目的:介绍了希腊首例Legg-Calvé-Perthes病(LCPD)。LCPD,一种罕见的疾病,使用古代罕见疾病数字地图集(DAARD)进行讨论,通过DAARD中记录的42例LCPD考古病例,测试了数据库对新病例的诊断和背景化的好处。
方法:30-40岁,在奥林匹亚的考古现场发现了可能的男性个体,希腊,约会到500-700CE。
方法:生物性别,使用宏观和骨测量方法研究了死亡年龄和病理变化。DAARD提供了LCPD的典型特征。
结果:两个髋关节的病理变化没有任何其他相关的骨骼变化,与LCPD的骨骼特征相对应。DAARD产生了42例LCPD,其中大部分来自欧洲,偏爱男性和单侧参与髋关节。
结论:在已知研究的背景下,DAARD有助于诊断罕见疾病和解释新病例。
结论:这项研究表明,DAARD有可能帮助研究人员超越单一案例研究的水平,并为罕见疾病的历史创造更广阔的图景。
结论:本文重点关注DAARD与LCPD相关的益处,但并非所有罕见疾病都包含在数据库中。
■应将更多来自考古背景的罕见疾病添加到DAARD中,以创建解释其历史的基础,并扩大我们对过去罕见疾病的理解。
OBJECTIVE: The first
case of Legg-Calvé-Perthes disease (LCPD) in Greece is presented. LCPD, a rare disease, is discussed using the Digital Atlas of Ancient Rare Diseases (DAARD), which tests the benefits of the database for diagnosing and contextualizing the new
case with 42 archaeological cases of LCPD recorded in the DAARD.
METHODS: A 30-40-year-old, probable male individual was found at the archaeological site of Olympia, Greece, dating to 500-700 CE.
METHODS: Biological sex, age-at-death and pathological changes were investigated using macroscopic and osteometric methods. The DAARD provided the typical characteristics of LCPD.
RESULTS: Pathological changes in both hip joints without any other related changes in the skeleton corresponded to the skeletal features of LCPD. The DAARD produced 42 cases of LCPD, most of which from Europe, with a preference for male sex and unilateral involvement of the hip joint.
CONCLUSIONS: The DAARD aids in diagnosing rare diseases and interpreting new cases in the context of already known studies.
CONCLUSIONS: This study shows that the DAARD has the potential to help researchers move beyond the level of single
case studies and create a broader picture of the history of rare diseases.
CONCLUSIONS: This paper focuses on the benefits of the DAARD in relation to LCPD but not all rare diseases have been included in the database.
UNASSIGNED: More rare diseases from archaeological contexts should be added to the DAARD to create a base for the interpretation of their history and expand our understanding of rare diseases in the past.