PDF(Pubmed)
Abstract：
UNASSIGNED: Calcium phosphate-based biomaterials (CaP) are the most widely used biomaterials to enhance bone regeneration in the treatment of alveolar bone deficiencies, cranio-maxillofacial and periodontal infrabony defects, with positive preclinical and clinical results reported. This systematic review aimed to assess the influence of the physicochemical properties of CaP biomaterials on the performance of bone regeneration in preclinical animal models.
UNASSIGNED: The PubMed, EMBASE and Web of Science databases were searched to retrieve the preclinical studies investigating physicochemical characteristics of CaP biomaterials. The studies were screened for inclusion based on intervention (physicochemical characterization and in vivo evaluation) and reported measurable outcomes.
UNASSIGNED: A total of 1532 articles were retrieved and 58 studies were ultimately included in the systematic review. A wide range of physicochemical characteristics of CaP biomaterials was found to be assessed in the included studies. Despite a high degree of heterogeneity, the meta-analysis was performed on 39 studies and evidenced significant effects of biomaterial characteristics on their bone regeneration outcomes. The study specifically showed that macropore size, Ca/P ratio, and compressive strength exerted significant influence on the formation of newly regenerated bone. Moreover, factors such as particle size, Ca/P ratio, and surface area were found to impact bone-to-material contact during the regeneration process. In terms of biodegradability, the amount of residual graft was determined by macropore size, particle size, and compressive strength.
UNASSIGNED: The systematic review showed that the physicochemical characteristics of CaP biomaterials are highly determining for scaffold\'s performance, emphasizing its usefulness in designing the next generation of bone scaffolds to target higher rates of regeneration.
UNASSIGNED: The PubMed, EMBASE and Web of Science databases were searched to retrieve the preclinical studies investigating physicochemical characteristics of CaP biomaterials. The studies were screened for inclusion based on intervention (physicochemical characterization and in vivo evaluation) and reported measurable outcomes.
UNASSIGNED: A total of 1532 articles were retrieved and 58 studies were ultimately included in the systematic review. A wide range of physicochemical characteristics of CaP biomaterials was found to be assessed in the included studies. Despite a high degree of heterogeneity, the meta-analysis was performed on 39 studies and evidenced significant effects of biomaterial characteristics on their bone regeneration outcomes. The study specifically showed that macropore size, Ca/P ratio, and compressive strength exerted significant influence on the formation of newly regenerated bone. Moreover, factors such as particle size, Ca/P ratio, and surface area were found to impact bone-to-material contact during the regeneration process. In terms of biodegradability, the amount of residual graft was determined by macropore size, particle size, and compressive strength.
UNASSIGNED: The systematic review showed that the physicochemical characteristics of CaP biomaterials are highly determining for scaffold\'s performance, emphasizing its usefulness in designing the next generation of bone scaffolds to target higher rates of regeneration.
摘要：
■磷酸钙基生物材料（CaP）是最广泛使用的生物材料，可用于治疗牙槽骨缺陷，以增强骨再生，颅颌面和牙周缺陷，临床前和临床结果呈阳性。本系统综述旨在评估CaP生物材料的理化性质对临床前动物模型中骨再生性能的影响。
■PubMed，搜索了EMBASE和WebofScience数据库，以检索研究CaP生物材料理化特性的临床前研究。基于干预(物理化学表征和体内评估)筛选纳入研究并报告可测量的结果。
■共检索到1532篇文章，最终将58项研究纳入系统评价。在所包括的研究中发现了CaP生物材料的广泛的物理化学特性。尽管存在高度异质性，对39项研究进行了荟萃分析,证明了生物材料特性对其骨再生结局的显著影响.这项研究特别表明，大孔径，Ca/P比,抗压强度对新生骨的形成有显著影响。此外，颗粒大小等因素，Ca/P比,在再生过程中，发现表面积会影响骨骼与材料的接触。在生物降解性方面，残余接枝量由大孔尺寸决定，颗粒大小,和抗压强度。
■系统综述表明，CaP生物材料的物理化学特性对支架的性能具有高度的决定作用，强调其在设计下一代骨支架以更高的再生率方面的有用性。
■PubMed，搜索了EMBASE和WebofScience数据库，以检索研究CaP生物材料理化特性的临床前研究。基于干预(物理化学表征和体内评估)筛选纳入研究并报告可测量的结果。
■共检索到1532篇文章，最终将58项研究纳入系统评价。在所包括的研究中发现了CaP生物材料的广泛的物理化学特性。尽管存在高度异质性，对39项研究进行了荟萃分析,证明了生物材料特性对其骨再生结局的显著影响.这项研究特别表明，大孔径，Ca/P比,抗压强度对新生骨的形成有显著影响。此外，颗粒大小等因素，Ca/P比,在再生过程中，发现表面积会影响骨骼与材料的接触。在生物降解性方面，残余接枝量由大孔尺寸决定，颗粒大小,和抗压强度。
■系统综述表明，CaP生物材料的物理化学特性对支架的性能具有高度的决定作用，强调其在设计下一代骨支架以更高的再生率方面的有用性。
