Abstract：
Interfollicular Hodgkin lymphoma (IHL) has been rarely reported in the literature and is recognized by the WHO Classification as a morphologic pattern sometimes seen in mixed cellularity classic Hodgkin lymphoma (CHL). The changes may be subtle due to preservation of architecture. We report a case of a 9-year-old male with IHL showing preserved follicular architecture but with the presence of interfollicular infiltrates consisting of eosinophils, plasma cells, and Hodgkin-Reed-Sternberg (HRS) cells. Immunophenotyping confirmed the morphologic suspicion for IHL. A discussion and review of the literature are offered. We conclude that IHL is a variant that requires a high index of suspicion, as it may be easily missed due to the subtle morphologic features and preserved architecture seen in most cases. We further emphasize that unexplained interfollicular infiltrates of eosinophils may be clues that should prompt a search of HRS cells and consideration of immunohistochemical staining if needed.
摘要：
滤泡间霍奇金淋巴瘤（IHL）在文献中很少报道，并且被WHO分类认可为有时在混合细胞性经典霍奇金淋巴瘤（CHL）中可见的形态学模式。由于保留了建筑，这些变化可能是微妙的。我们报告了一例9岁男性，IHL显示保留的卵泡结构，但存在由嗜酸性粒细胞组成的卵泡间浸润，浆细胞,和霍奇金-里德-斯特恩伯格(HRS)细胞。免疫表型证实了IHL的形态学怀疑。对文献进行了讨论和回顾。我们得出的结论是，国际人道主义法是一种需要高度怀疑的变体，因为在大多数情况下，由于微妙的形态特征和保留的体系结构，它可能很容易被错过。我们进一步强调，无法解释的嗜酸性粒细胞滤泡间浸润可能是提示搜索HRS细胞并在需要时考虑免疫组织化学染色的线索。
