目前,化学性结肠炎在临床上主要是由医源性因素引起的。消毒剂戊二醛是可引起化学性结肠炎的常见药物之一,但是关于它的报道很少。2019年8月至2022年8月,在浙江大学医学院附属第二医院和松阳县人民医院内镜室进行了1457例结肠镜检查,本报告讨论了3例戊二醛残留引起的化学性结肠炎。所有3例病例均发生在同一内窥镜系统和同一天。这3名患者住院并接受肠道休息治疗,水合作用,经口康复新液,地塞米松联合康复新液局部灌肠治疗,和经验性抗生素。总之,加强小肠镜检查科室的清洁消毒规范化管理,特别是那些使用浓缩戊二醛浸渍溶液并在浸渍后清洗的产品,预防与消毒剂有关的急性化学性肠炎的发生。
Currently, chemical colitis in clinical practice is mainly caused by iatrogenic factors. The disinfectant
glutaraldehyde is one of the common drugs that can cause chemical colitis, but there are few
reports about it. From August 2019 to August 2022, 1457 cases of colonoscopy were performed in the endoscopy room of the Second Affiliated Hospital of Zhejiang University School of Medicine and Songyang County People\'s Hospital, and 3 cases of chemical colitis caused by
glutaraldehyde residue are discussed in this report. All 3 cases occurred on the same endoscopic system and same day. These 3 patients were hospitalized and treated with bowel rest, hydration, peroral Kangfuxin solution, dexamethasone combined with Kangfuxin solution local enema treatment, and empiric antibiotic. In conclusion, standardized management of cleaning and disinfection should be strengthened in departments carrying out enteroscopy, especially those using the concentrated
glutaraldehyde immersion solution and cleaning after immersion, to prevent the occurrence of acute chemical enteritis related to disinfectant.