livestock

家畜
  • 文章类型: Journal Article
    对农产品日益增长的需求,在绿色革命的推动下,导致粮食产量大幅增加。然而,需求正在超过生产,使粮食安全成为一个主要问题,尤其是在气候变化下。印度农业部门极易受到极端降雨的影响,干旱,害虫,和目前气候变化情景中的疾病。尽管如此,畜牧业等重点农业子行业,水稻种植,生物质燃烧也显著增加了温室气体(GHG)的排放,全球气候变化的驱动力。仅农业活动就占全球温室气体排放量的10-12%。印度是农业经济和全球粮食生产的中心,这是由导致自然资源恶化的密集农业投入来满足的。它还占该国温室气体排放总量的14%。因此,确定该部门的驱动因素和最佳缓解策略对于严格的温室气体缓解至关重要。因此,这篇综述旨在确定和阐述印度农业温室气体排放的关键驱动因素,并提出现有文献中可用的最佳策略。这将有助于科学界,政策制定者,和利益攸关方评估当前的农业实践,并坚持现有的最佳方法。我们还讨论了社会经济,和环境影响,以了解集约化农业可能产生的影响。最后,我们研究了当前的国家气候政策,进一步研究的领域,和政策修正案,以帮助弥合研究人员之间的知识差距,政策制定者,和公众对温室气体减排目标的国家利益。
    The growing demand for agricultural products, driven by the Green Revolution, has led to a significant increase in food production. However, the demand is surpassing production, making food security a major concern, especially under climatic variation. The Indian agriculture sector is highly vulnerable to extreme rainfall, drought, pests, and diseases in the present climate change scenario. Nonetheless, the key agriculture sub-sectors such as livestock, rice cultivation, and biomass burning also significantly contribute to greenhouse gas (GHG) emissions, a driver of global climate change. Agriculture activities alone account for 10-12% of global GHG emissions. India is an agrarian economy and a hub for global food production, which is met by intensive agricultural inputs leading to the deterioration of natural resources. It further contributes to 14% of the country\'s total GHG emissions. Identifying the drivers and best mitigation strategies in the sector is thus crucial for rigorous GHG mitigation. Therefore, this review aims to identify and expound the key drivers of GHG emissions in Indian agriculture and present the best strategies available in the existing literature. This will help the scientific community, policymakers, and stakeholders to evaluate the current agricultural practices and uphold the best approach available. We also discussed the socio-economic, and environmental implications to understand the impacts that may arise from intensive agriculture. Finally, we examined the current national climate policies, areas for further research, and policy amendments to help bridge the knowledge gap among researchers, policymakers, and the public in the national interest toward GHG reduction goals.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    在2000年代中期到2010年代初,国内乙醇行业大幅增长,乙醇副产品成为植物盈利能力和牲畜饲养的重要因素。最初作为补充收入来源,乙醇生产的副产品已经演变成多样化的增值产品,加强收入来源,维持利润率。本研究回顾了乙醇副产物的现有经济研究,详细的方法论,产品焦点,和研究地点。最初从9个数据库收集972篇文章,合成了110篇文章。我们发现,大多数研究主要考察了乙醇行业的增长和未来,而对特定副产品的关注有限。饲料用酒糟,尤其是干酒糟,是最广泛出版的,而较新的副产品,如造粒,去油,和高蛋白酒糟的研究相对较少。非饲料产品明显被忽视,强调需要超越常规应用进行探索。乙醇副产品不断发展的市场格局已经超过了已发表的对经济权衡的学术理解,需要进一步研究产品动态,定价,市场营销,市场结构,和监管框架。这突出并强调了调查不同商品和地理背景下的增值谷物的重要性,以便为战略决策和政策制定提供信息。
    During the mid-2000s to the early 2010s, the domestic ethanol industry witnessed substantial growth, with ethanol coproducts emerging as vital elements for plant profitability and livestock feeding. Initially serving as supplementary revenue streams, coproducts from ethanol production have evolved into diverse value-added offerings, bolstering revenue streams, and sustaining profit margins. This study reviews existing economic research on ethanol coproducts, detailing methodologies, product focus, and research locations. Initially gathering 972 articles from 9 databases, 110 articles were synthesized. We find that most studies primarily examined the growth and future of the ethanol industry with a limited focus on specific coproducts. Feed-use distillers\' grains, especially dried distillers\' grains, were the most widely published while newer coproducts like pelletized, de-oiled, and high-protein distillers\' grains were relatively understudied. Non-feed-use products were notably overlooked, highlighting the need for exploration beyond conventional applications. The evolving market landscape for ethanol co-products has surpassed published academic understanding of the economic tradeoffs necessitating further research into product dynamics, pricing, marketing, market structures, and regulatory frameworks. This highlights and underscores the importance of investigating value-added grains across diverse commodities and geographic contexts to inform strategic decision-making and policy formulation.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    动物在应对挑战方面的成功,利用机会茁壮成长,是其福利的核心。功能能力描述了分子的能力,细胞,器官,身体系统,整个动物,和它的社区来缓冲环境扰动的影响。这种缓冲能力决定了动物在面对环境扰动时保持或恢复功能的能力,这被认为是韧性。生理调节的准确性和体内平衡的维持保证了生物节律等结果的动态稳定性,饲料摄入量,增长,牛奶产量,和鸡蛋产量证明他们作为恢复力指标的评估是合理的。这篇叙述性综述考察了环境丰富的影响,特别是在幼小动物的发育阶段,在建设职能能力和随后表现为复原力方面。丰富环境的经验可以在多个功能领域建立技能和能力,包括但不限于行为,豁免权,和新陈代谢,从而在畜牧业实践等挑战的背景下提高功能能力并促进复原力,社会变革,和感染。测量功能容量分布特性的定量方法可以改善其评估。用于分析生态系统中的嵌入式能量(能值)的方法可能对此目标具有实用性。我们建议功能能力提供了将环境丰富与表达弹性能力联系起来的共同点,并可能为测量和报告弹性提供新颖有用的框架。我们得出的结论是,功能能力的发展及其随后作为韧性的表达是积极动物福利的一个方面。从系统动力学中出现的韧性凸显了需要从对身体和精神状态的研究转向对身体和心理动力学的研究,以描述动物福利的积极维度。
    The success of the animal in coping with challenges, and in harnessing opportunities to thrive, is central to its welfare. Functional capacity describes the capacity of molecules, cells, organs, body systems, the whole animal, and its community to buffer against the impacts of environmental perturbations. This buffering capacity determines the ability of the animal to maintain or regain functions in the face of environmental perturbations, which is recognised as resilience. The accuracy of physiological regulation and the maintenance of homeostatic balance underwrite the dynamic stability of outcomes such as biorhythms, feed intake, growth, milk yield, and egg production justifying their assessment as indicators of resilience. This narrative review examines the influence of environmental enrichments, especially during developmental stages in young animals, in building functional capacity and in its subsequent expression as resilience. Experience of enriched environments can build skills and competencies across multiple functional domains including but not limited to behaviour, immunity, and metabolism thereby increasing functional capacity and facilitating resilience within the context of challenges such as husbandry practices, social change, and infection. A quantitative method for measuring the distributed property of functional capacity may improve its assessment. Methods for analysing embedded energy (emergy) in ecosystems may have utility for this goal. We suggest functional capacity provides the common thread that links environmental enrichments with an ability to express resilience and may provide a novel and useful framework for measuring and reporting resilience. We conclude that the development of functional capacity and its subsequent expression as resilience is an aspect of positive animal welfare. The emergence of resilience from system dynamics highlights a need to shift from the study of physical and mental states to the study of physical and mental dynamics to describe the positive dimension of animal welfare.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    抗菌肽(AMP),通常被称为自然抗生素,在生物体中无处不在,从细菌到人类。他们的效力,多功能性,和独特的作用机制已经获得了重要的研究关注。不像传统的抗生素,肽是可生物降解的,这增加了他们作为解决畜牧业中细菌耐药性的潜在候选者的吸引力,这是一个几十年来一直受到审查的挑战。这个问题是复杂和多方面的,受多种成分的影响。世界卫生组织(WHO)提出了一种称为“一个健康”的综合方法,在应对此类挑战时,强调人与动物-环境关系的相互联系。这篇综述探讨了AMP在畜牧业中的应用,以及它们如何在OneHealth框架内减轻这种做法的影响。
    Antimicrobial peptides (AMPs), often referred to as nature\'s antibiotics, are ubiquitous in living organisms, spanning from bacteria to humans. Their potency, versatility, and unique mechanisms of action have garnered significant research attention. Unlike conventional antibiotics, peptides are biodegradable, adding to their appeal as potential candidates to address bacterial resistance in livestock farming-a challenge that has been under scrutiny for decades. This issue is complex and multifactorial, influenced by a variety of components. The World Health Organization (WHO) has proposed a comprehensive approach known as One Health, emphasizing the interconnectedness of human-animal-environment relationships in tackling such challenges. This review explores the application of AMPs in livestock farming and how they can mitigate the impact of this practice within the One Health framework.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    我们今天的农业食品系统应该为不断增长的人口提供足够的优质健康食品。然而,它还应该保护自然资源,更好地保护牲畜。在这种情况下,一些FoodTech公司正在开发一种颠覆性方法:用于体外食品生产的细胞培养“肉”,但这项技术仍处于研发阶段。本文将重点介绍它的发展,所使用的技术和所涉及的利益相关者(第1部分),其潜在的环境影响(第2部分),还有监管,社会和伦理问题(第3部分)。本文旨在在整个手稿中阐明与“养殖肉”有关的两个主要争议。第一个争议与它的伦理方面有关,其中包括不同的观点:它有可能减少动物的痛苦,从而改善动物的福利,我们社会的未来价值观,以及食品人工化的趋势。第二个争议包括环境,健康和营养问题,关于“养殖肉”的特征和质量,有一个重要的问题:我们应该称之为肉吗?这两个争议与相关社会相互作用,法律问题和政治问题。各种问题的答案取决于利益相关者对世界的不同看法,消费者和公民。他们中的一些人主张适度或强烈减少畜牧业,甚至废除被视为对农场动物的剥削的畜牧业。其他人只是希望减少当前备受批评的密集/工业模式。与其他潜在的可持续解决方案相比,例如减少粮食损失和浪费,动物来源蛋白质减少的新食物消费习惯,可持续集约化,发展农业生态畜牧业生产,或其他肉类替代品市场的发展(来自植物的蛋白质,真菌蛋白,藻类,昆虫,等。),“养殖肉”有一个不确定的未来。
    Our agri-food system today should provide enough healthy food of good quality for the growing human population. However, it should also preserve natural resources and better protect livestock. In this context, some FoodTech companies are developing a disruptive approach: cell culture for in vitro food production of \"meat\" but this technology is still at the research and development stage. This article will highlight its development, the technologies used and the stakeholders involved (Part 1), its potential environmental impacts (Part 2) but also regulatory, social and ethical issues (Part 3). This article aims to shed light throughout the manuscript on two major controversies related to \"cultured meat\". The first controversy is related to its ethical aspects, which includes different points: its potential to reduce animal suffering and therefore to improve animal welfare, the future values of our society, and a trend towards food artificialisation. The second controversy includes environmental, health and nutritional issues, in relation to the characteristics and quality of \"cultured meat\" with an important question: should we call it meat? These two controversies act in interaction in association with related societal, legal and consequently political issues. Answers to the various questions depend on the different visions of the World by stakeholders, consumers and citizens. Some of them argue for a moderate or a strong reduction in livestock farming, or even the abolition of livestock farming perceived as an exploitation of farm animals. Others just want a reduction of the current much criticised intensive/industrial model. Compared with other potential sustainable solutions to be implemented such as reduction of food losses and waste, new food consumption habits with less proteins of animal sources, sustainable intensification, development of agroecological livestock production, or the development of the market for other meat substitutes (proteins from plants, mycoproteins, algae, insects, etc.), \"cultured meat\" has an uncertain future.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Meta-Analysis
    背景:在世界许多地方,考克斯病是一种被忽视的人畜共患病。绵羊和山羊是两种重要的小反刍动物,它们是人类污染的水库;然而,在区域和全球范围内,缺乏有关绵羊和山羊柯克氏病流行病学方面的全面数据。这项研究的目的是系统地回顾有关绵羊和山羊中coxiellosis的血清阳性率的现有文章,并估计不同地区的总体血清阳性率。
    方法:在五个电子存储库中对直到2021年12月发表的文章进行了系统的搜索策略。根据纳入标准从选定的文章中提取相关数据。采用随机效应元分析模型对数据进行分析。结果表示为血清阳性的患病率,以百分比和95%置信区间表示。
    结果:绵羊考氏杆菌病的总体合并血清阳性率为17.38%(95%置信区间[CI]:15.59%-19.17%)。总的来说,绵羊的区域水平汇总患病率估计范围为15.04%(95%CI:7.68%-22.40%)至19.14%(95%CI:15.51%-22.77%),取决于地区。山羊梭菌病的总体合并血清阳性率为22.60%(95%CI:19.54%-25.66%)。总的来说,山羊的区域水平汇总患病率估计范围从6.33%(95%CI:2.96%-9.71%)到55.13%(95%CI:49.61%-60.65%),取决于地区。根据年龄的不同,绵羊和山羊的患病率估计也有很大差异,性别,和动物饲养系统(p<0.001)。
    结论:绵羊和山羊中的coxielis病的血清阳性率相当高。需要对绵羊和山羊种群进行常规监测,以防止其他牲畜和人类的溢出感染。
    Coxiellosis is a neglected zoonosis for occupationally exposed people in many parts of the world. Sheep and goats are two important small ruminants that act as reservoirs for human contamination; however, there is a lack of comprehensive data on the epidemiological aspects of coxiellosis in sheep and goats at regional and global levels. The aim of this study was to systematically review the available articles on seroprevalence of coxiellosis in sheep and goats and estimate the overall seroprevalence in different regions.
    A systematic search strategy was performed in five electronic repositories for articles published until December 2021. Relevant data were extracted from the selected articles based on the inclusion criteria. A random effect meta-analysis model was used to analyse the data. Results are presented as the prevalence of seropositivity as a percentage and 95% confidence intervals.
    The global pooled seroprevalence of coxiellosis in sheep was 17.38% (95% confidence interval [CI]: 15.59%-19.17%). Overall, the regional level pooled prevalence estimates in sheep ranged from 15.04% (95% CI: 7.68%-22.40%) to 19.14% (95% CI: 15.51%-22.77%), depending on region. The global pooled seroprevalence of coxiellosis in goats was 22.60% (95% CI: 19.54%-25.66%). Overall, the regional level pooled prevalence estimates in goats ranged from 6.33% (95% CI: 2.96%-9.71%) to 55.13% (95% CI: 49.61%-60.65%), depending on the region. The prevalence estimates also varied significantly in both sheep and goats depending on age, sex, and rearing systems of the animals (p < 0.001).
    Seroprevalence of coxiellosis in both sheep and goats is considerable. Routine monitoring of the sheep and goat populations is needed to prevent spillover infection in other livestock and humans.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    这篇综述旨在总结有关集约化畜牧业排放的生物气溶胶的环境暴露与生活在畜牧业附近的人们的微生物组变化之间的关系的当前知识状态。PubMed,通过交叉来自以下3组的关键字来搜索Scopus和WebofScience数据库:a)“牲畜,\"\"动物农场,\"\"动物育种\";b)\"微生物组,\"\"抗性组\";c)\"牲畜附近,\"\"农场附近,“社区与健康”在2010-2022年。文献筛选没有发现任何与所研究人群中完整微生物组组成相关的论文。在研究中,作者包括7篇论文(5篇来自荷兰,1来自美国,1来自中国)。研究证实了金黄色葡萄球菌的携带,包括耐甲氧西林金黄色葡萄球菌(MRSA),生活在家畜农场500-2000m内的成人和儿童的鼻腔微生物组中的与MRSA(LA-MRSAMC398)和多药耐药金黄色葡萄球菌(MDRSA)。艰难梭菌,包括LA-robotypeRT078马车,在生活在500-1000m内的成年人的肠道微生物群中检测到。在生活在500-6200m内的成年人的肠道微生物群中证实了产超广谱β-内酰胺酶(ESBL)的肠杆菌科。对生活在家畜农场附近的人们的微生物区系组成的了解不足以得出有关生物气溶胶环境排放引起的微生物组变化的结论。LA细菌的携带患病率,包括具有抗菌素抗性和抗菌素抗性基因的菌株,证实了在没有与动物职业接触的人群中,人畜共患细菌的存在。不能排除人畜共患细菌,作为微生物组的组成部分,对人们的健康有负面影响。IntJOccupMedEnvironHealth。2024;37(2)。
    This review is aimed at summarizing the current state of knowledge about the relationship between environmental exposure to the bioaerosol emitted by intensive livestock farming and changes in the microbiome of people living in livestock farm vicinity. The PubMed, Scopus and Web of Science databases were searched by crossing keywords from the following 3 groups: a) \"livestock,\" \"animal farms,\" \"animal breeding\"; b) \"microbiome,\" \"resistome\"; c) \"livestock vicinity,\" \"farm vicinity,\" \"neighborhoods and health\" in 2010-2022. Literature screening did not reveal any paper related to the full microbiome composition in the population studied. In the study, the authors included 7 papers (5 from the Netherlands, 1 from the USA, and 1 from China). The studies confirmed the carriage of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), livestockassociated MRSA (LA-MRSA MC398) and multidrug-resistant S. aureus (MDRSA) in the nasal microbiome of adults and children living within 500-2000 m from a livestock farm. Clostridium difficile, including LA-ribotype RT078 carriage, was detected in the intestinal microbiome of adults living within 500-1000 m. Extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae were confirmed in the intestinal microbiome of adults living within 500-6200 m. Knowledge on the composition of the microflora of people living in livestock farm vicinity is insufficient to conclude about changes in the microbiome caused by the environmental emission of bioaerosol. The carriage prevalence of the LA-bacteria, including both strains with antimicrobial resistance and antimicrobial resistance genes, confirms the presence of zoonotic bacteria in the human microflora in populations without occupational contact with animals. It cannot be ruled out that zoonotic bacteria, as a component of the microbiome, have a negative impact on people\'s health. Int J Occup Med Environ Health. 2024;37(2):138-52.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    需要更明确地整合社会对畜牧业的期望,这使得本文的作者认为必须重新设计畜牧业系统,将健康和福利置于其目标的核心。本文提出了对不同规模的知识进步的看法,以促进这种转变。在定义了动物的健康和福利之后,这篇文章强调需要从更广泛的角度考虑健康,为了加深关于福利的积极情绪体验的问题,并提出了如何评估农场的这两个要素的问题。提出了健康与福利之间的积极互动。还讨论了它们之间可能存在的一些紧张关系,特别是当通过提供更刺激和更丰富的环境来改善福利时,例如进入户外,会增加传染病的风险。共同改善动物的健康和福利提出了许多不同规模的问题,从动物层面到生产链。在动物层面,作者强调需要探索:更好的福利和生理平衡之间的长期联系,微生物群的作用,将积极的精神状态和健康联系起来的心理-神经-内分泌机制,以及生产的生理功能之间的权衡,繁殖和免疫。在农场一级,除了在团体层面研究福利之间的关系,健康和生产,本文支持与畜牧业农民共同构建创新系统的想法,以及分析成本,改进系统对其工作条件和福祉的可接受性和影响。在生产链或地区层面,提出了各种问题。这些措施包括研究改善动物健康和福利的最佳策略,同时保持经济可行性。产品的标签和消费者的支付意愿,动物性状的异质性对动物产品加工的影响,以及畜牧业的空间分布以及生产和价值链的组织。在公民和消费者层面,挑战之一是一方面更好地相互关联的卫生和健康观点,另一方面,福利问题。还需要提高公民对畜牧业的知识,发展畜牧业农民之间更激烈和建设性的交流,畜牧业和公民。这些棘手的问题恳求跨学科和跨学科研究涉及各种科学学科和不同的利益相关者,包括通过参与式研究的公共政策制定者。
    The need to integrate more clearly societal expectations on livestock farming has led the authors of this article to consider that livestock farming systems must be redesigned to position health and welfare at the heart of their objectives. This article proposes a vision of the advances in knowledge required at different scales to contribute to this transformation. After defining health and welfare of animals, the article emphasises the need to consider health in a broader perspective, to deepen the question of positive emotional experiences regarding welfare, and raises the question of how to assess these two elements on farms. The positive interactions between health and welfare are presented. Some possible tensions between them are also discussed, in particular when improving welfare by providing a more stimulating and richer environment such as access to outdoor increases the risk of infectious diseases. Jointly improving health and welfare of animals poses a number of questions at various scales, from the animal level to the production chain. At the animal level, the authors highlight the need to explore: the long-term links between better welfare and physiological balance, the role of microbiota, the psycho-neuro-endocrine mechanisms linking positive mental state and health, and the trade-off between the physiological functions of production, reproduction and immunity. At the farm level, in addition to studying the relationships at the group level between welfare, health and production, the paper supports the idea of co-constructing innovative systems with livestock farmers, as well as analysing the cost, acceptability and impact of improved systems on their working conditions and well-being. At the production chain or territory levels, various questions are raised. These include studying the best strategies to improve animal health and welfare while preserving economic viability, the labelling of products and the consumers\' willingness to pay, the consequences of heterogeneity in animal traits on the processing of animal products, and the spatial distribution of livestock farming and the organisation of the production and value chain. At the level of the citizen and consumer, one of the challenges is to better inter-relate sanitary and health perspectives on the one hand, and welfare concerns on the other hand. There is also a need to improve citizens\' knowledge on livestock farming, and to develop more intense and constructive exchanges between livestock farmers, the livestock industry and citizens. These difficult issues plead for interdisciplinary and transdisciplinary research involving various scientific disciplines and the different stakeholders, including public policy makers through participatory research.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    戊型肝炎病毒(HEV)是重要的公共卫生问题,是急性和慢性病毒性肝炎的原因。HEV的公共卫生影响来自其传播途径,水性或食源性,以及它的人畜共患潜力。不仅在发展中国家,但是在发达国家,HEV病例也很高。HEV向环境的扩散可能会污染地表水,这可能是人类和动物的感染源。动物产品中病毒的鉴定表明HEV在水和食物链中的循环。牲畜中HEV的高血清阳性率和循环,尤其是猪,以及在环境样本中,需要进一步调查生猪市场。不同环境和肉类供应链中的HEV毒力可以揭示人类可能的感染源和职业风险程度。这篇综述的目的是讨论HEV感染,重点是与生活和环境相关的危险因素,和食源性,水性,和人畜共患传播。
    Hepatitis E virus (HEV) is an important public health problem and is responsible for both acute and chronic viral hepatitis. Public health implications of HEV are derived from its transmission route, either water-borne or food-borne, and its zoonotic potential. Not only in developing countries, but HEV cases are also found in a high number in developed countries. The spread of HEV to the environment might pollute surface waters, which could act as the source of infection for both humans and animals. Identification of the virus in animal products suggests the circulation of HEV within water and food chains. High seroprevalence and circulation of HEV in livestock, in particular pigs, as well as in environmental samples warrants further investigation into pig markets. HEV virulence in different environments and meat supply chains could shed light on the possible sources of infection in humans and the degree of occupational risk. The purpose of this review is to discuss HEV infections with an emphasis on livestock- and environment-related risk factors, and food-borne, water-borne, and zoonotic transmissions.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    这篇全面的综述严格审查了蛋白质组学在理解家畜动物精子冷冻损伤机制中的应用。在广泛使用精液冷冻保存进行遗传保护的背景下。尽管它被全球采用,由于冷冻损伤,冷冻保存通常会对精子质量和生育能力产生不利影响。这些伤害主要来自于冰晶的形成,渗透变化,氧化应激,以及冷冻和解冻过程中膜蛋白和脂质的重组,导致过早的类似获能的变化。此外,冷冻保存过程诱导哺乳动物精子蛋白质组重塑。虽然精液冷冻保存技术有了进步,哺乳动物精子冷冻损伤的确切机制仍然难以捉摸。这篇综述提供了对蛋白质组学技术的最新进展如何对这些分子破坏进行详细研究的深入探索。它提供了解冻后蛋白质水平变化的分析及其对精子活力和功能的影响。此外,它讨论了蛋白质组学在改进冷冻保存技术以减轻冷冻损伤和提高家畜繁殖结果中的作用。这项工作综合了当前的知识,突出差距,并为动物生殖科学和生物技术的未来研究提出了方向。
    This comprehensive review critically examines the application of proteomics in understanding sperm cryoinjury mechanisms in livestock animals, in the context of the widespread use of semen cryopreservation for genetic conservation. Despite its global adoption, cryopreservation often detrimentally affects sperm quality and fertility due to cryoinjuries. These injuries primarily arise from ice crystal formation, osmotic shifts, oxidative stress, and the reorganization of membrane proteins and lipids during freezing and thawing, leading to premature capacitation-like changes. Moreover, the cryopreservation process induces proteome remodeling in mammalian sperm. Although there have been technological advances in semen cryopreservation, the precise mechanisms of mammalian sperm cryoinjury remain elusive. This review offers an in-depth exploration of how recent advancements in proteomic technologies have enabled a detailed investigation into these molecular disruptions. It presents an analysis of protein-level alterations post-thaw and their impact on sperm viability and functionality. Additionally, it discusses the role of proteomics in refining cryopreservation techniques to mitigate cryoinjury and enhance reproductive outcomes in livestock. This work synthesizes current knowledge, highlights gaps, and suggests directions for future research in animal reproductive science and biotechnology.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号