可能对患者和医疗保健设施造成重大负担。本研究旨在描述和比较IH的择期和急诊手术修复的结果。
    方法:本研究是一项单中心回顾性对比研究,包括IH修复患者。患者分为I组(急诊)和II组(选择性),并在它们之间进行了比较。
    结果:确定了200名患者,平均年龄为61.8±14.2岁,其中152人(58%)为女性。平均BMI为31.6±7.2kg/m2。超过58%有至少一种合并症。169例(64.5%)患者接受了选择性修复,93人(35.5%)接受了紧急维修。接受紧急修复的患者年龄明显较大,BMI较高,分别为p=0.031和p=0.002。显著并发症发生率(Clavien-DindoIII和IV)为9.54%。30天和90天死亡率分别为2.3%(n=6)和2.68%(n=7),分别。在紧急小组中,整体并发症,30天和90天的死亡率明显高于选修组,p分别≤0.001、0.002和0.001。总的来说,42(16.1%)出现伤口并发症,25(9.6%)经历了复发,41例(15.71%)在90天内再次入院,两组之间无显著差异。
    结论:接受急诊修复的患者明显年龄较大,BMI高于择期病例。急诊IH修复比选择性修复具有更高的并发症发生率和死亡率。
    OBJECTIVE: Incisional hernia (IH) is a common complication following abdominal surgery. Surgical repair of IH is associated with the alleviation of symptoms and improvement of quality of life. Operative intervention can pose a significant burden to the patient and healthcare facilities. This study aims to describe and compare outcomes of elective and emergency surgical repair of IH.
    METHODS: This study is a single-centre comparative retrospective study including patients who had repair of IH. Patients were divided into Group I (Emergency) and Group II (Elective), and a comparison was conducted between them.
    RESULTS: Two hundred sixty-two patients were identified with a mean age of 61.8 ± 14.2 years, of which 152 (58%) were females. The mean BMI was 31.6 ± 7.2 kg/m2. More than 58% had at least one comorbidity. 169 (64.5%) patients had an elective repair, and 93 (35.5%) had an emergency repair. Patients undergoing emergency repair were significantly older and had higher BMI, p = 0.031 and p = 0.002, respectively. The significant complication rate (Clavien-Dindo III and IV) was 9.54%. 30 and 90-day mortality rates were 2.3% (n = 6) and 2.68% (n = 7), respectively. In the emergency group, the overall complications, 30-day and 90-day mortality rates were significantly higher than in the elective group, p ≤ 0.001, 0.002 and 0.001, respectively. Overall, 42 (16.1%) developed wound complications, 25 (9.6%) experienced a recurrence, and 41 (15.71%) were readmitted within 90 days, without significant differences between the two groups.
    CONCLUSIONS: Patients who underwent emergency repair were significantly older and had a higher BMI than the elective cases. Emergency IH repair is associated with higher complication rates and mortality than elective repair.
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  • 文章类型: Journal Article
    目的:女性腹壁疝修补术患病率最高。上腹部疝修补术后的结果很少独立报道。尽管病理和手术技术可能与其他原发性腹侧疝不同。这项研究的目的是在全国范围内评估女性上腹疝修补术后的长期结局。方法:来自丹麦疝数据库的全国队列研究。提取了12年(2007-2018年)期间接受择期腹壁疝修补术的妇女的完整数据。通过结合来自国家民事登记册的数据获得了100%的随访。主要结果是手术复发,次要结局是并发症的再入院和手术治疗.开放性缝合修复的结果,开放网格修复网格,与腹腔镜修补术进行比较。结果:总的来说,3,031名妇女在研究期间接受了择期腹壁疝修补术。约1,671名(55.1%)妇女接受了开放性缝合修复,796(26.3%)接受了开放网孔修复,564(18.6%)接受了腹腔镜修复。随访时间中位数为4.8年。缝合修复后复发的手术率高于开放网片和腹腔镜修复后(7.7%vs.3.3%,vs.6.2%,p<0.001)。与缝合修补术和腹腔镜修补术相比,开放网片修补术后并发症的手术风险略高(2.6%vs.1.2%,vs.2.0%,p=0.032),开放网眼组的伤口并发症手术更多(2.0%,p=0.006)。结论:超过一半的女性接受了缝合修复,虽然网状修复降低了复发的风险。开放网片修复术后复发风险最低,但费用略有增加伤口相关并发症的风险。
    Aim: Women have the highest prevalence of epigastric hernia repair. Outcomes after epigastric hernia repair are rarely reported independently, although pathology and surgical techniques may be different than for other primary ventral hernias. The aim of this study was to evaluate long-term outcomes after epigastric hernia repairs in women on a nationwide basis. Methods: Nationwide cohort study from the Danish Hernia Database. Complete data from women undergoing elective epigastric hernia repair during a 12 years period (2007-2018) was extracted. A 100% follow-up was obtained by combining data from the National Civil Register. The primary outcome was operation for recurrence, secondary outcomes were readmission and operation for complications. Outcomes for open sutured repair, open mesh repair mesh, and laparoscopic repairs were compared. Results: In total, 3,031 women underwent elective epigastric hernia repair during the study period. Some 1,671 (55.1%) women underwent open sutured repair, 796 (26.3%) underwent open mesh repair, and 564 (18.6%) underwent laparoscopic repair. Follow-up was median 4.8 years. Operation for recurrence was higher after sutured repairs than after open mesh and laparoscopic repairs (7.7% vs. 3.3%, vs. 6.2%, p < 0.001). The risk of operation for complications was slightly higher after open mesh repair compared with sutured repair and laparoscopic repair (2.6% vs. 1.2%, vs. 2.0%, p = 0.032), with more operations for wound complications in the open mesh group (2.0%, p = 0.006). Conclusion: More than half of the women underwent a suture-based repair, although mesh repair reduces risk of recurrence. Open mesh repair had the lowest risk of recurrence, but on the expense of slightly increased risk of wound-related complications.
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  • 文章类型: Journal Article
    腹壁重建(AWR)是一种外科手术,用于解决各种疾病,例如疝气,切口疝,和复杂的腹壁缺损。网格固定在AWR期间为弱化的腹壁提供机械增强中起着至关重要的作用。传统上,缝合一直是网片固定的首选方法;然而,作为一种替代方法,使用组织粘合剂或胶水的粘附技术已经受到关注。本系统综述旨在比较AWR网片固定的缝合和粘连技术,并评估其预防疝气复发的有效性。在相关数据库中进行了全面的文献检索,包括PubMed,MEDLINE,Embase,还有Cochrane图书馆.包括满足预定资格标准的研究。感兴趣的主要结果指标是疝复发率。次要结果包括网状相关并发症,手术部位感染,患者报告的结果,和功能结果。对纳入的研究进行了偏倚风险评估,数据进行了定性合成。总的来说,纳入研究的结果提示,用胶进行无创伤网片固定可能具有减轻慢性腹股沟疼痛(CGP)的潜力.然而,患者选择标准存在显著差异,胶水管理技术,试验中的疝修复方法,这限制了得出明确结论的能力。此外,CGP的定义和术后疼痛的测量量表在研究中各不相同,使比较结果具有挑战性。审查的局限性包括在一些试验中样本量小,随访持续时间相对较短,以及缺乏评估异物感和腹股沟顺应性等变量的标准化标准。此外,与传统缝线固定相比,使用胶水固定的经济意义需要考虑。
    Abdominal wall reconstruction (AWR) is a surgical procedure performed to address various conditions such as hernias, incisional hernias, and complex abdominal wall defects. Mesh fixation plays a crucial role in providing mechanical reinforcement to the weakened abdominal wall during AWR. Traditionally, suturing has been the preferred method for mesh fixation; however, adhesion techniques using tissue adhesives or glues have gained attention as an alternative approach. This systematic review aims to compare suturing and adhesion techniques for mesh fixation in AWR and assess their effectiveness in preventing hernia recurrence. A comprehensive literature search was conducted across relevant databases, including PubMed, MEDLINE, Embase, and the Cochrane Library. Studies that fulfilled the predetermined eligibility criteria were included. The primary outcome measure of interest was hernia recurrence rates. Secondary outcomes included mesh-related complications, surgical site infections, patient-reported outcomes, and functional outcomes. A risk of bias assessment was performed for the included studies, and data were synthesized qualitatively. Overall, the results of the included studies suggest that atraumatic mesh fixation with glue may have the potential to reduce chronic groin pain (CGP). However, there were significant variations in patient selection criteria, glue administration techniques, and hernia repair methods among the trials, which limited the ability to draw definitive conclusions. Additionally, the definitions of CGP and measurement scales for postoperative pain varied across studies, making it challenging to compare outcomes. The limitations of the review include the small sample sizes in some trials, relatively short follow-up durations, and the lack of standardized criteria for assessing variables such as foreign body sensation and groin compliance. Furthermore, the economic implications of using glue fixation compared to traditional suture fixation need to be considered.
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  • 文章类型: Journal Article
    切口疝(IH)是腹部手术后的常见并发症。IH的发展可能比腹壁的简单解剖故障更复杂。报告的IH发病率因研究而异。这篇综述概述了定义,分子基础,危险因素,发病率,临床表现,外科技术,术后护理,成本,风险预测工具,并提出了预防措施。对PubMed进行了文献检索,以纳入关于IH的高质量研究。IH的发病率取决于原发性手术病理,切口部位和范围,相关的医疗合并症,和风险因素。审查强调了固有和可改变的风险因素。细胞外基质的解体,成纤维细胞功能缺陷,不同胶原蛋白类型的比例变化与分子机制有关。IH的选择性修复可缓解症状,预防并发症,并提高了生活质量(QOL)。最近的研究引入了风险预测工具来实施预防措施,包括缝合线加固或在高危人群中预防性应用网状物。选择性修复可改善QOL并防止与紧急IH修复相关的险恶结果。应该审查警惕的等待策略,在患者咨询期间,应彻底讨论各种选择。用于预测IH的风险分层工具将有助于采取预防措施。
    Incisional hernia (IH) is a frequent complication following abdominal surgery. The development of IH could be more sophisticated than a simple anatomical failure of the abdominal wall. Reported IH incidence varies among studies. This review presented an overview of definitions, molecular basis, risk factors, incidence, clinical presentation, surgical techniques, postoperative care, cost, risk prediction tools, and proposed preventative measures. A literature search of PubMed was conducted to include high-quality studies on IH. The incidence of IH depends on the primary surgical pathology, incision site and extent, associated medical comorbidities, and risk factors. The review highlighted inherent and modifiable risk factors. The disorganisation of the extracellular matrix, defective fibroblast functions, and ratio variations of different collagen types are implicated in molecular mechanisms. Elective repair of IH alleviates symptoms, prevents complications, and improves the quality of life (QOL). Recent studies introduced risk prediction tools to implement preventative measures, including suture line reinforcement or prophylactic mesh application in high-risk groups. Elective repair improves QOL and prevents sinister outcomes associated with emergency IH repair. The watchful wait strategy should be reviewed, and options should be discussed thoroughly during patients\' counselling. Risk stratification tools for predicting IH would help adopt prophylactic measures.
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