背景:乳腺癌是一个总称,是指一组源自乳房的生物学和分子异质性疾病。全球范围内,在过去的几十年中,乳腺癌的发病率急剧增加。对多个临床“大数据”的分析可以帮助我们阐明预防这种疾病的方法。此外,如果我们能够确认它们的相关性,诱发风险因素将是最重要的问题。这项研究旨在概述导致患乳腺癌的可能性更高的诱发因素,并强调我们应该更加关注的迹象。
方法:这是一项匹配的巢式病例对照研究。该队列的重点是根据批准的协议,通过台湾国家健康保险研究数据库(NHIRD)中的数据筛选(2000-2013年)来确定乳腺癌发展中的合格危险因素。从全国抽样数据库中登记了486,069名女性,3281名女性作为乳腺癌队列,从2000年到2013年从未诊断出乳腺癌的478,574名女性有资格作为非乳腺癌对照。并根据年龄使用1:6的比例与乳腺癌病例相匹配。
结果:我们对3281例乳腺癌病例和19686例非乳腺癌对照患者进行了年龄匹配的分析。与乳腺癌发展相关的重要诱发因素包括肥胖,高脂血症,甲状腺癌和肝癌。对于55岁以下的患者,胃癌似乎确实对乳腺癌的发展产生影响;与55岁以上的患者相比,子宫内膜癌似乎表现出唤起作用。
结论:在这项全国匹配的巢式病例对照研究中,我们确定了肥胖,高脂血症,以前的甲状腺癌,胃和肝脏是与乳腺癌相关的危险因素。然而,某些癌症的回顾性性质和有限的病例数仍然难以提供有力的证据.需要进一步的前瞻性研究来证实这一发现,以便将疾病扼杀在萌芽状态。
背景:涉及人类参与者的研究由中国医科大学附属医院[CMUH104-REC2-115(AR-4)]审查并批准。
BACKGROUND: Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically over the past decades. Analyses of multiple clinical \"big data\" can aid us in clarifying the means of preventing the disease. In addition, predisposing risk factors will be the most important issues if we can confirm their relevance. This study aims to provide an overview of the predisposing factors that contribute to a higher possibility of developing breast cancer and emphasize the signs that we ought to pay more attention to.
METHODS: This is a matched nested
case-control study. The cohort focused on identifying the eligible risk factors in breast cancer development by data screening (2000-2013) from the Taiwan National Health Insurance Research Database (NHIRD) under approved protocol. A total of 486,069 females were enrolled from a nationwide sampled database, and 3281 females was elligible as breast cancer cohort, 478,574 females who had never diagnosed with breast cancer from 2000 to 2013 were eligible as non-breast cancer controls, and matched to breast cancer cases according to age using a 1:6 ratio.
RESULTS: We analyzed 3281 breast cancer cases and 19,686 non-breast cancer controls after an age-matched procedure. The significant predisposing factors associated with breast cancer development including obesity, hyperlipidemia, thyroid cancer and liver cancer. As for patients under the age of 55, gastric cancer does seem to have an impact on the development of breast cancer; compared with their counterparts over the age of 55, endometrial cancer appears to exhibit an evocative effect.
CONCLUSIONS: In this nationwide matched nested
case-control study, we identified obesity, hyperlipidemia, previous cancers of the thyroid, stomach and liver as risk factors associated with breast cancer. However, the retrospective nature and limited
case numbers of certain cancers still difficult to provide robust evidence. Further prospective studies are necessitated to corroborate this finding in order to nip the disease in the bud.
BACKGROUND: The studies involving human participants were reviewed and approved by the China Medical University Hospital [CMUH104-REC2-115(AR-4)].