未经证实:小儿炎症性多系统综合征(PIMS)是儿童严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)感染的并发症,类似于川崎综合征,使他们处于心肺不稳定和/或心脏损害的高风险中。本研究旨在描述墨西哥城PIMS患者的临床表现和结果。
UNASSIGNED:这是一项基于疾病控制和预防中心病例定义标准的PIMS住院儿童的观察性研究,2020年5月1日至2021年9月30日在墨西哥城的一家三级儿科中心。人口特征,流行病学数据,病史,实验室测试,心脏病学评估,治疗,并对临床结局进行分析。
UNASIGNED:75例符合PIMS的病例定义标准[中位年龄:10.9岁,四分位数间距(IQR):5.6-15.6]。15例(20%)患者患有严重的基础疾病,48人(64%)被送进重症监护室,33(44%)需要有创机械通气,39(52%)接受了血管加压药支持。根据确定的症状,通过潜在类别分析对患者进行聚类:第1组出现皮疹或胃肠道症状(n=60),第2组主要表现为呼吸道症状(n=15)。两名患者(2.7%)死亡,两者都有严重的潜在条件。5名患者(6.7%),全部来自第1组,发展为冠状动脉瘤。
UNASSIGNED:在我们的研究中,严重呼吸道受累和RT-PCR阳性的SARS-CoV-2患者比例很高,冠状动脉瘤病例很少,这表明很高比例的儿童患有严重急性COVID-19。临床表现和结果与以前报道的国际研究相当。
UNASSIGNED: Pediatric inflammatory multisystem syndrome (PIMS) is a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that resembles Kawasaki syndrome and places them at high risk of cardiorespiratory instability and/or cardiac damage. This study aims to describe the clinical presentation and outcomes of patients with PIMS in Mexico City.
UNASSIGNED: This was an observational study of children hospitalized for PIMS based on the Centers for Disease Control and Prevention case definition criteria, in a single tertiary care pediatric center in Mexico City between May 1, 2020, and September 30, 2021. Demographic characteristics, epidemiological data, medical history, laboratory tests, cardiologic evaluations, treatment, and clinical outcomes were analyzed.
UNASSIGNED: Seventy-five cases fulfilled the case definition criteria for PIMS [median age: 10.9 years, Interquartile range (IQR): 5.6-15.6]. Fifteen (20%) patients had a severe underlying disease, 48 (64%) were admitted to the intensive care unit, 33 (44%) required invasive mechanical ventilation and 39 (52%) received vasopressor support. The patients were clustered through latent class analysis based on identified symptoms: Cluster 1 had rash or gastrointestinal symptoms (n = 60) and cluster 2 were those with predominantly respiratory manifestations (n = 15). Two patients (2.7%) died, and both had severe underlying conditions. Five patients (6.7%), all from cluster 1, developed coronary aneurysms.
UNASSIGNED: There were a high proportion of patients with severe respiratory involvement and positive RT-PCR SARS-CoV-2 and very few cases of coronary aneurysms in our study which suggests that a high proportion of the children had severe acute COVID-19. The clinical manifestations and outcomes are comparable to previously reported international studies.