目的:为了验证肾皮质和肾髓质之间的计算机断层扫描多相值比,它可用于简明地评估肾移植受者的肾功能。
方法:根据肾脏疾病流行病学合作编年史(eGFR(CKD-EPI))和肾脏疾病饮食模块(eGFR(MDD)),将58例肾脏受者分为正常组(eGFR≥90mL/min/1.73m2)和异常组(eGFR<90mL/min/1.73m2)。动脉期和静脉期肾皮质和髓质的多相比分别为A(RatioC/M)和V(RatioC/M),两者的差值记为D(RatioC/M)。相关/回归分析,学生t检验,和ROC曲线分析用于测试多相比率评估肾功能的能力。
结果:A(比率C/M)和V(比率C/M)均与eGFR(CKD-EPI)中度相关(Y=20.41*X28.20,r=0.40(95%Cl,0.13-0.58),P<0.01;Y=-16.57*X+109.8,r=-0.29(95%Cl,-0.51--0.04),P=0.03)和eGFR(MDRD)(Y=23.72*X+23.52,r=0.38(95%Cl,0.13-0.58),P<0.01;Y=-19.88*X+119.5,r=-0.30(95%Cl,-0.52--0.05),P=0.02)。然而,D(RatioC/M)与eGFR(CKD-EPI)(Y=30.95*X60.71,r=0.61(95%Cl,0.42-0.75),P<0.001)和eGFR(MDRD)(Y=36.47*X+61.01,r=0.62(95%Cl,0.44-0.76),P<0.001),分别,两条回归线无显著差异(斜率:P=0.496,截距:P=0.378)。两组D(RatioC/M)比较差异均有统计学意义(均P<0.05)。ROC曲线分析提供了用于评估eGFR的D(比率C/M)的截断值(AUC:0.863和AUC:0.822,所有P<0.001)。
结论:D(比率C/M)可用于评估肾移植受者的肾功能。
OBJECTIVE: To verify the multiphase ratio of Computer Tomography-value between the renal cortex and renal medulla, which can be used to concisely evaluate renal function in kidney recipients.
METHODS: Fifty-eight kidney recipients were retrospectively enrolled and divided into the Normal group(eGFR≥90 mL/min/1.73m2) and Abnormal group(eGFR<90 mL/min/1.73m2) according to Chronicle Kidney Disease Epidemiology Collaboration (eGFR(CKD-EPI)) and the Modular of Diet in Renal Disease (eGFR(MDRD)) formulas respectively. The multiphasic ratios between the renal cortex and medulla in the arterial phase and venous phase were noted as A(RatioC/M) and V(RatioC/M), and the difference between those two was recorded as D(RatioC/M). Correlation/regression analysis, student t-test, and ROC curves analysis were used to test the ability of multiphasic ratios to assess renal function.
RESULTS: Both A(RatioC/M) and V(RatioC/M) were moderately correlated with eGFR(CKD-EPI) (Y =20.41*X + 28.20, r=0.40 (95%Cl, 0.13-0.58), P<0.01; Y =-16.57*X + 109.8, r=-0.29 (95%Cl, -0.51--0.04), P=0.03) and eGFR(MDRD) (Y =23.72*X + 23.52, r=0.38 (95%Cl, 0.13-0.58), P<0.01; Y =-19.88*X + 119.5, r=-0.30 (95%Cl, -0.52--0.05), P=0.02). However, D(RatioC/M) was strongly positive correlated with eGFR(CKD-EPI) (Y = 30.95*X + 60.71, r=0.61 (95%Cl,0.42-0.75), P<0.001) and eGFR(MDRD) (Y = 36.47*X + 61.01, r=0.62 (95%Cl, 0.44-0.76), P<0.001), respectively, and both regression lines were not significant different (slope: P=0.496, intercept: P=0.378). The differences in D(RatioC/M) between the two groups were significant (all P<0.05). The ROC curve analysis provided the cutoff values of D(RatioC/M) for assessing eGFR (AUC:0.863 and AUC:0.822, all P<0.001).
CONCLUSIONS: The D(RatioC/M) can be used to assess renal function for kidney recipients.