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Abstract：
The aim of this study was to investigate retinal and peripheral microvascular function in asymptomatic individuals that fall into different BP groups when using either the ESC/ESH or the ACC/AHA guidelines. Retinal and peripheral microvascular function was assessed in 358 participants by means of dynamic retinal vessel analysis and digital thermal monitoring, respectively. Blood pressure and lipid panel were also evaluated. Retinal vascular function measured in all groups belonging to the ACC/ASH classifications were within the normal values for age-matched normal population. Individuals classed as grade 1 hypertension according to the ESC/ESH guidelines, however, exhibited a significantly decreased artery baseline (p = 0.0004) and MC (p = 0.040), higher slopeAD (p = 0.0018) and decreased vein MC (p = 0.0446) compared to age matched normal individuals. In addition, they also had significant lower artery baseline, artery BDF, MD and MC than individuals classed as stage 1 hypertension based on the ACC/ASH guidelines (p = 0.00022, p = 0.0179, p = 0.0409 and p = 0.0329 respectively). Peripheral vascular reactivity (aTR) was lower in ESC /ESH grade I compared to those graded ACC/ASH stage I hypertension (p = 0.0122). The conclusion of this study is that microvascular dysfunctions is present at multiple levels only in individuals with ESC/ESH grade 1 hypertension. This observation could be important when deciding personalised care in individuals with early hypertensive changes.
摘要：
这项研究的目的是调查使用ESC/ESH或ACC/AHA指南时属于不同BP组的无症状个体的视网膜和周围微血管功能。通过动态视网膜血管分析和数字热监测评估358名参与者的视网膜和周围微血管功能。分别。还评估了血压和血脂组。在属于ACC/ASH分类的所有组中测量的视网膜血管功能在年龄匹配的正常人群的正常值内。根据ESC/ESH指南，被归类为1级高血压的个体，然而,表现出显著降低的动脉基线（p=0.0004）和MC（p=0.040），与年龄匹配的正常人相比，slopeAD较高（p=0.0018）和静脉MC降低（p=0.0446）。此外,他们也有明显的下动脉基线，动脉BDF,根据ACC/ASH指南，MD和MC比个体归类为1期高血压（分别为p=0.00022，p=0.0179，p=0.0409和p=0.0329）。与分级的ACC/ASHI期高血压相比，ESC/ESHI级的外周血管反应性（aTR）较低（p=0.0122）。这项研究的结论是，微血管功能障碍仅在ESC/ESH1级高血压患者中存在多个水平。在确定患有早期高血压变化的个体的个性化护理时，此观察结果可能很重要。
