吸入剂如一氧化二氮(N2O)的滥用,在全球范围内随时可用,在过去的几十年中,一直是一个突出的公共卫生问题。文献显示,在上一次大流行期间,使用增加,特别是关于娱乐用途。现有的基于证据的数据有限,无法将N2O的滥用与精神病联系起来。因此,这个病例报告了一个22岁的成年人,以前没有精神病史,据报道,在上一次大流行的COVID-19封锁期间,每天滥用75-100罐N2O,强调了(N2O)滥用与包括妄想在内的症状之间的关系,幻听,和杂乱无章的认知。所有实验室发现和影像学检查的结果均与症状的任何有机原因不一致。然后,该病例接受了抗精神病药物和多学科模型的治疗,逐渐改善症状。案件,特别是,讨论N2O滥用,这在欧盟国家很普遍,包括英国和爱尔兰共和国,它的长期使用会使人患精神病的风险更高,人格改变,情感上的不稳定,焦虑,抑郁症,认知障碍,和脊髓神经病。许多国家禁止出售N2O的精神活性物质,包括爱尔兰共和国,根据立法。然而,N2O不是受控药物,这意味着拥有N2O不是犯罪。此病例报告显示了滥用N2O引起的精神病,这将进一步吸引该领域的专家进行流行病学研究,以在基层进行预防。
The abuse of inhalants like nitrous oxide (N2O), readily available worldwide, has remained a prominent public health problem during the last few decades. Literature reveals increased use during the previous pandemic, particularly regarding recreational use. There is limited evidence-based data available to relate the abuse of N2O with psychosis. Therefore, this
case report of a 22-year-old adult with no previous psychiatry history, reportedly abusing 75-100 canisters of N2O per day during the last pandemic COVID-19 lockdown, highlights the relationship between (N2O) abuse and the symptoms evolved including delusions, auditory hallucinations, and disorganized cognition. All the laboratory findings and results from imaging modalities were inconsistent for any organic cause of the symptoms. The
case then underwent treatment with antipsychotic medications and a multidisciplinary model, which improved the symptoms gradually. The
case, in particular, discusses N2O abuse, which is widespread in European Union countries, including the UK and the Republic of Ireland, and its chronic use puts one at a higher risk of developing psychosis, personality changes, affective lability, anxiety, depression, cognitive impairment, and myeloneuropathy. The sale of N2O for its psychoactive properties is prohibited in many countries, including the Republic of Ireland, as per legislation. However, N2O is not a controlled drug, meaning it is not a crime to possess N2O. This
case report manifests the psychopathy caused by abuse of N2O, which would further attract specialists in the field to conduct epidemiological studies for prevention at the primary level.