磨牙门牙矿化不足(MIH)是一种非常普遍的牙齿发育障碍,对患者的健康负担很大,治疗需求也很高。然而,尚未发表关于所有再矿化系统作为MIH非侵入性治疗方法的全面综述文章.与健康牙齿相比,受MIH影响的牙齿的典型特征是较低的矿物质密度和较低的硬度,从而导致敏感性和功能丧失。因此,使用含有磷酸钙的配方来补充受MIH影响的牙齿是合理的。这篇综述介绍了再矿化研究的最新概述,重点是研究用于再矿化MIH的活性成分,即,酪蛋白磷酸肽无定形磷酸钙(CPP-ACP),酪蛋白磷酸肽无定形氟化钙磷酸盐(CPP-ACFP),羟基磷灰石,甘油磷酸钙,自组装肽,和氟化物。总的来说,19项研究(体外,在原地,和体内)被发现。此外,一项针对使用牙膏/洁齿剂进行MIH管理的研究的额外搜索导致了六项研究,其中三项研究是关于再矿化的,三项是关于敏感性降低的。总的来说,这篇综述中分析的研究表明,使用基于磷酸钙的方法可以再矿化受MIH影响的牙齿.总之,磷酸钙如CPP-ACP,甘油磷酸钙,和羟基磷灰石可用于再矿化受MIH影响的牙齿。除了MIH再矿化,CPP-ACP和羟基磷灰石也减轻了MIH相关的牙齿敏感性。
Molar incisor hypomineralization (MIH) is a highly prevalent dental developmental disorder with a significant health burden for patients and high treatment needs, yet no comprehensive
review article on all remineralization systems as a non-invasive treatment approach for MIH has been published. Typical characteristics of MIH-affected teeth are a lower mineral density and lower hardness compared to healthy teeth leading to sensitivity and loss of function. Thus, the use of formulations with calcium phosphates to remineralize MIH-affected teeth is reasonable. This
review presents an up-to-date overview of remineralization studies focusing on active ingredients investigated for remineralization of MIH, i.e., casein phosphopeptide amorphous calcium phosphate (CPP-ACP), casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP), hydroxyapatite, calcium glycerophosphate, self-assembling peptide, and fluoride. Overall, 19 studies (in vitro, in situ, and in vivo) were found. Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six studies, where three studies were on remineralization and three on reduction of sensitivity. Overall, the studies analyzed in this
review showed that MIH-affected teeth could be remineralized using calcium phosphate-based approaches. In conclusion, calcium phosphates like CPP-ACP, calcium glycerophosphate, and hydroxyapatite can be used to remineralize MIH-affected teeth. In addition to MIH-remineralization, CPP-ACP and hydroxyapatite also offer relief from MIH-associated tooth sensitivity.