Abstract：
Multisystem Inflammatory Syndrome in Children (MIS-C), a post infectious complication of SARS CoV-2 infection, shares enough features with Kawasaki Disease (KD) that some have hypothesized cross-coronavirus (CoV) immunity may explain the shared pathology. Recent studies have shown that humoral cross-reactivity of the CoVs, particularly of OC43, is focused on the S2 region of the Spike protein. Due to efforts utilizing CoV S2 regions to produce a cross-CoV vaccine, we wished to assess SARS-CoV-2 S2 reactivity in children with KD and assess if cardiac involvement in KD correlated with S2 CoV antibody targeting. The presence of cross-reactivity does not distinguish KD from febrile controls and does not correlate with cardiac involvement in KD. These findings support that, in relation to cardiac vascular inflammation, vaccines targeting the S2 region appear to be a safe approach, but there is disparity in the ability of CoV species to raise cross-reactive S2 targeted antibodies.
摘要：
儿童多系统炎症综合征（MIS-C）SARSCoV-2感染的感染后并发症，与川崎病（KD）有足够的共同特征，有些人假设交叉冠状病毒（CoV）免疫力可以解释共同的病理学。最近的研究表明，CoV的体液交叉反应，特别是OC43，集中在Spike蛋白的S2区域。由于努力利用CoVS2区域生产跨CoV疫苗，我们希望评估KD患儿的SARS-CoV-2S2反应性,并评估KD的心脏受累是否与S2CoV抗体靶向相关.交叉反应性的存在不能将KD与发热对照区分开来，也与KD的心脏受累无关。这些发现支持，与心血管炎症有关，针对S2区域的疫苗似乎是一种安全的方法，但是CoV物种产生交叉反应性S2靶向抗体的能力存在差异。
