Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales.

病例报告 ： 通过弹性体输注器连续输注头孢他啶 - 阿维巴坦和氨曲南的组合 12 周 ， 用于治疗由于产生金属 β - 内酰胺酶的肠杆菌引起的骨和关节感染。

• 影响指数: 5.058
• 发表时间: 2023
• 来源期刊: Front Med (Lausanne)
• DOI: 10.3389/fmed.2023.1224922
• PMID: 37601796
• 文章类型: Case Reports
• 作者列表: Merad Y,Conrad A,Brosset S,Schmidt A,Hanriat C,Lustig S,Laurent F,Kolenda C,Roussel-Gaillard T,Batailler C,Ferry T,

关键词: Enterobacterales; antibiotic resistance; aztreonam; bone and joint infections; ceftazidime-avibactam; elastomeric infusor; metallo-beta-lactamase

Abstract

Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint infections involving metallo-beta-lactamase-producing Enterobacterales, successfully treated at our referral center with aztreonam and ceftazidime-avibactam for 12 weeks in continuous infusions through elastomeric infusors.

摘要

在耐碳青霉烯类肠杆菌中，产生金属-β-内酰胺酶的菌株代表了日益增长的治疗挑战。虽然近年来已经研究了氨曲南和头孢他啶-阿维巴坦用于治疗涉及这些菌株的感染的关联，几乎没有临床数据支持使用这种关联治疗骨和关节感染.我们报告了两例复杂的骨和关节感染，涉及产生金属β-内酰胺酶的肠杆菌，在我们的转诊中心成功使用氨曲南和头孢他啶-阿维巴坦治疗12周,并通过弹性输液连续输注.