背景:在调查对光的非视觉反应的研究中,报告光特征没有共识。该项目旨在为基于实验室的调查制定报告清单,以研究光线对非视觉生理学的影响。
方法:进行了国际专家参与的四步改进的Delphi过程(三轮基于问卷的反馈和一次面对面的小组讨论),以就清单中的项目达成共识。在达成共识之后,由此产生的清单在试点阶段由独立专家进行了测试。
结果:与报告基于光的干预措施有关的61个项目的初始列表浓缩为包含25个项目的最终清单,基于专家的共识(最终n=60)。无论研究问题或背景如何,都认为有九个项目需要报告。每个项目的描述在随附的解释和详细说明(E&E)文档中提供。独立的试点测试阶段导致检查表和E&E文档中的少量文字说明。
结论:ENLIGHT清单是第一个基于共识的清单,用于记录和报告人类研究中基于眼部光线的干预措施。核对表的实施将通过确保全面的文件,增强基于光的研究的影响,增强再现性,并实现跨研究的数据聚合。
背景:欧洲高级研究所(NETIAS)建设性高级思维(CAT)计划网络;亨利·惠康爵士博士后奖学金(惠康信托,204686/Z/16/Z);荷兰卫生研究与发展组织VENI研究金(2020-09150161910128);美国国防部赠款(W81XWH-16-1-0223);新加坡国立大学(NUHSRO/2022/038/Startup/08);和新加坡国家研究基金会(NRF2022-THE004-0002)。
BACKGROUND: There is no
consensus on reporting
light characteristics in studies investigating non-visual responses to
light. This project aimed to develop a reporting checklist for laboratory-based investigations on the impact of light on non-visual physiology.
METHODS: A four-step modified Delphi process (three questionnaire-based feedback rounds and one face-to-face group discussion) involving international experts was conducted to reach consensus on the items to be included in the checklist. Following the
consensus process, the resulting checklist was tested in a pilot phase with independent experts.
RESULTS: An initial list of 61 items related to reporting light-based interventions was condensed to a final checklist containing 25 items, based upon
consensus among experts (final n = 60). Nine items were deemed necessary to report regardless of research question or context. A description of each item is provided in the accompanying Explanation and Elaboration (E&E) document. The independent pilot testing phase led to minor textual clarifications in the checklist and E&E document.
CONCLUSIONS: The ENLIGHT Checklist is the first consensus-based checklist for documenting and reporting ocular
light-based interventions for human studies. The implementation of the checklist will enhance the impact of light-based research by ensuring comprehensive documentation, enhancing reproducibility, and enabling data aggregation across studies.
BACKGROUND: Network of European Institutes for Advanced Study (NETIAS) Constructive Advanced Thinking (CAT) programme; Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust, 204686/Z/16/Z); Netherlands Organisation for Health Research and Development VENI fellowship (2020-09150161910128); U.S. Department of Defense Grant (W81XWH-16-1-0223); National University of Singapore (NUHSRO/2022/038/Startup/08); and National Research Foundation Singapore (NRF2022-THE004-0002).