背景:埃希氏菌(E.hermanni)总是伴随着人类的其他细菌感染。在以前的报告中,大多数埃尔曼尼氏大肠杆菌相关感染是由敏感菌株引起的。这里,第一次,我们报告了一例新德里金属β-内酰胺酶(NDM)阳性E.hermannii血流感染的患者。
方法:患者是一名因4天发烧入院的70岁男性,有恶性肿瘤史,肝硬化,和慢性阻塞性肺疾病。入院后,他的血培养结果为E.hermannii阳性.耐药性分析显示NDM耐药呈阳性,对氨曲南敏感,左氧氟沙星,还有阿米卡星.氨曲南治疗8天后血液培养变为阴性。病人的症状有所改善,住院14天后出院。
结论:这是首次报道由NDM阳性E.hermannii菌株引起的血流感染。在这种情况下使用的抗感染方案为临床实践提供了新的参考方案。
BACKGROUND: Escherichia hermannii (E. hermanni) is always accompanied by other bacterial infections in humans. In previous
reports, most E. hermannii-related infections were caused by sensitive strains. Here, for the first time, we report the
case of a patient with New Delhi metallo-β-lactamase (NDM)-positive E. hermannii bloodstream infection.
METHODS: The patient was a 70-year-old male admitted to our hospital due to a 4-day fever, with a history of malignant tumor, liver cirrhosis, and chronic obstructive pulmonary disease. After admission, his blood culture tested positive for E. hermannii. The drug resistance analysis showed positive for NDM resistance, with susceptibility to
aztreonam, levofloxacin, and amikacin. The blood culture turned negative after 8 days of
aztreonam treatment. The patient\'s symptoms improved, and he was discharged after 14 days of hospitalization.
CONCLUSIONS: This is the first report of a bloodstream infection caused by an NDM-positive E. hermannii strain. The anti-infection regimen used in this
case provides a new reference regimen for clinical practice.