■已经提出乳腺癌干细胞(BCSC)负责乳腺癌(BC)的发展。本研究的目的是评估BCSCs和靶器官微环境免疫表型标志物在常见BC转移中的作用。和关于上述标准的治疗目标。
■此叙述性审查涉及搜索国际数据库;PubMed,谷歌学者使用预先确定的关键词,包括乳腺癌,乳腺癌干细胞,乳腺癌转移,免疫表型,免疫组织化学和转移。搜索结果是根据标题进行评估的,abstract,和文章全文,和相关的调查结果被纳入审查。
■BCSC表达大量的醛脱氢酶1(ALDH1),神经节苷脂2(GD2),CD44和CD133,但CD24标记阴性。CXCR4和OPN在细胞中高表达,可能有助于BC向骨骼的转移。Nestin,已报道BCSC中的CK5、显著蛋白-1(CD133)标志物与脑转移相关。CD44在BCSCs中的高表达和CXCL12在肝脏微环境中的表达可能有助于BC向肝脏的转移。异常表达的血管细胞粘附分子-1(VCAM-1)与肺实质上的胶原蛋白和弹性蛋白纤维结合,肺微环境中BCSCs的CXCR4和CXCL12可能促进细胞归巢和转移到肺。
■在各种类型的BC转移中,由细胞和靶器官微环境表达的不同标志物负责,BCSCs免疫分型可作为预测疾病预后和治疗的靶标志物。
UNASSIGNED: Breast cancer stem cells (BCSCs) have been suggested to be responsible for the development of Breast cancer (BC). The aim of this study was to evaluate BCSCs and the target organs microenvironment
immunophenotyping markers in common BC metastases, and therapeutic targets regarding to the mentioned criteria.
UNASSIGNED: This narrative
review involved searching international databases; PubMed, Google Scholar using predetermined keywords including breast cancer, breast cancer stem cells, breast cancer metastases,
immunophenotyping, immunohistochemistry and metastases. The search results were assessed based on the title, abstract, and full text of the articles, and relevant findings were included in the
review.
UNASSIGNED: BCSCs express high amounts of aldehyde dehydrogenase 1 (ALDH1), Ganglioside 2 (GD2), CD44 and CD133 but are negative for CD24 marker. CXCR4 and OPN have high expression in the cells and may contribute in BC metastasis to the bone. Nestin, CK5, prominin-1 (CD133) markers in BCSCs have been reported to correlate with brain metastasis. High expression of CD44 in BCSCs and CXCL12 expression in the liver microenvironment may contribute to BC metastasis to the liver. Aberrantly expressed vascular cell adhesion molecule-1 (VCAM-1) that binds to collagen and elastin fibers on pulmonary parenchyma, and CXCR4 of BCSCs and CXCL12 in lung microenvironment may promote the cells homing and metastasis to lung.
UNASSIGNED: As in various types of BC metastases different markers that expressed by the cells and target organ microenvironment are responsible, BCSCs
immunophenotyping can be used as target markers to predict the disease prognosis and treatment.